Sviluppo di uno scaffold ingegnerizzato iperelastico per la rigenerazione dell’entesi tendinea
Abstract
L’entesi tendine-osso (TTBE) è una struttura composta da tessuto connettivo specializzato, essenziale per garantire una transizione graduale tra tessuto tendineo ed osseo.
Gli infortuni che interessano il TTBE hanno un’elevata incidenza clinica soprattutto negli anziani e nelle popolazioni più attive che praticano sport a vari livelli.
Ogni anno nell’UE e negli USA circa 30 milioni di persone siano sottoposte a procedure di riparazione di tendini/legamenti, con una spesa annua di oltre 150 miliardi di euro. Nonostante le diverse tecniche innovative che sono state sviluppate, la riparazione chirurgica di lesioni da entesi massicce è ancora troppo spesso inadeguata, con un tasso di insuccesso che può arrivare al 79% nei casi più gravi.
Lo scopo di questo progetto è quello di produrre un materiale che possa migliorare gli outcomes della chirurgia riparativa delle TTBE. Per questo, abbiamo realizzato uno scaffold cellularizzato che imita il tessuto di transizione bifasico tendine-fibrocartilagineo del TTBE. Il costrutto è composto da un lato simile a un tendine e un lato simile alla cartilagine, cellularizzato con cellule staminali mesenchimali umane adulte (hMSC). Il nucleo strutturale del nostro costrutto è uno scaffold composto da poly(L-lactide-co-glicolide) di grado medico (PLGA), con elevata porosità interna e proprietà elastiche sufficienti a formare una rete autoportante, e in grado di supportare la proliferazione cellulare.
Impatto:
Con questo progetto abbiamo mirato a sviluppare un costrutto che mima l’entesi tendine-osso per soddisfare il bisogno clinico di costrutti ad alte prestazioni da utilizzare nella chirurgia ricostruttiva dei tendini. Il nostro costrutto ingegnerizzato ha promosso la differenziazione delle cellule staminali verso fenotipi cartilaginei e tendinei. A questo scopo abbiamo utilizzato un bioreattore innovativo che è parte del portfolio di proprietà intellettuale della Fondazione. Inoltre, le proprietà ad alta resistenza dello scaffold PLGA iperelastico conferiscono resistenza meccanica alla nostra struttura. Quindi, il nostro costrutto può supportare la riparazione chirurgica delle lesioni ai tendini, promuovendo una rapida guarigione e migliorando i risultati post-chirurgici.
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ANALYSIS - DISCOVERY
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CLINICAL
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Principal Investigator
Contatto
rgottardi@fondazionerimed.com
Aree terapeutiche:
Prodotto:
Dispositivi biomedicali e Organi artificiali
Collaborazioni:
University of Pennsylvania (UPenn), United States
Bioengineering and Biomaterials Laboratory, Children’s Hospital of Philadelphia (CHOP), United States
Center for Cellular and Molecular Engineering (CCME), University of Pittsburgh, United States
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, United States
Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, United States
The Chinese University of Hong Kong, China
Cell Biology Inspired Tissue Engineering, Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Netherlands
MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Netherlands
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Cranberry extract-based formulations for preventing bacterial biofilms
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Mesenchymal stromal cell secretome in liver failure: Perspectives on COVID-19 infection treatmentWorld J Gastroenterol. 2021 May 7;27(17):1905-1919. doi: 10.3748/wjg.v27.i17.1905.
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Support Vector Machine As A Supervised Learning For The Prioritization Of Novel Potential SARS-CoV-2 Main Protease InhibitorsInternational Journal of Molecular Sciences, 22: 7714, 2021
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Human Amnion-Derived Mesenchymal Stromal Cells in Cirrhotic Patients with Refractory Ascites: A Possible Anti-Inflammatory Therapy for Preventing Spontaneous Bacterial PeritonitisMariangela Pampalone *, Simona Corrao , Giandomenico Amico, PhD , Giampiero Vitale , Rossella Alduino , Pier Giulio Conaldi , Giada Pietrosi
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Application of a Hyperelastic 3D Printed Scaffold for Mesenchymal Stem Cell-Based Fabrication of a Bizonal Tendon Enthesis-like Construct
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Annals of Biomedical Engineering 2021, 49: 3481–3493
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ChemMedChem, 15: 1921–1931, 2020
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BMC Bioinformatics, 21: 310, 2020
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The American Journal of Pathology, 190(1):252-269, 2020
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Front Immunol. 2020 Feb 12:11:54. doi: 10.3389/fimmu.2020.00054. eCollection 2020.
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Biodegradable electrospun fibers enriched with struvite crystal seeds for the recovery of phosphorous and nitrogen
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Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
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Cigarette smoke inhibits the NLRP3 inflammasome and leads to caspase-1 activation via the TLR4-TRIF-caspase-8 axis in human macrophages
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Current Medicinal Chemistry, 27: 1469-1500, 2020
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Cyclodextrins in drug delivery: applications in gene and combination therapy
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Pectin-GPTMS-Based Biomaterial: toward a Sustainable Bioprinting of 3D scaffolds for Tissue Engineering Application
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Biomacromolecules. 2020 Feb 10;21(2):319-327. doi: 10.1021/acs.biomac.9b01332. Epub 2019 Dec 17.
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Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer
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Cancer Immunol Res. 2020 Feb;8(2):167-178. doi: 10.1158/2326-6066.CIR-19-0514. Epub 2019 Dec 12.
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Effects of Mesenchymal Stem Cell Coculture on Human Lung Small Airway Epithelial CellsBiomed Res Int. 2020 Mar 27;2020:9847579. doi: 10.1155/2020/9847579
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Comparative study of the production of soluble factors in human placenta-derived mesenchymal stromal/stem cells grown in adherent conditions or as aggregates in a catheter-like deviceBiochem Biophys Res Commun. 2020 Jan 29;522(1):171-176. doi: 10.1016/j.bbrc.2019.11.069
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An in vitro chondro-osteo-vascular triphasic model of the osteochondral complex
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Biomaterials. 2021 May;272:120773. doi: 10.1016/j.biomaterials.2021.120773. Epub 2021 Mar 22.
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Bioinformatics 21 (Suppl 8), 201 (2020)
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Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signatureDanilo Ciluffo , Viviana Barra , Sergio Spatafora , Claudia Coronnello, PhD , Flavia Contino , Serena Bivona , Salvatore Feo , Aldo Di Leonardo
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Biofabrication, 12 (2): 025013, 2020
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Articolo di rivista
Enhancing Magnetic Resonance Imaging with Computational Fluid DynamicsGiacomo Annio †, Ryo Torii , Ben Ariff , Declan P. O'Regan , Vivek Muthurangu , Andrea Ducci , Victor Tsang , Gaetano Burriesci, PhD *
ASME Journal of Engineering and Science in Medical Diagnostics and Therapy, 2(4): 041010, 2019.
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The Role of Patient-Specific Morphological Features of the Left Atrial Appendage on the Thromboembolic Risk Under Atrial FibrillationGiulio Musotto, PhD †, Alessandra Monteleone, PhD , Danila Vella, PhD , Sofia Di Leonardo, PhD , Alessia Viola, PhD , Giuseppe Pitarresi , Bernardo Zuccarello , Antonio Pantano , Andrew Cook , Giorgia M. Bosi , Gaetano Burriesci, PhD *
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Composite Structures, 225:111178, 2019.
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MTGO-SC, A Tool to Explore Gene Modules in Single-Cell RNA Sequencing DataNelson Nazzicari , Danila Vella, PhD , Claudia Coronnello, PhD , Dario Di Silvestre , Riccardo Bellazzi , Simone Marini
Frontiers in Genetics, 10: 953, 2019.
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Cellular models and assays to study NLRP3 inflammasome biology
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Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke
Ferraro M. , Di Vincenzo S. , , Bucchieri S , Chiara Cipollina, PhD , Gjomarkaj M , Pace E
Experimental Gerontology
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Patent
METHOD FOR FABRICATING A BIOPROSTHETIC HEART VALVE AND BIOPROSTHETIC HEART VALVEGaetano Burriesci, PhD , Benyamin Rahmani , Guerard Byrne , Christopher McGregor
European Patent N. EP3484412B1 - GRANTED
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Establishment and Characterization of 5-Fluorouracil-Resistant Human Colorectal Cancer Stem-Like Cells: Tumor Dynamics under Selection PressureMaria Giovanna Francipane, Ph.D. , Denis Bulanin , Eric Lagasse
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Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer
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Cancers, 11: 1371 (1-16), 2019
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Echocardiography to estimate high filling pressure in patients with heart failure and reduced ejection fraction
Romano G *, Magro S , Agnese V , Mina C , Di Gesaro G , Falletta C , Pasta S , Raffa G , Baravoglia CMH , Novo G , Gandolfo C , Clemenza F , Bellavia D
ESC Heart Fail. 2020 Oct;7(5):2268-2277. doi: 10.1002/ehf2.12748. Epub 2020 Jul 21.
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Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis
Aguilar-Bravo B , Rodrigo-Torres D , Arino S , Coll M , Pose E , Blaya D , Graupera I , Perea L , Vallverdu J , Rubio-Tomas T , Dubuquoy L , Armengol C , Lo Nigro A , Starkel P , Mathurin P , Bataller R , Caballeria J , Jose Lozano J , Gines P , Sancho-Bru P *
Hepatology. 2019 May;69(5):2180-2195. doi: 10.1002/hep.30472. Epub 2019 Mar 12.
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Mesenchymal stromal cells isolated from human fetal liver release soluble factors with a potential role in liver tissue repairDifferentiation. 2019 Jan-Feb;105:14-26. doi: 10.1016/j.diff.2018.12.001
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Genetically engineered probiotic Saccharomyces cerevisiae strains mature human dendritic cells and stimulate Gag-specific memory CD8(+) T cells ex vivo
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Appl Microbiol Biotechnol. 2019 Jul;103(13):5183-5192. doi: 10.1007/s00253-019-09842-8. Epub 2019 Apr 24.
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3D printing for tissue engineering in otolaryngology
Roberto Di Gesù, PhD , Abhinav P. Acharya , Ian Jacobs , Riccardo Gottardi, PhD
Connective tissue research, 61(2): 117-136
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Patterns of ascending aortic dilatation and predictors of surgical replacement of the aorta: A comparison of bicuspid and tricuspid aortic valve patients over eight years of follow-up
Agnese V , Pasta S , Michelena HI , Minà C , Romano GM , Carerj S , Zito C , Maalouf JF , Foley TA , Raffa G , Clemenza F , Pilato M , Bellavia D *
J Mol Cell Cardiol. 2019 Oct;135:31-39. doi: 10.1016/j.yjmcc.2019.07.010. Epub 2019 Jul 23.
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Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments
Iannolo G *, Sciuto MR , Cuscino N , Pallini R , Douradinha B , Ricci Vitiani L , De Maria R , Conaldi PG
Cell Death Dis. 2019 Mar 19;10(4):263. doi: 10.1038/s41419-019-1499-z.
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Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish
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Sci Rep. 2019 Mar 18;9(1):4750. doi: 10.1038/s41598-019-41202-4.
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Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications
Joseph N , Lawson HD , Overholt KJ , Damodaran K , Gottardi R , Acharya AP *, Little SR *
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Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence
De Miranda BR , Fazzari M , Rocha EM , Castro S , Greenamyre JT *
Toxicol Sci. 2019 Jul 1;170(1):133-143. doi: 10.1093/toxsci/kfz082.
