Antonio D'Amore, PhD
Group Leader in Tissue Engineering
adamore@fondazionerimed.com
Cenni biografici
Il Prof. Antonio D’Amore è responsabile di gruppo di ruolo e direttore del laboratorio di Ingegneria dei Tessuti Cardiovascolari presso la Fondazione Ri.MED; è inoltre Professore Associato presso i Dipartimenti di Chirurgia e Bioingegneria dell’Università di Pittsburgh e Professore Ordinario (Chiara Fama) presso il Dipartimento di Medicina di Precisione dell’Area Medica, Chirurgica e Critica dell’Università di Palermo.
Ha conseguito la laurea magistrale in Ingegneria Meccanica presso l’Università di Palermo nel 2004 e ha proseguito gli studi presso l’Imperial College di Londra, ottenendo una laurea magistrale in Ingegneria Biomedica nel 2007. Nel 2011, il Prof. D’Amore ha conseguito il dottorato di ricerca in Biomeccanica e Ingegneria dei Tessuti presso un programma congiunto dell’Università di Palermo e dell’Università di Pittsburgh. Dal 2008 è consulente nel settore della bioingegneria sia negli Stati Uniti che in Italia.
Attività Scientifica
È autore di oltre 244 pubblicazioni, tra cui articoli su riviste sottoposte a revisione paritaria, capitoli di libri, abstract e abstract estesi di conferenze internazionali, domande di brevetto, brevetti rilasciati negli Stati Uniti e nell’Unione Europea (13) e software per la modellizzazione di sistemi biologici. Il valore di questa proprietà intellettuale è stato riconosciuto da diverse associazioni professionali, dalla scienza traslazionale e da premi alla carriera come la National Academy of Inventors (membro senior), il premio “Strazzabosco” per giovani ingegneri assegnato sotto il patrocinio del Presidente della Repubblica Italiana e il premio Coulter’s Foundation Translational Research. In qualità di PI o Co-I, ha ottenuto numerosi premi di ricerca, che hanno garantito un finanziamento complessivo di oltre 19,9 milioni di dollari, tra cui: NIH-R01, NIH-STTR, ERC-CoG e ERC-PoC. Il Prof. D’Amore è co-fondatore, membro del consiglio di amministrazione e Chief Technology Officer di “Neoolife”, la prima startup Ri.MED-UPMC che si occupa di tecnologia di ingegneria tissutale per valvole cardiache.
Pubblicazioni
Journal Paper
Generation of Human 3D Airway Assembloids for Advanced ModelingIachini M.C. , A. Coglot , D. Tace , N. Elia , F. Rusconi , Federica Cosentino, PhD , G. Lopez , M. Crosti , T.D. Usal , E. Scarpa , Antonio D'Amore, PhD , V. Miceli , L. Rosso , L. Lazzari
International Journal of Biological Sciences
https://doi.org/10.7150/ijbs.113920Progetto di ricerca
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Journal Paper
Photo-oxidation crosslinked, glutaraldehyde crosslinked, or enzyme and hydrostatic pressure processed decellularized biomaterials for cardiovascular repair do not affect host response in a rat right ventricular outflow flow tract reconstruction (RVOT) model
Parnaz Boodagh †, Laura Modica De Mohac, PhD , Yasurani Hayashi , Danila Vella, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Taro Fujii , Emily Gorge , Garrett Coyan , Laubrie Soto Joan Dario, PhD , Gaetano Burriesci, PhD , William R Wagner , Antonio D'Amore, PhD
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(2):e35529, 2025.
https://doi.org/10.1002/jbm.b.35529Progetto di ricerca
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In Vitro Evaluation of Biomaterials for Heart Valve Prosthesis: High Hydrostatic and Enzymatic Treatments as Alternative for Bio-Derived MaterialsDanila Vella, PhD †, Parnaz Boodagh , Laura Modica De Mohac, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Federica Scaglione , Sofia Dei Bardi , Giulia Polizzi , Garrett Coyan , William R. Wagner , Gaetano Burriesci, PhD , Antonio D'Amore, PhD *
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(6): e35592, 2025.
https://doi.org/10.1002/jbm.b.35592Progetto di ricerca
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Intervening to preserve function in ischemic cardiomyopathy with a porous hydrogel and extracellular matrix composite in a rat myocardial infarction model.Y. Hayashi , T. Fujii , S. Kim , T. Ozeki , S. Badylak , Antonio D'Amore, PhD , M. Mutsuga , W.R. Wagner
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202402757Progetto di ricerca
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Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery bandingY. Hayashi , S. Kim , T. Fujii , D.D. Pedersen , T. Ozeki , H. Jiang , Antonio D'Amore, PhD , W.R. Wagner
Frontiers in Bioengineering and Biotechnology
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Engineering a Human-Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune ModulationMattia Pasqua, PhD , Marianna Barbuto , M. Calligaris , Roberto Di Gesù, PhD , D. Pagano , R. Busà , S. Grutadauria , Simone Dario Scilabra, PhD , Antonio D'Amore, PhD , Maria Giovanna Francipane, Ph.D.
