Antonio D’Amore, Ph.D.
Group coordinator
adamore@fondazionerimed.com
Contatti:
Antonio D’Amore, PhD
GROUP LEADER IN TISSUE ENGINEERING
adamore@fondazionerimed.com
tissueengineering@fondazionerimed.com
c/o ATeN Center – University of Palermo
Viale delle Scienze Ed. 18/A – 90100 Palermo, ITALY
Facilities:
Collaborazioni:
- University of Palermo, Palermo, Italy
- Advanced Technologies Network Center (ATeN Center), Palermo, Italy
- McGowan Institute for Regenerative Medicine (MIRM), Pittsburgh, USA
- University of Pittsburgh Medical Center (UPMC), Pittsburgh, USA
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT-IRCCS), Palermo, Italy
- Universidad Abierta Interamericana (UAI), Buenos Aires, Argentina
- Neoolife, Pittsburgh, USA
- TELEA BioTech, Sandrigo, Italy
- Columbia University Irving Medical Center (CUIMC), New York, USA
- Technical University of Munich, (TUM), Munich, Germany
- University of California Irvine (UCI), Irvine, USA
- Eindhoven University of Technology, NetherlandPolitecnico di Torino, Italy
- Università di Cagliari, Italy
- Policlinico di Milano, Italy
- Campus biomedico, Rome, Italy
- Università Cattolica del Sacro Cuore, Roma, Italy
Description
Dr. D’Amore’s cardiovascular tissue engineering laboratory seeks to couple a mechanistic understanding of the relationship between scaffolds micro-structure, mechanics, and endogenous tissue growth with the development of novel biomaterials for tissue engineering strategies. The focus of our research is upon unmet clinical needs in cardiovascular diseases. The ongoing funded projects (NIH, ERC, industry sponsored) share an integrated in silico, in vitro, in vivo approach where three critical steps in biomimicry are implemented: I) Observe (quantify specific native tissue and organ features); II) Understand (elucidate mechanisms based on the observation made); III) Develop (duplicate the identified properties and mechanisms, fabricate tissue surrogate accordingly and assess its performance).
Aims
Can a mechanistic understanding of how biomaterials and native tissue micro-structure translates into a specific biological response as well as a nature inspired control over biomaterials structure – function lead to a better performing generation of cardiovascular tissue surrogates?”
The statement of our mission reflects our vision of science where basic and translational research are equally fundamental and symbiotic in advancing human knowledge and addressing unmet clinical needs.
The connection of this research question with the Ri.MED Center scientific identity is twofold and bidirectional:
Humans → Environment
The medical devices and cardiovascular tissue engineering strategies we develop aim to enhance human resilience to the threats of the environment which, in this case, are the broad spectrum of cardiovascular diseases.
Humans ←Environment
Our group combines tissue engineering with biomimicry, this paradigm requires operatively and philosophically to study and unfold the complexity of nature, to identify, and ultimately to replicate critical properties for a specific clinical application.
Focus
- Tissue-engineered heart valves
- Tissue-engineered vascular grafts
- Tissue-engineered cardiac patches
- Bioreactors for enhanced extracellular matrix elaboration
- Native/engineered tissue image-based structural and histopathological analysis
- Native/engineered tissue numerical models for mechanics and tissue growth
Expertise and resources
- Engineered tissue and biomaterials fabrication
- Physical, and chemical characterization of native and engineered tissues
- Qualitative and quantitative histological evaluation
- Tissue surrogate models for mechanobiology
- Numerical modeling of tissue function, growth and scaffold degradation
- In vivo characterization of engineered tissue in large and small animal models
- 23 people strong, 150 m2 + of fully equipped wet lab space with focus on material fabrication and characterization
Team
Elisa Lanzalaco
Ph.D. Student in Chemical, Environmental, Biomedical, Hydraulic, and Materials engineering
Enrica Romano
Ph.D. Student in Chemical, Environmental, Biomedical, Hydraulic, and Materials engineering
Projects
- Native/Engineered Tissue Image-Based structural and histopathology Analysis (NET-IBA)
- Bioreactors for Enhanced Extra Cellular Matrix elaboration (BE-ECM)
- Native/Engineered Tissue numerical models for Mechanics and Tissue Growth (NET-MTG)
- Tissue engineered cardic patch (TECP)
- Tissue Engineering Heart Valve (TEHV)
- Tissue Engineered Vascular Graft (TEVG)
Publications
Journal Paper
Photo-oxidation crosslinked, glutaraldehyde crosslinked, or enzyme and hydrostatic pressure processed decellularized biomaterials for cardiovascular repair do not affect host response in a rat right ventricular outflow flow tract reconstruction (RVOT) model
Parnaz Boodagh †, Laura Modica De Mohac, PhD , Yasurani Hayashi , Danila Vella, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Taro Fujii , Emily Gorge , Garrett Coyan , Laubrie Soto Joan Dario, PhD , Gaetano Burriesci, PhD , William R Wagner , Antonio D'Amore, Ph.D.