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Epidemiology and successful containment of a carbapenem-resistant Enterobacteriaceae outbreak in a Southern Italian Transplant Institute
, Martucci G , Douradinha B , Campanella O , Hazen B , Medaglia A , Arena G , Gruttadauria S , Tuzzolino F , Arcadipane A , Gioè S , Luca A , Conaldi PG , Grossi P , Gridelli B
Transpl Infect Dis. 2019 Aug;21(4):e13119. doi: 10.1111/tid.13119. Epub 2019 Jun 11.
https://onlinelibrary.wiley.com/doi/10.1111/tid.13119Book/Book Chapter
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Lecture Notes in Computer Science, 11751: 399–409, 2019
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Dynamic Compressive Loading Improves Cartilage Repair in an In Vitro Model of Microfracture: Comparison of 2 Mechanical Loading Regimens on Simulated Microfracture Based on Fibin Gel Scaffolds Encapsulating Connective Tissue Progenitor Cells
Iseki T , Rothrauff BB , Kihara S , Sasaki H , Yoshiya S , Fu FH , Tuan RS , Riccardo Gottardi, PhD *
Am J Sports Med. 2019 Jul;47(9):2188-2199. doi: 10.1177/0363546519855645.
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Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids
Fazzari M *, Vitturi DA , Woodcock SR , Salvatore SR , Freeman BA , Schopfer FJ
J Lipid Res. 2019 Feb;60(2):388-399. doi: 10.1194/jlr.M088815. Epub 2018 Dec 13.
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Role of Allelic Imbalance in Predicting Hepatocellular Carcinoma (HCC) Recurrence Risk After Liver Transplant
Pagano D , Barbera F , Conaldi PG , Seidita A , Di Francesco F , Di Carlo D , Barbara M , Tuzzolino F , Luca A , Gruttadauria S *
Ann Transplant. 2019 Apr 24;24:223-233. doi: 10.12659/AOT.913692.
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Journal of Tissue Engineering and Regenerative Medicine, 13(9):1724-1731, 2019
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Wharton's Jelly Mesenchymal Stromal Cells from Human Umbilical Cord: a Close-up on Immunomodulatory Molecules Featured In Situ and In VitroGiandomenico Amico, PhD †, Tiziana Corsello †, Simona Corrao , Rita Anzalone , Francesca Timoneri, PhD , Melania Lo Iacono , Eleonora Russo , Giovanni Francesco Spatola , Maria Laura Uzzo , Mario Giuffrè , Martin Caprnda , Peter Kubatka , Peter Kruzliak , Pier Giulio Conaldi , Giampiero La Rocca *
Stem Cell Rev Rep. 2019 Dec;15(6):900-918. doi: 10.1007/s12015-019-09907-1.
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Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture SystemsVitale Miceli , Mariangela Pampalone , Serena Vella , Anna Paola Carreca , Giandomenico Amico, PhD , Pier Giulio Conaldi
Stem Cells Int. 2019 Feb 18:2019:7486279. doi: 10.1155/2019/7486279. eCollection 2019.
https://www.hindawi.com/journals/sci/2019/7486279/Progetto di ricerca
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Electrospun Scaffolds in Tendons Regeneration: a review
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Quantifying the thermodynamics of protein unfolding using 2D NMR spectroscopyRita Puglisi , Oliver Brylski , Caterina Alfano, PhD , Stephen R. Martin , Annalisa Pastore , Piero A. Temussi
Communications Chemistry, 3:100, 2020
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Blue autofluorescence in protein aggregates "lighted on" by UV induced oxidationAnna Fricano , Fabio Librizzi , Estella Rao , Caterina Alfano, PhD , Valeria Vetri
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1867(11):140258, 2019
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Journal of Biological Chemistry, 294(34):12826-12835, 2019
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RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43Elsa Zacco , Ricardo Graña-Montes , Stephen R. Martin , Natalia Sanchez de Groot , Caterina Alfano, PhD , Gian Gaetano Tartaglia , Annalisa Pastore
Journal of Molecular Biology, 431(8):671-1688, 2019
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Patent
BIOPROSTHETIC HEART VALVEGaetano Burriesci, PhD , Benyamin Rahmani , Guerard Byrne , Christopher Mcgregor
US Patent N. US11109962B2 - GRANTED
Journal Paper
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Medical Engineering & Physics 74:121-128, 2019.
doi: https://doi.org/10.1016/j.medengphy.2019.09.014Progetto di ricerca
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Patient-specific aortic phantom with tunable complianceAntonio Gallarello †, Andrea Palombi , Giacomo Annio , Shervanthi Homer-Vanniasinkam , Elena De Momi , Gabriele Maritati , Ryo Torii , Gaetano Burriesci, PhD , Helge A. Wurdemann *
ASME J of Medical Diagnostics, 2(4): 041005, 2019
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Sizing the aortic annulus with a robotised, commercially available soft balloon catheter: in vitro study on idealised phantomsAndrea Palombi †, Giorgia M Bosi , Sara Di Giuseppe , Elena De Momi , Shervanthi Homer-Vanniasinkam , Gaetano Burriesci, PhD , Helge A Wurdemann *
International Conference on Robotics and Automation (ICRA), 2019, pp. 6230-6236, 2019.
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European Journal of Cardio-Thoracic Surgery, 56(3): 488-494, 2019.
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Journal of Cardiovascular Translational Research, 12(4): 331-337, 2019.
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Efficacy of thermoresponsive, photocrosslinkable hydrogels derived from decellularized tendon and cartilage extracellular matrix for cartilage tissue engineering
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J Tissue Eng Regen Med. 2018 Jan;12(1):e159-e170. doi: 10.1002/term.2465. Epub 2017 Aug 21.
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A New Family Of Jumonji C Domain-Containing KDM Inhibitors Inspired By Natural Product PurpurogallinJose A Souto , Federica Sarno , Angela Nebbioso , Chiara Papulino , Rosana Álvarez , Lucia Altucci , Jessica Lombino , Ugo Perricone, PhD , Alessandro Padova , Ángel R. De Lera
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In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06
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Modeling Right Ventricle Failure After Continuous Flow Left Ventricular Assist Device: A Biventricular Finite-Element and Lumped-Parameter Analysis
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Infant colonisation with Escherichia coli and Klebsiella pneumoniae strains co-harbouring bla(OXA-48) and bla(NDM-1) carbapenemases genes: a case report
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Int J Antimicrob Agents. 2018 Jul;52(1):121-122. doi: 10.1016/j.ijantimicag.2018.04.018. Epub 2018 May 9.
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J Allergy Clin Immunol. 2018 Jul;142(1):109-119.e6. doi: 10.1016/j.jaci.2017.10.029. Epub 2017 Nov 15.
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The Use Of Dynamic Pharmacophore In Computer-Aided Hit Discovery: A Case StudyUgo Perricone, PhD †, Marcus Wieder , Thomas Seidel , Thierry Langer , Alessandro Padova
Rational Drug Design - Methods in Molecular Biology, 1824: 317–333, 2018
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Nitro-fatty acid formation and metabolism
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Porous Poly(vinyl alcohol)-Based Hydrogel for Knee Meniscus Functional Repair
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ACS Biomater Sci Eng. 2018 May 14;4(5):1518-1527. doi: 10.1021/acsbiomaterials.7b00879. Epub 2018 Mar 22.
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An Overview Of Recent Molecular Dynamics Applications As Medicinal Chemistry Tools For The Undruggable Site ChallengeUgo Perricone, PhD ‡, Maria Rita Gulotta, PhD ‡, Jessica Lombino , Barbara Parrino , Stella Cascioferro , Patrizia Diana , , Girolamo Cirrincione , Alessandro Padova
MedChemComm, 9: 920-936, 2018
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MiR34 inhibition induces human heart progenitor proliferation
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Cell Death Dis. 2018 Mar 6;9(3):368. doi: 10.1038/s41419-018-0400-9.
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Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease
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Antioxid Redox Signal. 2018 Jan 1;28(1):44-61. doi: 10.1089/ars.2017.6992. Epub 2017 Sep 21.
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Biomechanical Determinants of Right Ventricular Failure in Pulmonary Hypertension
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ASAIO J. 2018 Jul/Aug;64(4):557-564. doi: 10.1097/MAT.0000000000000683.
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Peripheral Artery Disease and Continuous Flow Left Ventricle Assist Device: An Engaging Complement Analysis May Help to Guide Treatment
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Artif Organs. 2018 Jul;42(7):756-759. doi: 10.1111/aor.13105. Epub 2018 Feb 13.
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Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence
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CNS Neurosci Ther. 2018 Aug;24(8):721-733. doi: 10.1111/cns.12830. Epub 2018 Feb 25.
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LRRK2 activation in idiopathic Parkinson's disease
Di Maio R , Hoffman EK , Rocha EM , Keeney MT , Sanders LH , De Miranda BR , Zharikov A , Van Laar A , Stepan AF , Lanz TA , Kofler JK , Burton EA , Alessi DR , Hastings TG , Greenamyre JT *
Sci Transl Med. 2018 Jul 25;10(451):eaar5429. doi: 10.1126/scitranslmed.aar5429.
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Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice
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Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E180-E195. doi: 10.1152/ajpendo.00311.2017. Epub 2018 Feb 27.
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Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice
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JCI Insight. 2018 Mar 8;3(5):e97735. doi: 10.1172/jci.insight.97735.
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Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology
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Stem Cell Res Ther. 2018 Apr 20;9(1):112. doi: 10.1186/s13287-018-0847-8.
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Regenerative Rehabilitation of the Musculoskeletal System
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Book/Book Chapter
Advances in multidrug delivery from electrospun nanomaterials in Core-Shell Nanostructures for Drug Delivery and Theranostics
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Core-Shell Nanostructures for Drug Delivery and Theranostics, 14:405-430, 2018
https://doi.org/10.1016/B978-0-08-102198-9.00014-4Patent
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International Publication N. WO2018011592
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Validation and Extension of a Fluid–Structure Interaction Model of the Healthy Aortic ValveAnna Maria Tango †, Jacob Salmonsmith , Andrea Ducci , Gaetano Burriesci, PhD *
Cardiovascular Engineering and Technology 9(4): 739-751, 2018.
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Statistical shape analysis of the right ventricular outflow tract in patients with tetralogy of FallotStephane Couvreur , Agnieszka Nowacka , Benedetta Biffi , Jan Bruse , Gaetano Burriesci, PhD , Andrew Taylor , Claudio Capelli , Silvia Schievano *
Journal of Vascular and Endovascular Therapy, 3: 106, 2018.
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Computational Fluid Dynamic Analysis of the Left Atrial Appendage to Predict Thrombosis RiskGiorgia Maria Bosi †, Andrew Cook , Rajan Rai , Leon J. Menezes , Silvia Schievano , Ryo Torii , Gaetano Burriesci, PhD *
Journal of Vascular and Endovascular Therapy, 3: 106, 2018.
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A multi-domain approach for smoothed particle hydrodynamics simulations of highly complex flowsAlessandra Monteleone, PhD †, Mauro De Marchis , Barbara Milici , Enrico Napoli *
Computer Methods in Applied Mechanics and Engineering, 340: 956–977, 2018.
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Numerical Simulations of the Hydrodynamics of the Abdominal Aorta Aneurysm (AAA) Using a Smoothed Particle Hydrodynamics Code with Deformable Wall Preliminary ResultsCostanza Aricò , Gioacchino Alotta , Massimiliano Zingales , Enrico Napoli , Alessandra Monteleone, PhD , Robert Nagy
IEEE 4th International Forum on Research and Technologies for Society and Industry, RTSI 2018 - Proceedings, 8548389, 2018.