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202501660Progetto di ricerca
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Patent
Hybrid Micro Molding-Fiber Deposition Substrate Processing for Cell Biology Manipulation and Local AnisotropyUS patent application PCT/US21/054767
Licensed to Neoolife Inc. in 7-2025
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Journal Paper
Tissue formation and remodeling of acellular elastomeric scaffold in ovine single pulmonary leaflet replacement model.Z. Machaidze , Antonio D'Amore, PhD , R. Freitas , A. J. Joyce , A. Bayoumi , K. Rich , D.W. Brown , E. Aikawa , W. R. Wagner , B. Rego , J. E. Mayer
Journal of Biomedical Materials Research: Part A
https://doi.org/10.1002/jbm.a.37622Progetto di ricerca
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Influence of Polymer Stiffness and Geometric Design on Fluid Mechanics in Tissue Engineered Pulmonary Valve Scaffolds.D. Pedersen , S. Kim , Antonio D'Amore, PhD , W. R. Wagner
Annals of Biomedical Engineering
https://doi.org/10.1007/s10439-023-03401-zProgetto di ricerca
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Open- source Image-based Tool to Experimentally Evaluate Blood Residence Time in Clinical DevicesG. Menallo , R. Miraglia , R. Gerasia , Federica Cosentino, PhD , Pietro Terranova, PhD , Marianna Barbuto , W. R. Wagner , Antonio D'Amore, PhD
ASAIO
https://doi.org/10.1097/mat.0000000000002138Progetto di ricerca
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Redefining vascular repair: revealing cellular responses on PEUU—gelatin electrospun vascular grafts for endothelialization and immune responses on in vitro models M. A. Rodríguez Soto , A. Riverso-Cortes , I. Orjuela-Garzon , I Fernandez-Calderon , C. Rodriguez , N. Suarez Vargas , C. Ostos , C. Muñoz Camargo , J. C. Cruz, , S. Kim , Antonio D'Amore, PhD , W. R. Wagner , J. C. Briceño ,
Frontiers in Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2024.1410863Progetto di ricerca
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A versatile 5-axis melt electrowriting platform for unprecedented design freedom of 3D fibrous scaffoldsPietro Terranova, PhD , K.M.A. Mueller , D. Biebl , Antonio D'Amore, PhD , P. Mela ,
Additive Manufacturing
https://doi.org/10.1016/j.addma.2024.104431Progetto di ricerca
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Cardiac valve scaffold design: Implications of material properties and geometric configuration on performance and mechanicsDrake D. Pedersen , Seungil Kim , Antonio D'Amore, PhD , William R. Wagner
Journal of the Mechanical Behavior of Biomedical Materials
https://doi.org/10.1016/j.jmbbm.2023.106043Progetto di ricerca
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Creating and Transferring an Innervated, Vascularized Muscle Flap Made from an Elastic, Cellularized Tissue Construct Developed In SituHideyoshi Sato , Keishi Kohyama , Takafumi Uchibori , Keisuke Takanari , Johnny Huard , Stephen F Badylak , Antonio D'Amore, PhD , William R. Wagner
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202301335Progetto di ricerca
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Bioengineering an in situ ovary (ISO) for fertility preservationMichael J. Buckenmeyer , Meena Sukhwani , Aimon Iftikhar , Alexis L. Nolfi , Ziyu Xian , Srujan Dadi , Zachary W. Case , Sarah R. Steimer , Antonio D'Amore, PhD , Kyle E. Orwig , Bryan N. Brown
Journal of Tissue Engineering
http://dx.doi.org/10.1177/20417314231197282Progetto di ricerca
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Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modificationsM.A. Rodriguez-Soto , A.M. Aragón , N.A. Suarez , M. Ayala-Velásquez , G. Peralta-Peluffo , J.C. Cruz , C. Muñoz Camargo , S. Kim , Antonio D'Amore, PhD , W.R. Wagner , J.C. Briceño
Frontiers Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2023.1257778Progetto di ricerca
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Engineering Anti-platelet polymers for regenerative cardiovascular applicationsM.A. Rodriguez-Soto , A.M. Aragón , N.A. Suarez , M. Ayala-Velásquez , G. Peralta-Peluffo , J.C. Cruz , C. Muñoz Camargo , S. Kim , Antonio D'Amore, PhD , W.R.Wagner , J.C. Briceño
ASAIO Journal
https://doi.org/10.1097/01.mat.0000943416.83743.94Progetto di ricerca
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Comparative Assessment of Prosthetic Biomaterials for Cardiac ApplicationsDanila Vella, PhD †, Parnaz Boodagh †, Laura Modica De Mohac, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Federica Scaglione , William Wagner , Antonio D'Amore, PhD , Gaetano Burriesci, PhD
Proceedings of the 9th World Congress on Electrical Engineering and Computer Systems and Sciences (EECSS’23), ICBES 137, 2023. DOI: 10.11159/icbes23.137
https://avestia.com/EECSS2023_Proceedings/files/paper/ICBES/ICBES_137.pdfProgetto di ricerca
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Cardiac valve scaffold design: Implications of material properties and geometric configuration on performance and mechanicsDrake D. Pedersen, Ph.D. , Seungil Kim , Antonio D'Amore, PhD , William R. Wagner
Journal of the Mechanical Behavior of Biomedical Materials
https://doi.org/10.1016/j.jmbbm.2023.106043Progetto di ricerca
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A continuous microfibe wire mandrel-less biofabrication for soft tissue engineering applications.