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(2):e35529, 2025.
https://doi.org/10.1002/jbm.b.35529Research project
Research group
Facilities
Journal Paper
Generation of Human 3D Airway Assembloids for Advanced ModelingIachini M.C. , A. Coglot , D. Tace , N. Elia , F. Rusconi , Federica Cosentino, PhD , G. Lopez , M. Crosti , T.D. Usal , E. Scarpa , Antonio D'Amore, Ph.D. , V. Miceli , L. Rosso , L. Lazzari
International Journal of Biological Sciences
https://doi.org/10.7150/ijbs.113920Journal Paper
Engineering a Human-Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune ModulationMattia Pasqua, PhD , Marianna Barbuto , M. Calligaris , Roberto di Gesù, PhD , D. Pagano , R. Busà , S. Grutadauria , Simone Dario Scilabra, PhD , Antonio D'Amore, Ph.D. , Maria Giovanna Francipane, Ph.D.
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202501660Journal Paper
Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery bandingY. Hayashi , S. Kim , T. Fujii , D.D. Pedersen , T. Ozeki , H. Jiang , Antonio D'Amore, Ph.D. , W.R. Wagner
Frontiers in Bioengineering and Biotechnology
Journal Paper
Intervening to preserve function in ischemic cardiomyopathy with a porous hydrogel and extracellular matrix composite in a rat myocardial infarction model.Y. Hayashi , T. Fujii , S. Kim , T. Ozeki , S. Badylak , Antonio D'Amore, Ph.D. , M. Mutsuga , W.R. Wagner
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202402757Journal Paper
In Vitro Evaluation of Biomaterials for Heart Valve Prosthesis: High Hydrostatic and Enzymatic Treatments as Alternative for Bio-Derived MaterialsDanila Vella, PhD †, Parnaz Boodagh , Laura Modica De Mohac, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Federica Scaglione , Sofia Dei Bardi , Giulia Polizzi , Garrett Coyan , William R. Wagner , Gaetano Burriesci, PhD , Antonio D'Amore, Ph.D. *
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(6): e35592, 2025.
https://doi.org/10.1002/jbm.b.35592Research project
Research group
Facilities
Journal Paper
Tissue formation and remodeling of acellular elastomeric scaffold in ovine single pulmonary leaflet replacement model.Z. Machaidze , Antonio D'Amore, Ph.D. , R. Freitas , A. J. Joyce , A. Bayoumi , K. Rich , D.W. Brown , E. Aikawa , W. R. Wagner , B. Rego , J. E. Mayer
Journal of Biomedical Materials Research: Part A
https://doi.org/10.1002/jbm.a.37622Journal Paper
Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironmentTian Zhu , Steven M Alves , Arianna Adamo, PhD , Xiaona Wen , Kevin C Corn , Anastasia Shostak , Shereena Johnson , Nicholas D Shaub , Shannon E Martello , Benjamin C Hacker , Antonio D'Amore, Ph.D. , Rizia Bardhan , Marjan Rafat
Biomaterials, 308, 2024, 122531
https://doi.org/10.1016/j.biomaterials.2024.122531Journal Paper
Influence of Polymer Stiffness and Geometric Design on Fluid Mechanics in Tissue Engineered Pulmonary Valve Scaffolds.D. Pedersen , S. Kim , Antonio D'Amore, Ph.D. , W. R. Wagner
Annals of Biomedical Engineering
https://doi.org/10.1007/s10439-023-03401-zJournal Paper
Effect of the apron in the mechanical characterisation of hyperelastic materials by means of biaxial testing: A new method to improve accuracySofia Di Leonardo, PhD †, Alessandra Monteleone, PhD , Patrizia Caruso , Hugo Meecham-Garcia , Giuseppe Pitarresi , Gaetano Burriesci, PhD *
Journal of The Mechanical Behavior of Biomedical Materials 150: 106291, 2024
https://doi.org/10.1016/j.jmbbm.2023.106291Research project
Research group
Facilities
Journal Paper
Open- source Image-based Tool to Experimentally Evaluate Blood Residence Time in Clinical DevicesG. Menallo , R. Miraglia , R. Gerasia , Federica Cosentino, PhD , Pietro Terranova, PhD , Marianna Barbuto , W. R. Wagner , Antonio D'Amore, Ph.D.