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Influence of systemic infection and comorbidities on rehabilitation outcomes in severe acquired brain injuryGianluca Bellaviti , Francesca Balsamo , Marco Iosa , Danila Vella, PhD , Caterina Pistarini
European Journal of Physical and Rehabilitation Medicine, 57(1): 69-77, 2021.
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MTGO: PPI Network Analysis Via Topological and Functional Module IdentificationDanila Vella, PhD †, Simone Marini , Francesca Vitali , Dario Di Silvestre , Giancarlo Mauri , Riccardo Bellazzi
Scientific Reports, 8: 5499, 2018.
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Electrophilic derivatives of omega-3 fatty acids counteract lung cancer cell growth
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SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells
Di Vincenzo, Serena , Heijink, Irene H , Noordhoek, Jacobien A , Chiara Cipollina, PhD , Siena, Liboria , Bruno, Andreina , Ferraro, Maria , Postma, Dirkje S , Gjomarkaj, Mark , Pace, Elisabetta
Journal of Cellular and Molecular Medicine
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Thrombopoietin mutation in congenital amegakaryocytic thrombocytopenia treatable with romiplostimAlessandro Pecci , Iman Ragab , Valeria Bozzi , Daniela De Rocco , Serena Barozzi , Tania Giangregorio , Heba Ali , Federica Melazzini , Mohamed Sallam , Caterina Alfano, PhD , Annalisa Pastore , Carlo Luigi Balduini , Anna Savoia
EMBO Molecular Medicine, 10(1):63-75, 2018
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Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human FibroblastsDanilo Cilluffo , Roberta Flavia Chiavetta , Serena Bivona , Flavia Contino , Claudia Coronnello, PhD , Salvatore Feo , Aldo Di Leonardo , Viviana Barra
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Nitrite Improves Heart Regeneration in Zebrafish
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Unbiased and quantitative proteomics reveals highly increased angiogenesis induction by the secretome of mesenchymal stromal cells isolated from fetal rather than adult skinTissue Eng Regen Med. 2018 Feb;12(2):e949-e961. doi: 10.1002/term.2417
https://pubmed.ncbi.nlm.nih.gov/28102936/Progetto di ricerca
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On the prospect of serum exosomal miRNA profiling and protein biomarkers for the diagnosis of ascending aortic dilatation in patients with bicuspid and tricuspid aortic valve
Alessia Gallo , Valentina Agnese , Claudia Coronnello, PhD , Giuseppe M. Raffa , Diego Bellavia , Pier Giulio Conaldi , Michele Pilato , Salvatore Pasta
International Journal of Cardiology, 273:230-236, 2018
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Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells
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Journal of nanobiotechnology, 16 (3), 2014
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Design, Analysis and Testing of a Novel Mitral Valve for Transcatheter ImplantationAnnals of Biomedical Engineering, 45(8): 1852-1864, 2017.
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In-Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (The TRISKELE)Benyamin Rahmani †, Spyros Tzamtzis , Rose Sheridan , Michael J Mullen , John Yap , Alexander M. Seifalian , Gaetano Burriesci, PhD *
Cardiovascular Translational Research, 10(2):104-115, 2017.
https://doi.org/10.1007/s12265-016-9722-0Progetto di ricerca
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Patent
CARDIAC VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini
US Patent N. US9895223B2 - GRANTED
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Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
Maria De Rosa, PhD , Lu Lu , Edouard Zamaratski , Natalia Szałaj , Sha Cao , Henrik Wadensten , Lena Lenhammar , Johan Gising , Annette K. Roos , Douglas L. Huseby , Rolf Larsson , Per E. Andrén , Diarmaid Hughes , Peter Brandt , Sherry L. Mowbray , Anders Karlén
Bioorganic & Medicinal Chemistry, 25: 897–911, 2017
http://dx.doi.org/10.1016/j.bmc.2016.12.003Journal Paper
Synthesis and in vitro evaluation of 5-substituted benzovesamicol analogs containing N-substituted amides as potential positron emission tomography tracers for the vesicular acetylcholine transporter
Sara Roslin , Maria De Rosa, PhD , Winnie Deuther-Conrad , Jonas Eriksson , Luke R. Odell , Gunnar Antoni , Peter Brust , Mats Larhed
Bioorganic & Medicinal Chemistry, 25: 5095–5106, 2017
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In vitro evidences of epithelial to mesenchymal transition in low cell-density cultured human fetal hepatocytesBiochem Biophys Res Commun. 2017 Aug 19;490(2):472-479. doi: 10.1016/j.bbrc.2017.06.065
https://pubmed.ncbi.nlm.nih.gov/28624456/Progetto di ricerca
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Report on Liver Cell Transplantation Using Human Fetal Liver CellsMethods Mol Biol. 2017;1506:283-294. doi: 10.1007/978-1-4939-6506-9_20
https://pubmed.ncbi.nlm.nih.gov/27830561/Journal Paper
2-Methoxyestradiol Impacts On Amino Acids-Mediated Metabolic Reprogramming In Osteosarcoma Cells By Its Interaction With NMDA ReceptorMagdalena Gorska-Ponikowska †, Ugo Perricone, PhD , Alicja Kuban-Jankowska , Giosuè Lo Bosco , Giampaolo Barone *
Journal of Cellular Physiology, 232(11): 3030-3049, 2017
https://doi.org/10.1002/jcp.25888Progetto di ricerca
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A Molecular Dynamics–Shared Pharmacophore Approach To Boost Early-Enrichment Virtual Screening: A Case Study On Peroxisome Proliferator-Activated Receptor ΑUgo Perricone, PhD †, Marcus Wieder , Thomas Seidel , Thierry Langer , Alessandro Padova , Anna Maria Almerico , Marco Tutone *
ChemMedChem, 12: 1399-1407, 2017
https://doi.org/10.1002/cmdc.201600526Progetto di ricerca
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Journal Paper
Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation
Ratay ML , Bellotti E , Riccardo Gottardi, PhD , Little SR *
Adv Healthc Mater. 2017 Dec;6(23):10.1002/adhm.201700733. doi: 10.1002/adhm.201700733. Epub 2017 Oct 16.
https://onlinelibrary.wiley.com/doi/10.1002/adhm.201700733Journal Paper
In Vivo Strain Analysis of Dilated Ascending Thoracic Aorta by ECG-Gated CT Angiographic Imaging
Pasta S *, Agnese V , Marzio Di Giuseppe, PhD , Gentile G , Raffa GM , Bellavia D , Pilato M
Ann Biomed Eng. 2017 Dec;45(12):2911-2920. doi: 10.1007/s10439-017-1915-4. Epub 2017 Sep 7.
https://link.springer.com/article/10.1007/s10439-017-1915-4Progetto di ricerca
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Shear stress alterations in the celiac trunk of patients with a continuous-flow left ventricular assist device as shown by in-silico and in-vitro flow analyses
Scardulla F , Pasta S *, D'Acquisto L , Sciacca S , Agnese V , Vergara C , Quarteroni A , Clemenza F , Bellavia D , Pilato M
J Heart Lung Transplant. 2017 Aug;36(8):906-913. doi: 10.1016/j.healun.2017.03.016. Epub 2017 Mar 24.
https://www.jhltonline.org/article/S1053-2498(17)31731-X/fulltextProgetto di ricerca
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Special Issue on "Frontier Biomechanical Challenges in Cardiovascular Physiopathology"
Pasta S *, Zingales M
Med Eng Phys. 2017 Sep;47:1. doi: 10.1016/j.medengphy.2017.08.001.
https://www.sciencedirect.com/science/article/abs/pii/S1350453317302102?via%3DihubProgetto di ricerca
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Isolation and characterization of Sprague-Dawley and Wistar Kyoto GFP rat embryonic stem cells
Coppiello G , Abizanda G , Aguado N , Iglesias E , Iglesias-Garcia O , Lo Nigro A , Prosper F *, Aranguren XL *
Stem Cell Res. 2017 May;21:40-43. doi: 10.1016/j.scr.2017.03.020. Epub 2017 Mar 29.
https://www.sciencedirect.com/science/article/pii/S1873506117300648?via%3DihubProgetto di ricerca
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Generation of a Sprague-Dawley-GFP rat iPS cell line
Coppiello G , Abizanda G , Aguado N , Iglesias E , Iglesias-Garcia O , Lo Nigro A , Prosper F , Aranguren XL
Stem Cell Res. 2017 May;21:47-50. doi: 10.1016/j.scr.2017.03.021. Epub 2017 Mar 31.
https://www.sciencedirect.com/science/article/pii/S187350611730065X?via%3DihubProgetto di ricerca
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PDGFRα(+) Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors
Lo Nigro A *, de Jaime-Soguero A , Khoueiry R , Cho DS , Ferlazzo GM , Perini I , Abon Escalona V , Aranguren XL , Chuva de Sousa Lopes SM , Koh KP , Conaldi PG , Hu WS , Zwijsen A , Lluis F , Verfaillie CM
Stem Cell Reports. 2017 Feb 14;8(2):318-333. doi: 10.1016/j.stemcr.2016.12.010. Epub 2017 Jan 12.
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(16)30300-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671116303009%3Fshowall%3DtrueProgetto di ricerca
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Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets
Garcia-Contreras M *, Tamayo-Garcia A , Pappan KL , Michelotti GA , Stabler CL , Ricordi C , Buchwald P
J Proteome Res. 2017 Jun 2;16(6):2294-2306. doi: 10.1021/acs.jproteome.7b00160. Epub 2017 May 9.
https://pubs.acs.org/doi/10.1021/acs.jproteome.7b00160Progetto di ricerca
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Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes
Garcia-Contreras M , Shah SH , Tamayo A , Robbins PD , Golberg RB , Mendez AJ *, Ricordi C *
Sci Rep. 2017 Jul 20;7(1):5998. doi: 10.1038/s41598-017-05787-y.
https://www.nature.com/articles/s41598-017-05787-yProgetto di ricerca
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Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans
Salvatore SR , Vitturi DA , Fazzari M , Jorkasky DK , Schopfer FJ *
Sci Rep. 2017 Jan 5;7:39900. doi: 10.1038/srep39900.
https://www.nature.com/articles/srep39900Progetto di ricerca
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Rapidly dissociated autologous meniscus tissue enhances meniscus healing: An in vitro study
Numpaisal PO , Rothrauff BR , Riccardo Gottardi, PhD , Chien CL , Tuan RS *
Connect Tissue Res. 2017 May-Jul;58(3-4):355-365. doi: 10.1080/03008207.2016.1245727. Epub 2016 Oct 11.
https://www.tandfonline.com/doi/full/10.1080/03008207.2016.1245727Journal Paper
Controlled and sustained release of a corticosteroid drug from block copolymers synthetized by ATRP
Graziella Valenti , Stefania La Carta , Giovanni Mazzotti , Marco Rapisarda , Stefania Perna , Roberto Di Gesù, PhD , Loris Giorgini , Domenico Carmelo Carbone , Giuseppe Recca , Paola Rizzarelli
Polymer Engineering and Science, 57(6):570-579, 2017
https://doi.org/10.1002/pen.24557Book/Book Chapter
A Mesoscale 3D Culture System for Native and Engineered Biphasic Tissues: Application to the Osteochondral Unit
Irene Chiesa , Roberto Di Gesù, PhD , Kalon J. Overholt , Riccardo Gottardi, PhD
Organ-on-a-Chip - Method in molecular biology, 2373: 267-281
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Programmed Platelet-Derived Growth Factor-BB and Bone Morphogenetic Protein-2 Delivery from a Hybrid Calcium Phosphate/Alginate Scaffold
Bayer EA , Jordan J , Roy A , Riccardo Gottardi, PhD , Fedorchak MV , Kumta PN , Little SR *
Tissue Eng Part A. 2017 Dec;23(23-24):1382-1393. doi: 10.1089/ten.TEA.2017.0027. Epub 2017 Jun 27.