Arianna Adamo, PhD , Joseph G. Bartolacci , Drake D. Pedersen , Marco G. Traina , Seungil Kim , Antonio Pantano , Giulio Ghersi , Simon C. Watkins , William R. Wagner , Stephen F. Badylak , Antonio D'Amore, PhD
Tissue Engineering and Regenerative Medicine International Society (TERMIS) 2021 World Congress.
https://doi.org/10.1002/adhm.202270075Progetto di ricerca
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Blood Vessel Detection Algorithm for Tissue Engineering and Quantitative HistologyArianna Adamo, PhD , A. Bruno , G. Menallo , Maria Giovanna Francipane, Ph.D. , M. Fazzari , E. Ardizzone , W.R. Wagner , Antonio D'Amore, PhD
Annals of Biomedical Engineering
https://doi.org/10.1007/s10439-022-02923-2Progetto di ricerca
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Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment
Zhu T. , Alves S.M. , Arianna Adamo, PhD , Wen X. , Corn K.C. , Shostak A. , Johnson S. , Shaub N.D. , Martello S.E. , Hacker B.C. , Antonio D'Amore, PhD , Bardhan R. , Rafat M.
Biomaterials
https://doi.org/10.1101/2022.05.16.492117Journal Paper
Adipose-derived stem cell sheet under an elastic patch improves cardiac function in rats after myocardial infarction
Noriyuki Kashiyama , Robert L. Kormos , Yasumoto Matsumura , Antonio D'Amore, PhD , Shigeru Miyagawa , Yoshiki Sawa , William R. Wagner
Tissue Engineering Part A,
https://doi.org/10.1016/j.jtcvs.2020.04.150Progetto di ricerca
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Controlling in-plane mechanics of electrospun polyurethane scaffolds for cardiac tissue engineering applications
Samuel K. Luketich , Federica Cosentino, PhD , Marzio Di Giuseppe, PhD , Giorgio Menallo , Gabriele Nasello , Patrizia Livreri , William R. Wagner , Antonio D'Amore, PhD
Journal of Mechanical Behavior of Biomedical Materials
https://doi.org/10.1016/j.jmbbm.2022.105126Progetto di ricerca
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Blood Vessel Detection Algorithm for Tissue Engineering and Quantitative Histology
Arianna Adamo, PhD , A. Bruno , G. Menallo , M. G. Francipane , M. Fazzari , R. Pirrone , E. Ardizzone , W. R. Wagner , Antonio D'Amore, PhD
Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022, Krakow, Poland, June 28th - July 1st 2022.
https://doi.org/10.1007/s10439-022-02923-2Progetto di ricerca
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Processing Method and Apparatus for Micro-Structured Rope-Like MaterialAntonio D'Amore, PhD , Daniel McKeel , William R. Wagner
US Patent issued in 10-2024, publication number: US 12,077,855
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Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?
Lindemberg M Silveira-Filho , Garrett N Coyan , Arianna Adamo , Samuel K Luketich , Giorgio Menallo , Antonio D'Amore, PhD , William R Wagner
https://10.1016/j.jacbts.2021.01.004Progetto di ricerca
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Patent
Transatrial access for intracardiac therapyVinay Badhwar , Antonio D'Amore, PhD , William R. Wagner
US patent issued in 06-29-2021, publication number: US-2021-11045218-A1.
https://patents.google.com/patent/US11045218B2/en?oq=11%2c045%2c218Progetto di ricerca
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Patent
Multi-Layered Graft for Tissue Engineering ApplicationsAntonio D'Amore, PhD , Matteo Solazzo , William R. Wagner
US patent application PCT/US2018/043889
Notice of allowance in 12-12-2025
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Patent
Biodegradable Metallic - Polymeric Composite Prosthesis for Heart Valve ReplacementWilliam R. Wagner , Antonio D'Amore, PhD , Vesselin N. Shanov
US patent application PCT/US2019/029121
Licensed to Neoolife Inc. in 10- 2020.