ASAIO
https://doi.org/10.1097/mat.0000000000002138Journal Paper
Redefining vascular repair: revealing cellular responses on PEUU—gelatin electrospun vascular grafts for endothelialization and immune responses on in vitro models M. A. Rodríguez Soto , A. Riverso-Cortes , I. Orjuela-Garzon , I Fernandez-Calderon , C. Rodriguez , N. Suarez Vargas , C. Ostos , C. Muñoz Camargo , J. C. Cruz, , S. Kim , Antonio D'Amore, Ph.D. , W. R. Wagner , J. C. Briceño ,
Frontiers in Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2024.1410863Journal Paper
A versatile 5-axis melt electrowriting platform for unprecedented design freedom of 3D fibrous scaffoldsPietro Terranova, PhD , K.M.A. Mueller , D. Biebl , Antonio D'Amore, Ph.D. , P. Mela ,
Additive Manufacturing
https://doi.org/10.1016/j.addma.2024.104431Journal Paper
Bioengineering an in situ ovary (ISO) for fertility preservationM. J. Buckenmeyer , M. Sukhwani , A. Iftikhar , A. L. Nolfi , Z. Xian , S. Dadi , Z. W. Case , S. R. Steimer , Antonio D'Amore, Ph.D. , K. E. Orwig , B. N. Brown.
Journal of Tissue Engineering
http://dx.doi.org/10.1177/20417314231197282Journal Paper
Cardiac valve scaffold design: Implications of material properties and geometric configuration on performance and mechanicsDrake D. Pedersen, Ph.D. , Seungil Kim , Antonio D'Amore, Ph.D. , William R. Wagner
Journal of the Mechanical Behavior of Biomedical Materials
https://doi.org/10.1016/j.jmbbm.2023.106043Research project
Research group
Facilities
Journal Paper
Bioengineering an in situ ovary (ISO) for fertility preservationMichael J. Buckenmeyer , Meena Sukhwani , Aimon Iftikhar , Alexis L. Nolfi , Ziyu Xian , Srujan Dadi , Zachary W. Case , Sarah R. Steimer , Antonio D'Amore, Ph.D. , Kyle E. Orwig , Bryan N. Brown
Journal of Tissue Engineering
http://dx.doi.org/10.1177/20417314231197282Journal Paper
Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modificationsM.A. Rodriguez-Soto , A.M. Aragón , N.A. Suarez , M. Ayala-Velásquez , G. Peralta-Peluffo , J.C. Cruz , C. Muñoz Camargo , S. Kim , Antonio D'Amore, Ph.D. , W.R. Wagner , J.C. Briceño
Frontiers Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2023.1257778Dissemination
Engineering Anti-platelet polymers for regenerative cardiovascular applicationsM.A. Rodriguez-Soto , A.M. Aragón , N.A. Suarez , M. Ayala-Velásquez , G. Peralta-Peluffo , J.C. Cruz , C. Muñoz Camargo , S. Kim , Antonio D'Amore, Ph.D. , W.R.Wagner , J.C. Briceño
ASAIO Journal
https://doi.org/10.1097/01.mat.0000943416.83743.94Dissemination
Comparative Assessment of Prosthetic Biomaterials for Cardiac ApplicationsDanila Vella, PhD †, Parnaz Boodagh †, Laura Modica De Mohac, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Federica Scaglione , William Wagner , Antonio D'Amore, Ph.D. , Gaetano Burriesci, PhD
Proceedings of the 9th World Congress on Electrical Engineering and Computer Systems and Sciences (EECSS’23), ICBES 137, 2023. DOI: 10.11159/icbes23.137
https://avestia.com/EECSS2023_Proceedings/files/paper/ICBES/ICBES_137.pdfResearch project