https://www.liebertpub.com/doi/10.1089/ten.TEA.2017.0027?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmedJournal Paper
Computational fluid dynamics of the ascending aorta before the onset of type A aortic dissection
Malvindi PG , Pasta S , Raffa GM , Livesey S *
Eur J Cardiothorac Surg. 2017 Mar 1;51(3):597-599. doi: 10.1093/ejcts/ezw306.
https://academic.oup.com/ejcts/article/51/3/597/2669447?login=falseJournal Paper
Gray platelet syndrome: Novel mutations of the NBEAL2 geneRoberta Bottega , Elena Nicchia , Caterina Alfano, PhD , Ana C. Glembotsky , Annalisa Pastore , Debora Bertaggia-Calderara , Bettina Bisig , Michel André Duchosal , Guillermo Arbesú , Lorenzo Alberio , Paula Graciela Heller , Anna Savoia
American Journal of Hematology, 92(2):E20-E22, 2017
https://doi.org/10.1002/ajh.24610Progetto di ricerca
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Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfBSantiago Martínez-Lumbreras ‡, Caterina Alfano, PhD ‡, Nicola J. Evans , Katherine M. Collins , Kelly A. Flanagan , R. Andrew Atkinson , Ewelina Maria Krysztofinska , Anupama Vydyanath , Jacquelin Jackter , Sarah Fixon-Owoo , Amy H. Camp , Rivka L. Isaacson
Structure, 26(4):640-648, 2018
https://doi.org/10.1016/j.str.2018.02.007Progetto di ricerca
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The Expression and Purification of ZASP Subdomains and Clinically Important Isoforms: High-affinity Binding to G-actinNorman R. Watts , Xiaolei Zhuang , Joshua D. Kaufman , Ira W. Palmer , Altaira D. Dearborn , Stephen Coscia , Yotam Blech-Hermoni , Caterina Alfano, PhD , Annalisa Pastore , Ami Mankodi , Paul T. Wingfield
Biochemistry, 56(14):2061-2070, 2017
https://doi.org/10.1021/acs.biochem.7b00067Progetto di ricerca
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An optimized strategy to measure protein stability highlights differences between cold and hot unfolded statesCaterina Alfano, PhD , Domenico Sanfelice , Stephen R. Martin , Annalisa Pastore , Piero Andrea Temussi
Nature Communications, 8:15428, 2017
https://doi.org/10.1038/ncomms15428Progetto di ricerca
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Global profiling of viral and cellular non-coding RNAs in Epstein-Barr virus-induced lymphoblastoid cell lines and released exosome cargos
Alessia Gallo , Serena Vella , Francesca Timoneri, PhD , Monica Miele , Mariangela Di Bella , Silvia Bosi , Marco Sciveres , Pier Giulio Conaldi
https://www.sciencedirect.com/science/article/pii/S0304383516307480?via%3DihubProgetto di ricerca
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Low cost fabrication of PVA based personalized vascular phantoms for in vitro haemodynamic studies: three applicationsGiacomo Annio †, Gaia Franzetti , Mirko Bonfanti , Antonio Gallarello , Andrea Palombi , Elena De Momi , Shervanthi Homer-Vanniasinkam , Helge A. Wurdemann , Victor Tsang , Vanessa Diáz-Zuccarini , Ryo Torii , Stavroula Balabani , Gaetano Burriesci, PhD *
ASME Journal of Engineering and Science in Medical Diagnostics and Therapy 2020, 3(3): 034501
https://doi.org/10.1115/1.4045760Progetto di ricerca
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In-vitro assessment of pacing as therapy for aortic regurgitationOpen Heart, 6: e000976, 2019.
http://dx.doi.org/10.1136/openhrt-2018-000976Progetto di ricerca
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Towards Organs On Demand: Breakthroughs And Challenges In Models Of OrganogenesisMaria Giovanna Francipane, Ph.D. , Eric Lagasse
Current Pathobiology Reports, 4(3): 77–85, 2016
https://doi.org/10.1007/s40139-016-0111-9Progetto di ricerca
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Pluripotent Stem Cells To Rebuild A Kidney: The Lymph Node As A Possible Developmental NicheMaria Giovanna Francipane, Ph.D. , Eric Lagasse
Cell Transplantation, 25(6):1007-23, 2016
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Anatomical region-dependent enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix
Rothrauff BB , Shimomura K , Riccardo Gottardi, PhD , Alexander PG , Tuan RS *
Acta Biomater. 2017 Feb;49:140-151. doi: 10.1016/j.actbio.2016.11.046. Epub 2016 Nov 19.
https://www.sciencedirect.com/science/article/abs/pii/S1742706116306420?via%3DihubJournal Paper
Particle image velocimetry study of the celiac trunk hemodynamic induced by continuous-flow left ventricular assist device
Scardulla F *, Bellavia D , D'Acquisto L , Raffa GM , Pasta S
Med Eng Phys. 2017 Sep;47:47-54. doi: 10.1016/j.medengphy.2017.06.029. Epub 2017 Jul 12.
https://www.sciencedirect.com/science/article/abs/pii/S1350453317301686?via%3DihubProgetto di ricerca
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Clinical and pathogenetic features of ETV6 related thrombocytopenia with predisposition to acute lymphoblastic leukemiaFederica Melazzini , Flavia Palombo , Alessandra Balduini , Daniela De Rocco , Caterina Marconi , Patrizia Noris , Chiara Gnan , Tommaso Pippucci , Valeria Bozzi , Michela Faleschini , Serena Barozzi , Michael Doubek , Christian Andrea Di Buduo , Katerina Stano Kozubik , Lenka Radova , Giuseppe Loffredo , Sarka Pospisilova , Caterina Alfano, PhD , Marco Seri , Carlo Luigi Balduini , Alessandro Pecci , Anna Savoia
Haematologica, 101(11):1333-1342, 2016
https://doi.org/10.3324/haematol.2016.147496Progetto di ricerca
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Journal Paper
A Novel RNA Polymerase-binding Protein that interacts with a Sigma-Factor Docking SiteAnna F. Wang Erickson , Padraig Deighan , Shanshan Chen , Kelsey Barrasso , Cinthia P. Garcia , Santiago Martínez-Lumbreras , Caterina Alfano, PhD , Ewelina Maria Krysztofinska , Arjun Thapaliya , Amy H. Camp , Rivka L. Isaacson , Ann Hochschild , Richard Losick
Molecular Microbiology, 105(4):652-662, 2017
https://doi.org/10.1111/mmi.13724Progetto di ricerca
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Journal Paper
The ball and chain of polyubiquitin structural studiesCaterina Alfano, PhD , Serena Faggiano , Annalisa Pastore
Trends in Biochemical Sciences, 41(4):371-385, 2016
https://doi.org/10.1016/j.tibs.2016.01.006Progetto di ricerca
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Journal Paper
The missing links to link ubiquitin: Methods for the enzymatic production of polyubiquitin chainsSerena Faggiano , Caterina Alfano, PhD , Annalisa Pastore
Analytical Biochemistry, 492:82-90, 2016
https://doi.org/10.1016/j.ab.2015.09.013Progetto di ricerca
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Patent
PROSTHETIC HEART VALVEGaetano Burriesci, PhD , Selim Bozkurt , Benyamin Rahmani , Michael J Mullen
GB Patent Publication N. GB2539444
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Patent
PROSTHETIC HEART VALVEGaetano Burriesci, PhD , Selim Bozkurt , Benyamin Rahmani , Michael J. Mullen
International Patent Application N. WO2016203241
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Journal Paper
Does Transcatheter Aortic Valve Alignment Matter?Jacob Andrew Salmonsmith †, Andrea Ducci , Gaetano Burriesci, PhD *
Open Heart, 6: e001132, 2019
http://dx.doi.org/10.1136/openhrt-2019-001132Progetto di ricerca
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3D printing assisted finite element analysis for optimising the manufacturing parameters of a lumbar fusion cageMaterials and Design, 163: 107540, 2019.
https://doi.org/10.1016/j.matdes.2018.107540Progetto di ricerca
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Anatomically realistic ultrasound phantoms using gel wax with 3D printed mouldsEfthymios Maneas , Wenfeng Xia , Daniil I Nikitichev , Batol Daher , Maniragav Manimaran , Rui Yen J Wong , Chia-Wei Chang , Benyamin Rahmani , Claudio Capelli , Silvia Schievano , Gaetano Burriesci, PhD , Sebastien Ourselin , Anna L David , Malcolm C Finlay , Simeon J West , Tom Vercauteren , Adrien E Desjardins
Physics in Medicine and Biology, 63(1): 015033, 2018.
https://iopscience.iop.org/article/10.1088/1361-6560/aa9e2cProgetto di ricerca
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Articolo di rivista
Transcatheter aortic valves produce unphysiological flows which may contribute to thromboembolic events: an in-vitro studyAndrea Ducci †, Francesco Pirisi , Spyridon Tzamtzis , Gaetano Burriesci, PhD *
Journal of Biomechanics 49(16): 4080-4089, 2016.
https://doi.org/10.1016/j.jbiomech.2016.10.050Progetto di ricerca
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Articolo di rivista
A new transcatheter heart valve concept (the TRISKELE): feasibility in an acute preclinical modelBenyamin Rahmani †, Spyros Tzamtzis , Rose Sheridan , Michael J. Mullen , John Yap , Alexander M. Seifalian , Gaetano Burriesci, PhD *
EuroIntervention, 12(7):901-908, 2016.
https://doi.org/10.4244/eijv12i7a148Progetto di ricerca
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Can finite element models of ballooning procedures yield mechanical response of the cardiovascular site to overexpansion?Giorgia M. Bosi †, Benedetta Biffi †, Giovanni Biglino , Valentina Lintas , Rod Jones , Spyros Tzamtzis , Gaetano Burriesci, PhD , Francesco Migliavacca , Sachin Khambadkone , Andrew M. Taylor , Silvia Schievano
Journal of Biomechanics, 49(13): 2778–2784, 2016.
https://doi.org/10.1016/j.jbiomech.2016.06.021Progetto di ricerca
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Physiological vortices in the sinuses of Valsalva: An in vitro approach for bio-prosthetic valvesRiccardo Toninato †, Jacob Salmon †, Francesca Maria Susin , Andrea Ducci , Gaetano Burriesci, PhD *
Journal of Biomechanics, 49(13): 2635-2643, 2016.
https://doi.org/10.1016/j.jbiomech.2016.05.027Progetto di ricerca
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Impact of different aortic valve calcification patterns on the outcome of transcatheter aortic valve implantation: A finite element studyFrancesco Sturla ‡, Mattia Ronzoni , Mattia Vitali , Annalisa Dimasi , Riccardo Vismara , Georgia Preston-Maher , Gaetano Burriesci, PhD , Emiliano Votta , Alberto Redaelli
Journal of Biomechanics 49(12): 2520–2530, 2016.
https://doi.org/10.1016/j.jbiomech.2016.03.036Progetto di ricerca
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Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic ValvesAndrea Colli , Andrea Ducci , Gaetano Burriesci, PhD
New England Journal of Medicine 374(16): 1590-1592, 2016.