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A Cell-free Biodegradable Synthetic Artificial Ligament for the Reconstruction of Anterior Cruciate Ligament (ACL) in a Rat ModelY. Kawakami , K. Nonaka , N. Fukase , Antonio D'Amore, PhD , Y. Murata , P. Quinn , S. Luketich , K. Takayama , T. Matsumoto , J. H. Cummins , M. Kurosaka , R. Kuroda , W. R. Wagner , F. H. Fu , J. Huard
Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2020.10.037Progetto di ricerca
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Double Component Mandrel for Electrospun Stentless, Multi-leaflet Valve FabricationVinay Badhwar , Young Jae Chun , Antonio D'Amore, PhD , William R. Wagner
US patent issued in 09-28-2021, publication number: US-2021-129711-B1.
EU Issued patent 16756 4715, 03-02-2026, 02-14-2022.
Japanese patent issued in 10-10-2023, patent number: 7787131.
Licensed to Neoolife Inc. in 10-2020.
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Development of a semi-automated, bulk seeding device for large animal model implantation of tissue engineered vascular graftsE. M. Cunnane , K. L. Lorentz , L. Soletti , A. K. Ramaswamy , T. K. Chung , D. G. Haskett , S. K. Luketich , E. T. Tzeng , Antonio D'Amore, PhD , W. R. Wagner , J. S. Weinbaum , D. A. Vorp
Frontiers in Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2020.597847Progetto di ricerca
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In situ heart valve tissue engineering: Is scaffold structural biomimicry overrated?Petra Mela , Antonio D'Amore, PhD
Journal of American College of Cardiology Basic to Translational Science
https://doi.org/10.1016/j.jacbts.2020.11.009Progetto di ricerca
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Acute In Vivo Functional Assessment of a Biodegradable Stentless Elastomeric Tricuspid ValveGarrett N. Coyan , Lindemberg da Mota Silveira-Filho , Yasumoto Matsumura , Samuel K. Luketich , William Katz , Vinay Badhwar , William R. Wagner , Antonio D'Amore, PhD
Journal of Cardiovascular Translational Research
https://doi.org/10.1007/s12265-020-09960-zProgetto di ricerca
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Photo-oxidation crosslinked, glutaraldehyde crosslinked, or enzyme and hydrostatic pressure processed decellularized biomaterials for cardiovascular repair do not affect host response in a rat right ventricular outflow flow tract reconstruction (RVOT) model
Parnaz Boodagh †, Laura Modica De Mohac, PhD , Yasurani Hayashi , Danila Vella, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Taro Fujii , Emily Gorge , Garrett Coyan , Laubrie Soto Joan Dario, PhD , Gaetano Burriesci, PhD , William R. Wagner , Antonio D'Amore, PhD *
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(2):e35529 (2025)
https://doi.org/10.1002/jbm.b.35529Progetto di ricerca
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Tissue to Organ Level Evaluation of Heart Valve Scaffold Performance under Dynamic Loading ConditionsD. Pedersen , F. Madonia , C.Tompkins-Rhoades , Antonio D'Amore, PhD , W. R. Wagne
American Heart Association (AHA) 2019 Annual meeting November 16–18, Philadelphia PA, USA. Circulation 140 (Suppl. 1), A16249-A16249
https://www.ahajournals.org/doi/abs/10.1161/circ.140.suppl_1.16249Progetto di ricerca
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Biomimetic engineered chordae tendineae produced via novel mandrel-less electrospinningG. Spiaggia , Arianna Adamo, PhD , G. Coyan , W. R. Wagner , Antonio D'Amore, PhD
Annual Scientific Meeting of the Heart Valve Society, April 11-13, 2019, Sitges, Spain. Structural Heart
https://doi.org/10.1080/24748706.2019.1589331Progetto di ricerca
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Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarctionYasumoto Matsumura , Yang Zhu , Hongbin Jiang , Antonio D'Amore, PhD , Samuel K. Luketich , Verena Charwat , Tomo Yoshizumi , Hideyoshi Sato , Brenda Yang , Takafumi Uchibori , Kevin E. Healy , William R. Wagner
Biomaterials
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Evaluation of Microscopic Structure−Function Relationships of PEGylated Small Intestinal Submucosa Vascular Grafts for Arteriovenous ConnectionKaren T. Valencia-Rivero , Juan C. Cruz , Nicolle Wagner-Gutierrez , Antonio D'Amore, PhD , Maria C. Miranda , Rocío López , Albert Guerrero , William Wagner , Néstor Sandoval , Juan C. Briceño
ACS Applied Bio Materials
https://doi.org/10.1021/acsabm.9b00158Progetto di ricerca
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Blending Polymer Labile Elements at Differing Scales to Affect Degradation Profiles in Heart Valve ScaffoldsAntonio D'Amore, PhD , Samuel K. Luketich , Richard Hoff , Sang-Ho Ye , William R. Wagner
Biomacromolecules
https://doi.org/10.1021/acs.biomac.9b00189Progetto di ricerca
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In vivo functional assessment of a novel degradable metal and elastomeric scaffold-based tissue engineered heart valveGarrett N. Coyan , Antonio D'Amore, PhD , Yasumoto Matsumura , Drake D. Pedersen , Samuel K. Luketich , Vesselin Shanov , William E. Katz , Tirone E. David , William R. Wagner , Vinay Badhwar
The Journal of Thoracic and Cardiovascular Surgery
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Cytocompatibility and mechanical properties of surgical sealants for cardiovascular applicationsMark H. Murdock , Jordan T. Chang , Samuel K. Luketich , Drake Pedersen , George S. Hussey , Antonio D'Amore, PhD , Stephen F. Badylak
The Journal of Thoracic and Cardiovascular Surgery
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Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structureAntonio D'Amore, PhD , Samuel K. Luketich , Giuseppe M. Raffa , Salim Olia , Giorgio Menallo , Antonino Mazzola , Flavio D'Accardi , Tamir Grunberg , Xinzhu Gu , Michele Pilato , Marina V. Kameneva , Vinay Badhwar , William R. Wagner
Biomaterials
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Expandable percutaneous cannulaVinay Badhwar , Antonio D'Amore, PhD , Daniel McKeel , William R. Wagner
EU Issued patent 3579896, 06-02-2022, 02-14-2022
US Patent issued in 05-22-2025, publication number: US12280195B2
https://patents.google.com/patent/EP3579896B1/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22&page=1Progetto di ricerca
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Nitro-Oleic Acid (NO2-OA) Release Enhances Regional Angiogenesis in a Rat Abdominal Wall Defect ModelAntonio D'Amore, PhD , Marco Fazzari , Hong-Bin Jiang , Samuel K. Luketich , Michael E. Luketich , Richard Hoff , Daniel L. Jacobs , Xinzhu Gu , Stephen F. Badylak , Bruce A. Freeman , William R. Wagner
Tissue Engineering Part A
https://doi.org/10.1089/ten.tea.2017.0349Progetto di ricerca
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Hybrid scaffolds of Mg alloy mesh reinforced polymer/extracellular matrix composite for critical-sized calvarial defect reconstructionYingqi Chen , Sang-Ho Ye , Hideyoshi Sato , Yang Zhu , Vesselin Shanov , Tarannum Tiasha , Antonio D'Amore, PhD , Samuel Luketich , Guojiang Wan , William R. Wagner
Journal of Tissue Engineering and Regenerative Medicine
https://doi.org/10.1002/term.2668Progetto di ricerca
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An exploratory study on the preparation and evaluation of a “same-day” adipose stem cell–based tissue-engineered vascular graftDarren G. Haskett , Kamiel S. Saleh , Katherine L. Lorentz , Alexander D. Josowitz , Samuel K. Luketich , Justin S. Weinbaum , Lauren E. Kokai , Antonio D'Amore, PhD , Kacey G. Marra , J. Peter Rubin , William R. Wagner , David A. Vorp
The Journal of Thoracic and Cardiovascular Surgery
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Meso-scale topological cues influence extracellular matrix production in a large deformation, elastomeric scaffold modelAntonio D'Amore, PhD , Gabriele Nasello , Samuel K. Luketich , Dima Denisenko , Daniel L. Jacobs , Richard Hoff , Gregory Gibson , Alessandro Bruno , Manuela T. Raimondi , William R. Wagner
Soft Matter
https://doi.org/10.1039/C8SM01352GProgetto di ricerca
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Adipose derived stem cells enhance cardiac function preservation of a biodegradable cardiac patch and increase vascularization in rats with subacute myocardial infarctionN. Kashiyama , R. L Kormos , Y. Matsumura , S. Higuchi , L. M Silveira-Filho , G. Coyan , J. Hong Bin , Antonio D'Amore, PhD , W. R. Wagner
Circulation
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Decreased platelet deposition in SIS-based vascular grafts via covalent conjugation of RAFT polymersT. K. Valencia-Rivero , J. C. Cruz , J. C. Briceño , Antonio D'Amore, PhD , S-H Ye , J. Vande Geest , W. R Wagner
2018 IX International Seminar of Biomedical Engineering (SIB)
https://doi.org/10.1109/SIB.2018.8467727Progetto di ricerca
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Mandrel-less Electrospinning Processing Method and System, and Uses ThereforAntonio D'Amore, PhD , William R. Wagner
US Patent issued in 06-20-2023, publication number: US 11,680,341 B2
EU Issued patent 187721865, 12-30-2025
Licensed to Neoolife Inc. in 7-2025
https://patents.google.com/patent/US20200010979A1/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Progetto di ricerca
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A stentless biopolymer heart valve replacement capable of living tissue regenerationVinay Badhwar , Antonio D'Amore, PhD , Yasumoto Matsumura , William R. Wagner
US Patent issued in 01-13-2026, publication number: US12521235
Licensed to Neoolife Inc. in 10-2020.