https://doi.org/10.1056/nejmc1600179Progetto di ricerca
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Numerical model of a valvuloplasty balloon: in vitro validation in a rapid-prototyped phantomBenedetta Biffi , Giorgia M. Bosi , Valentina Lintas , Rod Jones , Spyros Tzamtzis , Gaetano Burriesci, PhD , Francesco Migliavacca , Andrew M. Taylor , Silvia Schievano , Giovanni Biglino
BioMedical Engineering OnLine, 15: 37, 2016
https://doi.org/10.1186/s12938-016-0155-4Progetto di ricerca
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Novel heart valve prosthesis with self-endothelialization potential made of modified polyhedral oligomeric silsesquioxane-nanocomposite materialHossein Ghanbari , Dina Radenkovic , Sayed Mahdi Marashi , Shirin Parsno , Nima Roohpour , Gaetano Burriesci, PhD , Alexander M. Seifalian
Biointerphases 11, 029801, 2016.
https://doi.org/10.1116/1.4939036Progetto di ricerca
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In vitro hemodynamic testing of Amplatzer plugs for paravalvular leak occlusion after transcatheter aortic valve implantationInternational Journal of Cardiology, 203:1093-1099, 2016.
https://doi.org/10.1016/j.ijcard.2015.11.106Progetto di ricerca
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Journal Paper
Haemodynamic Issues with Transcatheter Aortic Valve ImplantationJacob Salmonsmith , Anna Maria Tango , Andrea Ducci , Gaetano Burriesci, PhD
In: Giordano A., Biondi-Zoccai G., Frati G. (eds) Transcatheter Aortic Valve Implantation. Springer, Cham, pp 47-59, 2019.
https://doi.org/10.1007/978-3-030-05912-5_5Progetto di ricerca
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Journal Paper
A coupled Finite Volume–Smoothed Particle Hydrodynamics method for incompressible flowsEnrico Napoli , Mauro De Marchis , Chiara Gianguzzi , Barbara Milici , Alessandra Monteleone, PhD
Computer Methods in Applied Mechanics and Engineering, 310: 674-693, 2016.
https://doi.org/10.1016/j.cma.2016.07.034Progetto di ricerca
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Journal Paper
In vitro and ex-vivo Hemodynamic Testing of an Innovative Occluder for Paravalvular Leak after Transcather Aortic Valve ImplantationJournal of Cardiovascular Translational Research, 12(6):551-559, 2019.
https://doi.org/10.1007/s12265-019-09902-4Journal Paper
Ceftaroline modulates the innate immune and host defense responses of immunocompetent cells exposed to cigarette smoke
Bruno A. , Chiara Cipollina, PhD , Di Vincenzo S. , Siena L. , , Di Gaudio F , Gjomarkaj M , Pace E
Toxicology Letters
https://doi.org/10.1016/j.toxlet.2017.07.878Progetto di ricerca
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Journal Paper
17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the NLRP3 inflammasome
Chiara Cipollina, PhD , Di Vincenzo, Serena , Siena, Liboria , Di Sano, Caterina , Gjomarkaj, Mark , Pace, Elisabetta
Scientific Reports
https://doi.org/10.1038/srep37625Progetto di ricerca
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Patent
VASCULAR IMPLANTGaetano Burriesci, PhD , Spyridon Tzamtzis , Michael John Mullen , Alexander Seifalian , John Yap
European Patent N. EP3043746B1
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Journal Paper
PROSTHETIC HEART VALVEGaetano Burriesci, PhD , Selim Bozkurt , Benyamin Rahmani , Michael J. Mullen
US Patent N. US10980632B2 (GRANTED)
Journal Paper
Therapeutic Potential of mTOR Inhibitors for Targeting Cancer Stem CellsMaria Giovanna Francipane, Ph.D. , Eric Lagasse
British Journal of Clinical Pharmacology, 82(5): 1180–1188, 2016
https://doi.org/10.1111/bcp.12844Progetto di ricerca
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Journal Paper
Gene-based and semantic structure of the Gene Ontology as a complex networkClaudia Coronnello, PhD , Michele Tumminello , Salvatore Micciché
Physica A: Statistical Mechanics and its Applications 458: 313-328, 2016
https://doi.org/10.1016/j.physa.2016.03.062Libro
Heart Valves, Polymeric: BiocompatibilityBenyamin Rahmani , Brian G. Cousins , Gaetano Burriesci, PhD , Alexander M. Seifalian
Encyclopedia of Biomedical Polymers and Polymeric Biomaterials (8330 pages), ed. M Mishra, CRC Press, 2015.
https://doi.org/10.1081/E-EBPPCProgetto di ricerca
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From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic dataDanila Vella, PhD , Italo Zoppis , Giancarlo Mauri , Pierluigi Mauri , Dario Di Silvestre
Eurasip Journal on Bioinformatics and Systems Biology, 2017(1): 6, 2017.
https://dx.doi.org/10.1186/s13637-017-0059-zProgetto di ricerca
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Book/Book Chapter
Electrophilic Derivatives of Omega-3 Fatty Acids for the Cure and Prevention of Neurodegenerative Disorders
Chiara Cipollina, PhD , Schopfer, Francisco J. ,
Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy
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Journal Paper
Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives
BioMed Research International
https://doi.org/10.1155/2015/501792Progetto di ricerca
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Patent
CARDIAC VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini
US Patent N. US9486313B2 - GRANTED
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Journal Paper
Aspartic protease inhibitors containing tertiary alcohol transition-state mimics
Hitesh V. Motwani , Maria De Rosa, PhD , Luke R. Odell , Anders Hallberg , Mats Larhed
European Journal of Medicinal Chemistry, 90: 462-490, 2015
http://dx.doi.org/10.1016/j.ejmech.2014.11.036Progetto di ricerca
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Phases I-II Matched Case-Control Study of Human Fetal Liver Cell Transplantation for Treatment of Chronic Liver DiseaseCell Transplant. 2015;24(8):1627-38. doi: 10.3727/096368914X682422
https://pubmed.ncbi.nlm.nih.gov/24971879/Journal Paper
Characterization of Liver-Specific Functions of Human Fetal Hepatocytes in CultureCell Transplant. 2015;24(6):1139-53. doi: 10.3727/096368914X680082
https://pubmed.ncbi.nlm.nih.gov/24667036/Journal Paper
Isolation and characterization of multipotent cells from human fetal dermisCell Transplant. 2014;23(10):1169-85. doi: 10.3727/096368913X668618.
https://pubmed.ncbi.nlm.nih.gov/23768775/Progetto di ricerca
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Phenotypical characterization of 6-21-week gestational age human dermis and epidermal cell isolation methods for in vitro studies on epidermal progenitorsBurns. 2013 Mar;39(2):300-10. doi: 10.1016/j.burns.2012.05.025
https://pubmed.ncbi.nlm.nih.gov/22749444/Journal Paper
Efficient human fetal liver cell isolation protocol based on vascular perfusion for liver cell-based therapy and case report on cell transplantationLiver Transpl. 2012 Feb;18(2):226-37. doi: 10.1002/lt.22322.
https://pubmed.ncbi.nlm.nih.gov/22034152/Journal Paper
Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La moduleLuigi Martino , Simon Pennell , Geoff Kelly , Baptiste Busi , Paul Brown , Robert Andrew Atkinson , Nicholas J.H. Salisbury , Zi-Hao Ooi , Kang-Wei See , Stephen J. Smerdon , Caterina Alfano, PhD , Tam T.T. Bui , Maria Rosaria Conte
Nucleic Acids Research, 43(1):645-660, 2015
https://doi.org/10.1093/nar/gku1287Progetto di ricerca
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PROSTHETIC HEART VALVEGaetano Burriesci, PhD , Selim Bozkurt , Benyamin Rahmani , Michael J. Mullen
European Patent N. EP3310301 (GRANTED)
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Journal Paper
Regenerating A Kidney In A Lymph NodeMaria Giovanna Francipane, Ph.D. , Eric Lagasse
Pediatric Nephrology, 31(10): 1553–1560, 2016
https://doi.org/10.1007/s00467-015-3296-yProgetto di ricerca
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Maturation Of Embryonic Tissue In A Lymph Node: A New Approach For Bioengineering Complex OrgansMaria Giovanna Francipane, Ph.D. , Eric Lagasse
Organogenesis, 10(3):323-31, 2014
https://doi.org/10.1080/15476278.2014.995509Progetto di ricerca
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Pledget-armed sutures affect the hemodynamic performance of biologic aortic valve substitutes: a preliminary experimental and computational studyClaudio Capelli †, Chiara Corsini , Dario Biscarini , Francesco Ruffini , Francesco Migliavacca , Alfred Kocher , Guenther Laufer , Andrew M. Taylor , Silvia Schievano , Martin Andreas , Gaetano Burriesci, PhD , Claus Rath
Cardiovascular Engineering and Technology, 8(1): 17-29, 2017.
https://doi.org/10.1007/s13239-016-0284-8Progetto di ricerca
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Finite Element Analysis of Transcatheter Aortic Valve Implantation in the Presence of Aortic Leaflet CalcificationsAnnalisa Dimasi , Marco Stevanella , Emiliano Votta , Francesco Sturla , Gaetano Burriesci, PhD , Alberto Redaelli
Biomedical Technology: Lecture Notes in Applied and Computational Mechanics, ed. F Pfeiffer and P Wriggers (2015 ed. 187 pages). Springer pp. 101-116, 2015.
https://doi.org/10.1007/978-3-319-10981-7_7Progetto di ricerca
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Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives
Chiara Cipollina, PhD , Salvatore, Sonia R , Muldoon, Matthew F , Freeman, Bruce A , Schopfer, Francisco J
PLoS ONE
https://doi.org/10.1371/journal.pone.0094836Progetto di ricerca
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mTOR Pathway in Colorectal Cancer: An UpdateMaria Giovanna Francipane, Ph.D. , Eric Lagasse
Oncotarget, 5(1):49-66, 2014
https://doi.org/10.18632/oncotarget.1548Progetto di ricerca
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Dissemination
Procedure to integrate i2b2 and REDCap: a case study at ICSM
Valentina Tibollo , Mauro Bucalo , Danila Vella, PhD *, Morena Stuppia , Nicola Barbarini , Riccardo Bellazzi
PeerJ, 5: e3294v1, 2017
https://doi.org/10.7287/peerj.preprints.3294v1Progetto di ricerca
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Syntheses of new tuberculosis inhibitors promoted by microwave irradiation
Maria De Rosa, PhD , Johan Gising , Luke R. Odell , Mats Larhed
Upsala Journal of Medical Sciences, 119: 181–191, 2014
https://doi.org/10.3109/03009734.2014.899655Progetto di ricerca
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Hemodynamics in the Valsalva sinuses after transcatheter aortic valve implantation (TAVI)Andrea Ducci †, Spyridon Tzamtzis , Michael J Mullen , Gaetano Burriesci, PhD *
Journal of Heart Valve Disease, 22(5): 688-696, 2013.
https://pubmed.ncbi.nlm.nih.gov/24383382/Progetto di ricerca
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Uniaxial and buckling mechanical response of auxetic cellular tubesNicholas Karnessis †, Gaetano Burriesci, PhD *
Smart Materials and Structures, 22(8): 084008, 2013.