https://patents.google.com/patent/US12521235B2/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Progetto di ricerca
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Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graftJeffrey T. Krawiec , Hans-Tsung Liao , LaiYee Lily Kwan , Antonio D'Amore, PhD , Justin S. Weinbaum , J Peter Rubin , William R Wagner , David A Vorp
Journal of Vascular Surgery
https://doi.org/10.1016/j.jvs.2016.09.034Progetto di ricerca
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Bi-layer polyurethane - extra cellular matrix scaffolds for improved ischemic ventricular wall remodeling
EU Issued patent 3347063, 30-10-2025
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Mechanical and microstructural analysis of a radially expandable vascular conduit for neonatal and pediatric cardiovascular surgeryAbigail E. Loneker , Samuel K. Luketich , Doug Bernstein , Arush Kalra , Alan W. Nugent , Antonio D'Amore, PhD , Denver M. Faulk
Journal of Biomedical Materials Research Part A
https://doi.org/10.1002/jbm.b.33874Progetto di ricerca
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Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graftJeffrey T. Krawiec , Han-Tsung Liao , LaiYee (Lily) Kwan , Antonio D'Amore, PhD , Justin S. Weinbaum , J. Peter Rubin , William R. Wagner , David A. Vorp
Journal of Vascular Surgery
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Journal Paper
Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversionKristen M. Stearns-Reider , Antonio D'Amore, PhD , Kevin Beezhold , Benjamin Rothrauff , Loredana Cavalli , William R. Wagner , David A. Vorp , Alkiviadis Tsamis , Sunita Shinde , Changqing Zhang , Aaron Barchowsky , Thomas A. Rando , Rocky S. Tuan , Fabrisia Ambrosio
Aging Cells
https://doi.org/10.1111/acel.12578Progetto di ricerca
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Journal Paper
Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat modelAntonio D'Amore, PhD , Tomo Yoshizumi , Samuel K. Luketich , Matthew T. Wolf , Xinzhu Gu , Marcello Cammarata , Richard Hoff , Stephen F. Badylak , William R. Wagner
Biomaterials
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Patent
Retrievable self-expanding non- thrombogenic low-profile percutaneous atrioventricular valve prosthesisVinay Badhwar , Young Jae Chun , Antonio D'Amore, PhD , David S. Schwartzman , William R. Wagner
US patent issued in 03-03-2026, publication number: US 12,564,492.
Licensed to Neoolife Inc. in 10-2020.
https://patents.google.com/patent/US10583004B2/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Progetto di ricerca
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Journal Paper
Large strain stimulation promotes extracellular matrix production and stiffness in an elastomeric scaffold modelAntonio D'Amore, PhD , Joao S. Soares , John A. Stella , Will Zhang , Nicholas J. Amoroso , John E. Mayer , William R. Wagner , Michael S. Sacks
Journal of the Mechanical Behavior of Biomedical Materials
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Journal Paper
In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk PopulationsJeffrey T. Krawiec , Justin S. Weinbaum , Han-Tsung Liao , Aneesh K. Ramaswamy , Dominic J. Pezzone , Alexander D. Josowitz , Antonio D'Amore, PhD , J. Peter Rubin , William R. Wagner , David A. Vorp
Tissue Engineering Part A
https://doi.org/10.1089/ten.tea.2015.0379Progetto di ricerca
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Journal Paper
Extracellular matrix fiber microarchitecture is region-specific in bicuspid aortic valve-associated ascending aortopathyAlkiviadis Tsamis , Julie A. Phillippi , Ryan G. Koch , Patrick G. Chan , Jeffrey T. Krawiec , Antonio D'Amore, PhD , Simon C. Watkins , William R. Wagner , David A. Vorp , Thomas G. Gleason
The Journal of Thoracic and Cardiovascular Surgery
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Journal Paper
Arsenic Promotes NF‐Κb‐Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell FunctionChangqing Zhang , Ricardo Ferrari , Kevin Beezhold , Kristen Stearns-Reider , Antonio D'Amore, PhD , Martin Haschak , Donna Stolz , Paul D. Robbins , Aaron Barchowsky , Fabrisia Ambrosio
Stem Cells
https://doi.org/10.1002/stem.2232Progetto di ricerca
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Journal Paper
Geometric characterization and simulation of planar layered elastomeric fibrous biomaterials
James B. Carleton , Antonio D'Amore, PhD , Kristen R. Feaver , Gregory J. Rodin , Michael S. Sacks
Acta Biomaterialia
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Journal Paper
Fabrication of elastomeric scaffolds with curvilinear fibrous structures for heart valve leaflet engineeringChristopher M. Hobson , Nicholas J. Amoroso , Rouzbeh Amini , Ethan Ungchusri , Yi Hong , Antonio D'Amore, PhD , Michael S. Sacks , William R. Wagner