https://iopscience.iop.org/article/10.1088/0964-1726/22/8/084008Progetto di ricerca
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Polymeric Heart ValvesBenyamin Rahmani , Hossein Ghanbari , Spyridon Tzamtzis , Gaetano Burriesci, PhD , Alexander M. Seifalian
In Encyclopedia of Biophysics (2013 ed. 2807 pages). New York: Springer Reference, pp. 1893-1900, 2013.
https://doi.org/10.1007/978-3-642-16712-6_702Patent
PROSTHESIS DELIVERY SYSTEMGaetano Burriesci, PhD , Spyridon Tzamtzis , Alexander Seifalian
US Patent N. US20130296999 (GRANTED)
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Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation
Chiara Cipollina, PhD , Di Vincenzo, Serena , Gerbino, Stefania , Siena, Liboria , Gjomarkaj, Mark , Pace, Elisabetta
Biochimica et Biophysica Acta - General Subjects
https://doi.org/10.1016/j.bbagen.2014.02.024Progetto di ricerca
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Comparative cytoprotective effects of carbocysteine and fluticasone propionate in cigarette smoke extract-stimulated bronchial epithelial cells
Pace, Elisabetta , Ferraro, Maria , Di Vincenzo, Serena , Chiara Cipollina, PhD , Gerbino, Stefania , Cigna, Diego , Caputo, Valentina , Balsamo, Rossella , Lanata, Luigi , Gjomarkaj, Mark
Cell Stress and Chaperones
https://doi.org/10.1007/s12192-013-0424-0Progetto di ricerca
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TLR4 Up-regulation and reduced Foxp3 expression in mechanically ventilated smokers with obstructive chronic bronchitis
Pace, Elisabetta , Ferraro, Maria , Giarratano, Antonino , Chiara Cipollina, PhD , Gjomarkaj, Mark
COPD: Journal of Chronic Obstructive Pulmonary Disease
https://doi.org/10.3109/15412555.2012.730565Progetto di ricerca
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MINIMALLY-INVASIVE CARDIAC-VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD
US Patent N. US9867695B2 - GRANTED
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Patent
CARDIAC VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini
US Patent N. US8920492B2 - GRANTED
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Cancer Stem Cells: A Moving TargetMaria Giovanna Francipane, Ph.D. , Julie Chandler , Eric Lagasse
Current Pathobiology Reports, 1(2): 111–118, 2013
https://doi.org/10.1007/s40139-013-0010-2Progetto di ricerca
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Selective Targeting of Human Colon Cancer Stem-Like Cells by the mTOR Inhibitor Torin-1Maria Giovanna Francipane, Ph.D. , Eric Lagasse
Oncotarget, 4(11):1948-62, 2013
https://doi.org/10.18632/oncotarget.1310Progetto di ricerca
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Journal Paper
New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains
Valentina Guerrini , Maria De Rosa, PhD †, Serena Pasquini , Claudia Mugnaini , Antonella Brizzi , Anna Maria Cuppone , Gianni Pozzi , Federico Corelli
Tuberculosis, 93: 405-411, 2013
http://dx.doi.org/10.1016/j.tube.2013.02.017Progetto di ricerca
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Book/Book Chapter
A Study of Cancer Heterogeneity: From Genetic Instability to Epigenetic Diversity in Colorectal CancerMaria Giovanna Francipane, Ph.D. , Eric Lagasse
In: “Cancer Targeted Drug Delivery: Elusive Dream”. (eds You Han Bae, Randall J. Mrsny, & Kinam Park). Springer New York, XVII, 363-388, 2013
https://doi.org/10.1007/978-1-4614-7876-8_14Progetto di ricerca
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ComiR: combinatorial microRNA target prediction toolClaudia Coronnello, PhD , Panayiotis V. Benos
Nucleic Acid Research, 41(W1):W159-W164, 2013
https://doi.org/10.1093/nar/gkt379Journal Paper
Expression of regulatory platelet microRNAs in patients with sickle cell diseaseShilpa Jain , Maria G. Kapetanaki , Nalini Raghavachari , Kimberly Woodhouse , Guoying Yu , Suchitra Barge , Claudia Coronnello, PhD , Panayiotis V. Benos , Gregory J. Kato , Naftali Kaminski , Mark T. Gladwin
PloS ONE, 8(4):e60932, 2013
https://doi.org/10.1371/journal.pone.0060932Journal Paper
The Lymph Node As A New Site For Kidney OrganogenesisMaria Giovanna Francipane, Ph.D. , Eric Lagasse
Stem Cells Translational Medicine, 4(3):295-307, 2015
https://doi.org/10.5966/sctm.2014-0208Progetto di ricerca
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Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditisAntonella Marino Gammazza , Manfredi Rizzo , Roberto Citarrella , Francesca Rappa , Claudia Campanella , Fabio Bucchieri , Angelo Patti , Dragana Nikolic , Daniela Cabibi , Giandomenico Amico, PhD , Pier Giulio Conaldi , Pier Luigi San Biagio , Giuseppe Montalto , Felicia Farina , Giovanni Zummo , Everly Conway de Macario , Alberto J. L. Macario , Francesco Cappello *
Cell Stress Chaperones. 2014 May;19(3):343-53. doi: 10.1007/s12192-013-0460-9.
https://link.springer.com/article/10.1007/s12192-013-0460-9Progetto di ricerca
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2-cinnamamido-2-3-phenylpropiolamido-and-2-3-phenylpropanamidobenzamides-synthesis-antiproliferative-activity-and-mechanism-of-actionDemetrio Raffa *, Benedetta Maggio , Maria Valeria Raimondi , Maria Grazia Cusimano , Giandomenico Amico, PhD , Anna Carollo , Pier Giulio Conaldi , Ruoli Bai , Ernest Hamel , Giuseppe Daidone
Eur J Med Chem. 2013 Jul:65:427-35. doi:10.1016/j.ejmech.2013.04.068. Epub 2013 May 14.
https://www.sciencedirect.com/science/article/pii/S0223523413003012?via%3DihubProgetto di ricerca
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Lipid Nanocarriers Containing Ester Prodrugs of Flurbiprofen Preparation, Physical-Chemical Characterization and Biological Studies
Maria Luisa Bondì , Emanuela Fabiola Craparo , Pasquale Picone , Gaetano Giammona , Roberto Di Gesù, PhD , Marta Di Carlo
Journal od Biomedical Nanotechnology, 9(2): 238-246, 2013
https://doi.org/10.1166/jbn.2013.1490Journal Paper
Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4AJohn Fintan Darby , Ewelina Maria Krysztofinska , Peter J. Simpson , Aline C. Simon , Pawel Leznicki , Newran Sriskandarajah , David S. Bishop , Lisa R. Hale , Caterina Alfano, PhD , Maria Rosaria Conte , Santiago Martínez-Lumbreras , Arjun Thapaliya , Stephen High , Rivka L. Isaacson
PLoS One, 9(11):e113281, 2014
https://doi.org/10.1371/journal.pone.0113281Progetto di ricerca
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Patent
PROSTHESIS DELIVERY SYSTEMGaetano Burriesci, PhD , Spyridon Tzamtzis , Alexander Seifalian
European Patent N. EP2629700 (GRANTED)
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Journal Paper
Development of a standardized model for liver failure in pigs: anatomopathophysiologic findings after extended liver resectionD Pagano *, F di Francesco , G J Echeverri , M de Martino , C Ricotta , G Occhipinti , Valeria Pagano, PhD , E Oliva , M I Minervini , B G Gridelli , M Spada
https://pubmed.ncbi.nlm.nih.gov/22974899/
https://doi.org/10.1016/j.transproceed.2012.06.009Progetto di ricerca
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Pandemic influenza A/H1N1 virus in a swine farm house in Sicily, ItalyA.Guercio *, G.Purpari , Pg. Conaldi , Valeria Pagano, PhD , A.Moreno , P.Giambruno , L.Di Trani , G.Vaccari , E.Falcone , A.Boni , P.Cordioli
https://www.researchgate.net/publication/232006178_Pandemic_influenza_AH1N1_virus_in_a_swine_farm_house_in_Sicily_Italy
https://www.researchgate.net/publication/232006178_Pandemic_influenza_AH1N1_virus_in_a_swine_farm_house_in_Sicily_ItalyProgetto di ricerca
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Partial portal vein ligation: a porcine model for the study of pre-hepatic portal hypertension Marco Spada *, D.Pagano , D.Cintorino , Valeria Pagano, PhD , R.Liotta , B.Gridelli
https://www.researchgate.net/publication/297881576_PARTIAL_PORTAL_VEIN_LIGATION_A_PORCINE_MODEL_FOR_THE_STUDY_OF_PRE-HEPATIC_PORTAL_HYPERTENSIONProgetto di ricerca
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HEART VALVE PROSTHESISGaetano Burriesci, PhD , Alexander M. Seifalian , Constantinos Zervides
US Patent N. US20120165929 (GRANTED)
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A Technical Review of Minimally Invasive Mitral Valve ReplacementsGeorgia L. Preston-Maher †, Ryo Torii , Gaetano Burriesci, PhD *
Cardiovascular Engineering and Technology, 6(2):174-184, 2016
https://doi.org/10.1007/s13239-014-0203-9Progetto di ricerca
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A novel aortic valve prosthesis made of a new nanocomposite polymer: hydrodynamic assessmentBenyamin Rahmani , Spyridon Tzamtzis , Hossein Ghanbari , Gaetano Burriesci, PhD , Alexander M. Seifalian
Cardiology, 121(2):132-133, 2012.
https://doi.org/10.1159/000337671Progetto di ricerca
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Manufacturing and hydrodynamic assessment of a novel aortic valve made of a new nanocomposite polymerBenyamin Rahmani , Spyridon Tzamtzis , Hossein Ghanbari , Gaetano Burriesci, PhD , Alexander M. Seifalian
Journal of Biomechanics, 45(7):1205-1211, 2012.