Journal of Biomedical Materials Research Part A
https://doi.org/10.1002/jbm.a.35450Progetto di ricerca
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Journal Paper
Correlations between transmural mechanical and morphological properties in porcine thoracic descending aortaAli Hemmasizadeh , Alkiviadis Tsamis , Rabee Cheheltani , Soroush Assari , Antonio D'Amore, PhD , Michael Autieri , Mohammad F. Kiani , Nancy Pleshko , William R. Wagner , Simon C. Watkins , David Vorp , Kurosh Darvish
Journal of the Mechanical Behavior of Biomedical Materials
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Journal Paper
Positive effects of an extracellular matrix hydrogel on rat anterior cruciate ligament fibroblast proliferation and collagen mRNA expressionRui Liang , Guoguang Yang , Kwang E. Kim , Antonio D'Amore, PhD , Aimee N. Pickering , Cuiling Zhang , Savio L-Y. Woo
Journal of Orthopaedic Translation
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Journal Paper
Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parametersSalvatore Pasta , Julie A. Phillippi , Alkiviadis Tsamis , Antonio D'Amore, PhD , Giuseppe M. Raffa , Michele Pilato , Cesare Scardulla , Simon C. Watkins , William R. Wagner , Thomas G. Gleason , David A. Vorp
Medical Engineering & Physics
https://doi.org/10.1016/j.medengphy.2015.11.001Progetto di ricerca
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Journal Paper
Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarctionTomo Yoshizumi , Yang Zhu , Hongbin Jiang , Antonio D'Amore, PhD , Hirokazu Sakaguchi , Jason Tchao , Kimimasa Tobita , William R. Wagner
Biomaterials
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Journal Paper
Solubilized liver extracellular matrix maintains primary rat hepatocyte phenotype in-vitroAbigail E. Loneker , Denver M. Faulk , George S. Hussey , Antonio D'Amore, PhD , Stephen F. Badylak
Journal of Biomedical Material Research Part A
https://doi.org/10.1002/jbm.a.35636Progetto di ricerca
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Dissemination
Evaluating cells from liposuction aspirates for vascular tissue engineering
J. T. Krawiec , K. Bruce , A. Josowitz , L. Kokai , Antonio D'Amore, PhD , J. Weinbaum , W. Wagner , P. Rubin , D. Vorp
Angiogenesis
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Journal Paper
Systems level approach reveals the correlation of endoderm differentiation of mouse embryonic stem cells with specific microstructural cues of fibrin gelsKeith Task , Antonio D'Amore, PhD , Satish Singh , Joe Candiello , Maria Jaramillo , William R. Wagner , Prashant Kumta , Ipsita Banerjee
Journal of the Royal Society Interface
https://doi.org/10.1098/rsif.2014.0009Progetto di ricerca
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Journal Paper
A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopyRyan G. Koch , Alkiviadis Tsamis , Antonio D'Amore, PhD , William R. Wagner , Simon C. Watkins , Thomas G. Gleason , David A. Vorp
Journal of Biomechanics
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Journal Paper
A mechanistic model on the role of “radially-running” collagen fibers on dissection properties of human ascending thoracic aortaSiladitya Pal , Alkiviadis Tsamis , Salvatore Pasta , Antonio D'Amore, PhD , Thomas G. Gleason , David A. Vorp , Spandan Maiti
Journal of Biomechanics
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Journal Paper
The effect of detergents on the basement membrane complex of a biologic scaffold materialD.M. Faulk , C.A. Carruthers , H.J. Warner , C.R. Kramer , J.E. Reing , L. Zhang , Antonio D'Amore, PhD , S.F. Badylak
Acta Biomaterialia
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Journal Paper
Nonthrombogenic, Biodegradable Elastomeric Polyurethanes with Variable Sulfobetaine ContentSang-Ho Ye , Yi Hong , Venkat Shankarraman , Samuel K. Luketich , Antonio D'Amore, PhD , William R. Wagner
ACS Applied Materials & Interfaces
https://doi.org/10.1021/am506998sProgetto di ricerca
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Journal Paper
Preparation and characterization of a biologic scaffold from esophageal mucosaTimothy J. Keane , Ricardo Londono , Ryan M. Carey , Christopher A. Carruthers , Janet E. Reing , Christopher L. Dearth , Antonio D'Amore, PhD , Christopher J. Medberry , Stephen F. Badylak
Biomaterials
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Journal Paper
Fiber micro-architecture in the longitudinal-radial and circumferential-radial planes of ascending thoracic aortic aneurysm mediaAlkiviadis Tsamis , Julie A. Phillippi , Ryan G. Koch , Salvatore Pasta , Antonio D'Amore, PhD , Simon C. Watkins , William R. Wagner , Thomas G. Gleason , David A. Vorp
Journal of Biomechanics
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Journal Paper