https://doi.org/10.1016/j.jbiomech.2012.01.046Progetto di ricerca
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Patent
PROSTHESIS DELIVERY SYSTEMGaetano Burriesci, PhD , Spyridon Tzamtzis , Alexander Seifalian
In ternational Patent Application N. WO/2012/052718
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Patent
PROTESIS PARA ANULOPLASTIAGiovanni Bergamasco , Gaetano Burriesci, PhD , Carla Stacchino
Spanish Patent Publication N. ES2376885
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Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
Xiao Yun Chen , Seong Jun Park , Helmut Buschmann , Maria De Rosa, PhD , Carsten Bolm
Bioorganic & Medicinal Chemistry Letters, 22: 4307–4309, 2012
https://doi.org/10.1016/j.bmcl.2012.05.018Progetto di ricerca
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Journal Paper
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors
Serena Pasquini , Maria De Rosa, PhD , Alessia Ligresti , Claudia Mugnaini , Antonella Brizzi , Nicola P. Caradonna , Maria Grazia Cascio , Daniele Bolognini , Roger G. Pertwee , Vincenzo Di Marzo , Federico Corelli
European Journal of Medicinal Chemistry, 58: 30-43, 2012
http://dx.doi.org/10.1016/j.ejmech.2012.09.035Progetto di ricerca
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Journal Paper
Synthesis of P1′-Functionalized Macrocyclic Transition-State Mimicking HIV‑1 Protease Inhibitors Encompassing a Tertiary Alcohol
Maria De Rosa, PhD , Johan Unge , Hitesh V. Motwani , Åsa Rosenquist , Lotta Vrang , Hans Wallberg , Mats Larhed
Journal of Medicinal Chemistry, 57: 6444−6457, 2014
https://doi.org/10.1021/jm500434q Progetto di ricerca
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Book/Book Chapter
Lipid nanoparticles for drug targeting to the brain
Maria Luisa Bondì , Roberto Di Gesù, PhD , Emanuela Fabiola Craparo
Methods in enzymology, 508:229-251, 2012
https://doi.org/10.1016/B978-0-12-391860-4.00012-4Journal Paper
Novel modeling of combinatorial miRNA targeting identifies SNP with potential role in bone densityClaudia Coronnello, PhD , Ryan Hartmaier , Arshi Arora , Luai Huleihel , Kusum V. Pandit , Abha S. Bais , Michael Butterworth , Naftali Kaminski , Gary D. Stormo , Steffi Oesterreich , Panayiotis V. Benos
PloS Computational Biology, 8(12):e1002830, 2012
https://doi.org/10.1371/journal.pcbi.1002830Journal Paper
Formation and signaling actions of electrophilic lipids
Schopfer, Francisco J , Cipollina, Chiara , Freeman, Bruce A
Chemical Reviews
https://doi.org/10.1021/cr200131eProgetto di ricerca
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Patent
EXPANDABLE PROSTHETIC VALVE CRIMPING DEVICEGiovanni Righini , Giovanni Bergamasco , Gaetano Burriesci, PhD
US Patent N. US8640521B2 - GRANTED
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Patent
CARDIAC VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini
US Patent N. US8540768B2 - GRANTED
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Patent
CARDIAC-VALVE PROSTHESISGiovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini , Carla Stacchino
European Patent N. EP2319458B1 - GRANTED
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Journal Paper
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions
Claudia Mugnaini , Chiara Falciani , Maria De Rosa, PhD , Antonella Brizzi , Serena Pasquini , Federico Corelli
Tetrahedron, 67 : 5776-5783, 2011
https://doi.org/10.1016/j.tet.2011.05.134Progetto di ricerca
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Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice
Serena Pasquini , Maria De Rosa, PhD , Valentina Pedani , Claudia Mugnaini , Francesca Guida , Livio Luongo , Maria De Chiaro , Sabatino Maione , Stefania Dragoni , Maria Frosini , Alessia Ligresti , Vincenzo Di Marzo , Federico Corelli
Journal of Medicinal Chemistry, 54: 5444–5453, 2011
https://doi.org/10.1021/jm200476pProgetto di ricerca
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Overexpression of microRNA-1 promotes cardiomyocyte commitment from human cardiovascular progenitors via suppressing WNT and FGF signaling pathwaysTung-Ying Lu , Bo Lin , Yang Li , Arshi Arora , Lu Han , Cheng Cui , Claudia Coronnello, PhD , Yi Sheng , Panayiotis V. Benos , Lei Yang
Journal of Molecular and Cellular Cardiology, 63:146-154, 2013
https://doi.org/10.1016/j.yjmcc.2013.07.019Journal Paper
Management Of Liver Failure: From Transplantation To Cell-Based TherapyMaria Giovanna Francipane, Ph.D. , Melchiorre Cervello , Giovanni Battista Vizzini , Giada Pietrosi , Giuseppe Montalto
Cell Medicine: Part B of Cell Transplantation, 2(1):9-25, 2011
https://doi.org/doi: 10.3727/215517911X575993Journal Paper
Prolactin supplementation to culture medium improves beta-cell survivalToshiyuki Yamamoto †, Atsuyoshi Mita , Camillo Ricordi , Shari Messinger , Atsushi Miki , Yasunaru Sakuma , Francesca Timoneri, PhD , Scott Barker , Alessia Fornoni , R Damaris Molano , Luca Inverardi , Antonello Pileggi , Hirohito Ichii
https://journals.lww.com/transplantjournal/fulltext/2010/06150/prolactin_supplementation_to_culture_medium.6.aspxProgetto di ricerca
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A New Generation Transcatheter Heart Valve with a Novel Nanocomposite Material and Fully Retrievable DesignBenyamin Rahmani , Gaetano Burriesci, PhD , Michael Mullen , Alexander Seifalian , Spyros Tzamtzis , John Yap
JACC: Cardiovascular Interventions, 60(17): B34, 2012.
https://doi.org/10.1016/j.jacc.2012.08.126Progetto di ricerca
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Mitral Valve dynamics in structural and fluid-structure interaction modelsMedical Engineering and Physics, 32(9-2):1057-1064, 2010.
https://doi.org/10.1016/j.medengphy.2010.07.008Progetto di ricerca
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Design of a novel polymeric heart valveGaetano Burriesci, PhD ‡, Fabrizio Cavallo Marincola , Constantinos Zervides
Journal of Medical Engineering & Technology, 34(1): 7-22, 2010.
https://doi.org/10.3109/03091900903261241Progetto di ricerca
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Journal Paper
Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae
Wisselink, H. Wouter , Chiara Cipollina, PhD , Oud, Bart , Crimi, Barbara , Heijnen, Joseph J. , Pronk, Jack T , van Maris, Antonius J.A
Metabolic Engineering
https://doi.org/10.1016/j.ymben.2010.08.003Progetto di ricerca
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Journal Paper
Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids
Groeger, Alison L , Chiara Cipollina, PhD , Cole, Marsha P , Woodcock, Steven R , Bonacci, Gustavo , Rudolph, Tanja K , Rudolph, Volker , Freeman, Bruce A , Schopfer, Francisco J
Nature Chemical Biology
https://doi.org/10.1038/nchembio.367Progetto di ricerca
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Patent
VASCULAR IMPLANTGaetano Burriesci, PhD , Spyridon Tzamtzis , Michael John Mullen , Alexander Seifalian , John Yap
International Patent Publication N. WO2015036790
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Journal Paper
Colon Cancer Stem Cells: Promise of Targeted TherapyTodaro Matilde , Maria Giovanna Francipane, Ph.D. , Jan Paul Medema , Giorgio Stassi
Gastroenterology, 138(6):2151-6, 2010
https://doi.org/10.1053/j.gastro.2009.12.063Progetto di ricerca
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Book/Book Chapter
Identification, Isolation and In Vitro Expansion of Colon Cancer Initiating Cells
Maria Giovanna Francipane, Ph.D. , Lombardo Ylenia , Iovino Flora , Gaspare Gulotta , Matilde Todaro , Giorgio Stassi
In: Cancer Stem Cells. (ed Guan XY). Transworld Research Network, 73-92, 2010
https://doi.org/Progetto di ricerca
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Journal Paper
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure-Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands
Serena Pasquini , Alessia Ligresti , Claudia Mugnaini , Teresa Semeraro , Lavinia Cicione , Maria De Rosa, PhD , Francesca Guida , Livio Luongo , Maria De Chiaro , Maria Grazia Cascio , Daniele Bolognini , Pietro Marini , Roger Pertwee , Sabatino Maione , Vincenzo Di Marzo , Federico Corelli
Journal of Medicinal Chemistry, 53: 5915–5928, 2010
https://doi.org/10.1021/jm100123xProgetto di ricerca
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Journal Paper
Aldosterone Regulates MicroRNAs in the Cortical Collecting Duct to Alter Sodium Transport
Robert S. Edinger , Claudia Coronnello, PhD , Andrew J. Bodnar , William A. LaFramboise , Panayiotis V. Benos , Jacqueline Ho , John P. Johnson , Michael B. Butterworth
Journal of American Society of Nephrology, 25(11):2445-2457, 2016
https://doi.org/10.1681%2FASN.2013090931Articolo di rivista
Numerical analysis of the radial force produced by the Medtronic-CoreValve and Edwards-SAPIEN after transcatheter aortic valve implantation (TAVI)Spyridon Tzamtzis †, Jonathan Viquerat †, John Yap , Michael J Mullen , Gaetano Burriesci, PhD *
Medical Engineering & Physics 35(1): 125-130, 2013.
https://doi.org/10.1016/j.medengphy.2012.04.009Progetto di ricerca
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Fluid-structure interaction study of the edge-to-edge repair technique on the mitral valveJournal of Biomechanics, 44(13):2409-2417, 2011.
https://doi.org/10.1016/j.jbiomech.2011.06.030Progetto di ricerca
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Libro
Self-endothelialisation potential of a novel nanocomposite material for development of cardiovascular implant: the role of progenitor stem cellsHossein Ghanbari , Mahdi Marashi , Raheleh Bakhshi , Gaetano Burriesci, PhD , Alexander Seifalian
Society of Academic & Research Surgery - Yearbook 2010, 51-52.
https://oa.mg/work/1541164192Progetto di ricerca
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Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspectiveVanessa Díaz-Zuccarini †, Andrew J. Narracott , Gaetano Burriesci, PhD , Constantinos Zervides , Dan Rafirou , D. Jones , D. Rod Hose , Patricia V. Lawford
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 367(1898): 2655-2666, 2009.
https://doi.org/10.1098/rsta.2009.0052Progetto di ricerca
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A novel nanocomposite polymer for development of synthetic heart valve leafletsAsmeret G. Kidane , Gaetano Burriesci, PhD , Mohan Edirisinghe , Hossein Ghanbari , Philipp Bonhoeffer , Alexander M. Seifalian
Acta Biomaterialia, 5(7): 2409-2417, 2009.
https://doi.org/10.1016/j.actbio.2009.02.025Progetto di ricerca
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Manufacture of small calibre quadruple lamina vascular bypass grafts using a novel automated extrusion-phase-inversion method and nanocomposite polymerSandip Sarkar , Gaetano Burriesci, PhD , Adam Wojcik , Nicholas Aresti , George Hamilton , Alexander M. Seifalian
Journal of Biomechanics, 42(6): 722-730, 2009.
https://doi.org/10.1016/j.jbiomech.2009.01.003Progetto di ricerca
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Journal Paper
A comprehensive method for the quantification of the non-oxidative pentose phosphate pathway intermediates in Saccharomyces cerevisiae by GC-IDMS
Chiara Cipollina, PhD , ten Pierick, Angela , Canelas, André B , Seifar, Reza M , van Maris, Antonius J.A. , van Dam, Jan C , Heijnen, Joseph J
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
https://doi.org/10.1016/j.jchromb.2009.07.019Progetto di ricerca
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Patent
HERZKLAPPENPROTHESEGiovanni Bergamasco , Gaetano Burriesci, PhD , Carla Stacchino
AT Publication N. AT420612
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Patent
EXPANDABLE PROSTHETIC VALVE CRIMPING DEVICEGiovanni Righini , Giovanni Bergamasco , Gaetano Burriesci, PhD
US Patent N. US8006535B2 - GRANTED
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Patent
ANNULOPLASTIEPROTHESEGiovanni Bergamasco , Gaetano Burriesci, PhD , Carla Stacchino
Austrian Patent Publication N. AT534346
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Journal Paper
Efficient Killing of Human Colon Cancer Stem Cells by gamma delta T LymphocytesMatilde Todaro , Matilde D'Asaro , Nadia Caccamo , Flora Iovino , Maria Giovanna Francipane, Ph.D. , Serena Meraviglia , Valentina Orlando , Carmela La Mendola , Gaspare Gulotta , Alfredo Salerno , Francesco Dieli , Giorgio Stassi
Journal of Immunology, 182(11):7287-96, 2009
https://doi.org/doi: 10.4049/jimmunol.0804288Progetto di ricerca
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Journal Paper
Estrogen represses gene expression through reconfiguring chromatin structuresHatice Ulku Osmanbeyoglu , Kevin N. Lu , Steffi Oesterreich , Roger S. Day , Panayiotis V. Benos , Claudia Coronnello, PhD , Xinghua Lu
Nucleic Acid Research, 41(17):8061-8071, 2013
https://doi.org/10.1093/nar/gkt586Journal Paper
Networks in biological systems: An investigation of the Gene Ontology as an evolving network
Claudia Coronnello, PhD , Michele Tumminello , Salvatore Micciché ,
Il nuovo cimento C, 32(2):157-160, 2009
https://doi.org/10.1393/ncc/i2009-10386-7Progetto di ricerca
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Journal Paper
Saccharomyces cerevisiae SFP1: At the crossroads of central metabolism and ribosome biogenesis
Chiara Cipollina, PhD , van den Brink, Joost , Daran-Lapujade, Pascale , Pronk, Jack T , Porro, Danilo , de Winde, Johannes H.