Abdominal wall reconstruction by a regionally distinct biocomposite of extracellular matrix digest and a biodegradable elastomerKeisuke Takanari , Yi Hong , Ryotaro Hashizume , Alexander Huber , Nicholas J. Amoroso , Antonio D'Amore, PhD , Stephen F. Badylak , William R. Wagner
Journal of Tissue Engineering and Regenerative Medicine
https://doi.org/10.1002/term.1834Progetto di ricerca
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Dissemination
Collagen fiber architecture in the longitudinal-radial plane of ascending aorta is distinctly different among bicuspid aortic valve and tricuspid aortic valve patients with ascending aortic aneurysm
A. Tsamis , J.A. Phillippi , S. Pasta , Antonio D'Amore, PhD , S. Watkins , W. Wagner , D. Vorp , T. Gleason
Cardiovascular Pathology
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Journal Paper
From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterialsAntonio D'Amore, PhD , Nicholas Amoroso , Riccardo Gottardi, PhD , Christopher Hobson , Christopher Carruthers , Simon Watkins , William R. Wagner , Michael S. Sacks
Journal of the Mechanical Behavior of Biomedical Materials
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Book/Book Chapter
Biomechanics and Finite Element Analysis
Michael Sacks , Antonio D'Amore, PhD , Hobson Chistopher
Biomaterials Science: An Introduction to Materials in Medicine, 3rd ed., Chapter I.1.4 "Biomechanics and Finite Element Analysis." Eds. Ratner, Hoffman, Schoen & Lemons. Elsevier Publisher, 2012. ISBN 9780123746269
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Dissemination
Fiber distribution of ascending thoracic aortic aneurysms associated with valve morphologyS. Pasta , J. Philippi , Antonio D'Amore, PhD , W. R. Wagner , S. Watkins , T. Gleason , D. Vorp
Journal of Biomechanics
https://dx.doi.org/http://dx.doi.org/10.1016/S0021-9290(12)70125-2Progetto di ricerca
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Dissemination
Controlling micro-structure to enhance de novo extracellular matrix deposition in elastomeric scaffolds for cardiac tissue regeneration
Antonio D'Amore, PhD , J. Stella , R. Hoff , N. Amoroso , M. Sacks , W. R. Wagner
Journal of Tissue Engineering and Regenerative Medicine
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Dissemination
Extracellular Matrix Hydrogels Prepared from Porcine Dermis and Urinary Bladder: Structure, Mechanics and In Vivo Remodeling
M. Wolf , K. Daly , E. Brennan-Pierce , S. Johnson , C. Carruthers , Antonio D'Amore, PhD , S. Nagarkar , S. Velankar , S. Badylak
Glycobiology
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Journal Paper
Microstructural manipulation of electrospun scaffolds for specific bending stiffness for heart valve tissue engineeringNicholas J. Amoroso , Antonio D'Amore, PhD , Yi Hong , Christian P. Rivera , Michael S. Sacks , William R. Wagner
Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2012.08.002Progetto di ricerca
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Journal Paper
Effects of fabrication on the mechanics, microstructure and micromechanical environment of small intestinal submucosa scaffolds for vascular tissue engineeringDiana M. Sánchez-Palencia , Antonio D'Amore, PhD , Andrés González-Mancera , William R. Wagner , Juan C. Briceño
Journal of Biomechanics
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Dissemination
Unseeded Engineered Valve Leaflets Retain Function and Remodel After Implant in Sheep Right Pulmonary Outflow TractA. S Bayoumi , Antonio D'Amore, PhD , E. Aikawa , N. Amoroso , S. E New , A. Cubberley , P. Chen , K. Shapero , R.F Padera , F. J Schoen , W. R Wagner , M. S Sacks , J. E Mayer
CIRCULATION
https://dx.doi.org/http://circ.ahajournals.org/cgi/content/meeting_abstract/126/21_MeetingAbstracts/A19201Progetto di ricerca
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Journal Paper
Elastomeric Electrospun Polyurethane Scaffolds: The Interrelationship Between Fabrication Conditions, Fiber Topology, and Mechanical PropertiesNicholas J. Amoroso , Antonio D'Amore, PhD , Yi Hong , William R. Wagner , Michael S. Sacks
Advanced materials
https://doi.org/10.1002/adma.201003210Progetto di ricerca
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Book/Book Chapter
The mechanics of native and engineered cardiac soft tissues
Michael S. Sacks , S. Wognum , J. Stella , E. Joyce , Antonio D'Amore, PhD ,
Comprehensive Biomaterials, Page 27 of 42 Chapter 94 “The Mechanics of Native and Engineered Cardiac Soft Tissue”. Volume 3, 113-132. Elsevier Publisher, 2011. ISBN: 9780080553023
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Journal Paper
A hydrogel derived from decellularized dermal extracellular matrixMatthew T. Wolf , Kerry A. Daly , Ellen P. Brennan-Pierce , Scott A. Johnson , Christopher A. Carruthers , Antonio D'Amore, PhD , Shailesh P. Nagarkar , Sachin S. Velankar , Stephen F. Badylak
Biomaterials
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