Microbiology
https://doi.org/10.1099/mic.0.2008/017392-0Progetto di ricerca
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Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: A chemostat study
Chiara Cipollina, PhD , van den Brink, Joost , Daran-Lapujade, Pascale , Pronk, Jack T , Vai, Marina , de Winde, Johannes H
Microbiology
https://doi.org/10.1099/mic.0.2007/011767-0Progetto di ricerca
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Patent
MINIMALLY-INVASIVE CARDIAC-VALVE PROSTHESISCarla Stacchino , Bergamasco Giovanni , Gaetano Burriesci, PhD
US Patent N. US8535373B2 - GRANTED
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Patent
CARDIAC-VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini
US Patent N. US8539662B2 - GRANTED
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Patent
CARDIAC-VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini
US Patent N. US8539662B2 - GRANTED
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Patent
CARDIAC-VALVE PROSTHESISGiovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini , Carla Stacchino
European Patent N. EP1913901B1 - GRANTED
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Patent
HERZKLAPPENPROTHESEGiovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini , Carla Stacchino
Austrian Patent Publication N. AT402672
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Journal Paper
Crucial Role of IL-4 in the Survival of Cancer Stem CellsMaria Giovanna Francipane, Ph.D. , Mileidys Perez Alea , Ylenia Lombardo , Matilde Todaro , Jan Paul Medema , Giorgio Stassi
Cancer Research, 68(11):4022-5, 2008
https://doi.org/doi: 10.1158/0008-5472.CAN-07-6874Progetto di ricerca
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Apoptosis Resistance in Epithelial Tumors is Mediated by Tumor Cell-derived Interleukin-4Matilde Todaro , Ylenia Lombardo , Maria Giovanna Francipane, Ph.D. , Mileidys Perez Alea , Patrizia Cammareri , Flora Iovino , Anna Barbara Di Stefano , Cristofaro Di Bernardo , Antonino Agrusa , Gianluigi Condorelli , Henning Walczak , Giorgio Stassi
Cell Death and Differentiation, 15(4):762-72, 2008
https://doi.org/10.1038/sj.cdd.4402305Progetto di ricerca
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Isolation and Culture of Colon Cancer Stem Cells. Methods in Cell BiologyPatrizia Cammareri , Ylenia Lombardo , Maria Giovanna Francipane, Ph.D. , Sebastino Bonventre , Matilde Todaro , Giorgio Stassi
Methods in Cell Biology, 86:311-24, 2008
https://doi.org/10.1016/S0091-679X(08)00014-9Progetto di ricerca
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Journal Paper
CD40 activation in human pancreatic islets and ductal cellsD Klein †, Francesca Timoneri, PhD , H Ichii , C Ricordi , R L Pastori
https://link.springer.com/article/10.1007/s00125-008-1092-yProgetto di ricerca
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CD40 activation in human pancreatic islets and ductal cells.
Francesca Timoneri, PhD *, Dagmar Klein *, Hiroito Ichii , Camillo Ricordi , Ricardo Pastori
https://link.springer.com/article/10.1007/s00125-008-1092-yProgetto di ricerca
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HEART VALVE PROSTHESISGaetano Burriesci, PhD , Alexander M. Seifalian , Constantinos Zervides
International Patent Application N. WO2010112844
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Polymeric heart valves: new materials, emerging hopesHossein Ghanbari †, Helene Viatge , Asmeret G. Kidane , Gaetano Burriesci, PhD , Mehdi Tavakoli , Alexander M. Seifalian *
Trends in Biotechnology, 27(6): 329-384, 2009.
https://doi.org/10.1016/j.tibtech.2009.03.002Progetto di ricerca
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Percutaneous Heart Valve Replacement: An UpdateHossein Ghanbari , Asmeret G. Kidane , Gaetano Burriesci, PhD , Philipp Bonhoeffer , Alexander M. Seifalian
Trends in Cardiovascular Medicine, 18(4): 117-125, 2008.
https://doi.org/10.1016/j.tcm.2008.02.002Progetto di ricerca
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Towards understanding of the complex structure of growing yeast populations
Chiara Cipollina, PhD , Vai, Marina , Porro, Danilo , Hatzis, Christos
Journal of Biotechnology
https://doi.org/10.1016/j.jbiotec.2006.10.012Progetto di ricerca
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ANNULOPLASTY PROSTHESIS WITH AN AUXETIC STRUCTUREGaetano Burriesci, PhD , Giovanni Bergamasco
European Patent N. EP1803420B1 - GRANTED
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Patent
ANNULOPLASTY PROSTHESIS WITH AN AUXETIC STRUCTUREGaetano Burriesci, PhD , Giovanni Bergamasco
US Patent N. US8034103B2 - GRANTED
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Journal Paper
Suppressor of Cytokine Signaling 3 Sensitizes Anaplastic Thyroid Cancer to Standard ChemotherapyMaria Giovanna Francipane, Ph.D. , Vincenzo Eterno , Valentina Spina , Miriam Bini , Gregorio Scerrino , Giuseppe Buscemi , Gaspare Gulotta , Matilde Todaro , Francesco Dieli , Ruggero De Maria , Giorgio Stassi
Cancer Research, 69(15):6141-8, 2009
https://doi.org/doi: 10.1158/0008-5472.CAN-09-0994Progetto di ricerca
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MUC1 Oncoprotein Promotes Refractoriness to Chemotherapy in Thyroid Cancer CellsMauro Siragusa , Monica Zerilli , Flora Iovino , Maria Giovanna Francipane, Ph.D. , Ylenia Lombardo , Lucia Ricci-Vitiani , Giuseppe Di Gesù , Matilde Todaro , Ruggero De Maria , Giorgio Stassi
Cancer Research, 67(11):5522-30, 2007
https://doi.org/doi: 10.1158/0008-5472.CAN-06-4197Progetto di ricerca
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Journal Paper
Role Of Th Cytokines In Thyroid Autoimmunity
Maria Giovanna Francipane, Ph.D. , Ylenia Lombardo , Attilio Ignazio Lo Monte , Matilde Todaro , Giorgio Stassi
Current Trends in Immunology, 8:69-73, 2007
https://doi.org/Progetto di ricerca
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Journal Paper
Spanning trees and bootstrap reliability estimation in correlation-based networksMichele Tumminello , Claudia Coronnello, PhD , Fabrizio Lillo , Salvatore Micciché , Rosario N. Mantegna
International Journal of Bifurcation and Chaos, 17(7):2319-2329, 2007
https://doi.org/10.1142/S0218127407018415Progetto di ricerca
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Patent
CARDIAC-VALVE PROSTHESISGiovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini , Carla Stacchino
European Patent N. EP1690515B1 - GRANTED
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Patent
ANNULOPLASTY PROSTHESISGiovanni Bergamasco , Gaetano Burriesci, PhD , Carla Stacchino
European Patent N. EP1719476B1 - GRANTED
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Journal Paper
A new mutant of bovine seminal ribonuclease with a reversed swapping propensityCarmine Ercole , Roberta Spadaccini , Caterina Alfano, PhD , Teodorico Tancredi , Delia Picone
Biochemistry, 46(8):2227-2232, 2007
https://doi.org/10.1021/bi0613630Progetto di ricerca
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Patent
CARDIAC-VALVE PROSTHESISGiovanni Bergamasco , Gaetano Burriesci, PhD , Carla Stacchino
European Patent N. EP1570809B1 - GRANTED
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Journal Paper
Sector identification in a set of stock return time series traded at the London Stock Exchange
Claudia Coronnello, PhD , Michele Tumminello , Fabrizio Lillo , Salvatore Micciché , Rosario N. Mantegna
ACTA PHYSICA POLONICA B, 36(9):2653-2679, 2005
https://doi.org/10.48550/arXiv.cond-mat/0508122Progetto di ricerca
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Journal Paper
SFPI is involved in cell size modulation in respiro-fermentative growth conditions
Chiara Cipollina, PhD , Alberghina, Lilia , Porro, Danilo , Vai, Marina
Yeast
https://doi.org/10.1002/yea.1218Progetto di ricerca
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Journal Paper
Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La proteinCaterina Alfano, PhD , Domenico Sanfelice , Jeff Babon , Geoff Kelly , Amanda Jacks , Stephen Curry , Maria Rosaria Conte
Nature Structural and Molecular Biology, 11(4):323-329, 2004
https://doi.org/10.1038/nsmb747Progetto di ricerca
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The swapping of terminal arms in ribonucleases: comparison of the solution structure of monomeric bovine seminal and pancreatic ribonucleasesFrancesca Avitabile , Caterina Alfano, PhD , Roberta Spadaccini , Orlando Crescenzi , Anna Maria D'Ursi , Giuseppe D'Alessi , Teodorico Tancredi , Delia Picone
Biochemistry, 42(29):8704-8711, 2003
https://doi.org/10.1021/bi0342517Progetto di ricerca
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Journal Paper
Resonance assignment and secondary structure of an N-terminal fragment of the human La protein
Caterina Alfano, PhD , Jeff Babon , Geoff Kelly , Stephen Curry , Maria Rosaria Conte
Journal of Biomolecular NMR, 27(1):93-94, 2003
https://doi.org/10.1023/a:1024741228802Progetto di ricerca
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An approach to the simulation of fluid–structure interaction in the aortic valve
Christopher J. Carmody , Gaetano Burriesci, PhD , Ian C. Howard , Eann A. Patterson
Journal of Biomechanics, 39(1): 158-169, 2006.
https://doi.org/10.1016/j.jbiomech.2004.10.038Progetto di ricerca
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Patent
MINIMALLY-INVASIVE CARDIAC-VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD
US Patent N. US8109996B2 - GRANTED
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Computer aided photoelasticity by an optimum phase stepping methodSandro Barone , Gaetano Burriesci, PhD , Giovanni Petrucci
Experimental Mechanics, 42(2): 132-139, 2002.
https://doi.org/10.1007/BF02410874Progetto di ricerca
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Patent
CARDIAC-VALVE PROSTHESISCarla Stacchino , Giovanni Bergamasco , Gaetano Burriesci, PhD , Giovanni Righini
US Patent N. US7857845B2 - GRANTED
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Mechanical and electromagnetic behaviour of auxetic honeycomb structuresFabrizio Scarpa , Frank C. Smith , Barry Chambers , Gaetano Burriesci, PhD
The Aeronautical Journal, 107(1069), 175-183, 2003.
https://doi.org/10.1017/S000192400001191XProgetto di ricerca
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Journal Paper
Influence of anisotropy on the mechanical behaviour of bioprosthetic heart valvesGaetano Burriesci, PhD , Ian C. Howard , Eann A. Patterson
Journal of Medical Engineering and Technology, 23(6): 203-215, 1999.
https://doi.org/10.1080/030919099294050Progetto di ricerca
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