Research group
Facilities
Journal Paper
Creating and Transferring an Innervated, Vascularized Muscle Flap Made from an Elastic, Cellularized Tissue Construct Developed In SituHideyoshi Sato , Keishi Kohyama , Takafumi Uchibori , Keisuke Takanari , Johnny Huard , Stephen F Badylak , Antonio D'Amore, Ph.D. , William R. Wagner
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202301335Patent
Processing Method and Apparatus for Micro-Structured Rope-Like MaterialAntonio D'Amore, Ph.D. , Daniel McKeel , William R. Wagner
https://patents.google.com/patent/US20220259773A1/enJournal Paper
Blood Vessel Detection Algorithm For Tissue Engineering And Quantitative HistologyArianna Adamo, PhD , Alessandro Bruno , Giorgio Menallo , Maria Giovanna Francipane, Ph.D. , Marco Fazzari , Roberto Pirrone , Edoardo Ardizzone , William R Wagner , Antonio D'Amore
Annals of Biomedical Engineering, 50(4):387-400, 2022
https://link.springer.com/article/10.1007/s10439-022-02923-2Research project
Research group
Facilities
Journal Paper
Blood Vessel Detection Algorithm for Tissue Engineering and Quantitative HistologyArianna Adamo, PhD , A. Bruno , G. Menallo , Maria Giovanna Francipane, Ph.D. , M. Fazzari , E. Ardizzone , W.R. Wagner , Antonio D'Amore, Ph.D.
Annals of Biomedical Engineering
https://doi.org/10.1007/s10439-022-02923-2Journal Paper
Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of Irradiation in Driving a Pro-Tumor and Immunosuppressive Microenvironment
Zhu T , Alves SM , Arianna Adamo, PhD , Wen X , Corn KC , Shostak A , Johnson S , Shaub ND , Martello SE , Hacker BC , Antonio D'Amore, Ph.D. , Bardhan R , Rafat M
https://doi.org/10.1101/2022.05.16.492117Patent
Transatrial access for intracardiac therapyVinay Badhwar , Antonio D'Amore, Ph.D. , William R. Wagner
US patent issued in 06-29-2021, publication number: US-2021-11045218-A1.
https://patents.google.com/patent/US11045218B2/en?oq=11%2c045%2c218Journal Paper
A Cell-free Biodegradable Synthetic Artificial Ligament for the Reconstruction of Anterior Cruciate Ligament (ACL) in a Rat ModelY. Kawakami , K. Nonaka , N. Fukase , Antonio D'Amore, Ph.D. , Y. Murata , P. Quinn , S. Luketich , K. Takayama , T. Matsumoto , J. H. Cummins , M. Kurosaka , R. Kuroda , W. R. Wagner , F. H. Fu , J. Huard
Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2020.10.037Journal Paper
In situ heart valve tissue engineering: Is scaffold structural biomimicry overrated?Petra Mela , Antonio D'Amore, Ph.D.
Journal of American College of Cardiology Basic to Translational Science
https://doi.org/10.1016/j.jacbts.2020.11.009Journal Paper
Acute In Vivo Functional Assessment of a Biodegradable Stentless Elastomeric Tricuspid ValveGarrett N. Coyan , Lindemberg da Mota Silveira-Filho , Yasumoto Matsumura , Samuel K. Luketich , William Katz , Vinay Badhwar , William R. Wagner , Antonio D'Amore, Ph.D.
Journal of Cardiovascular Translational Research
https://doi.org/10.1007/s12265-020-09960-zJournal Paper
Development of a semi-automated, bulk seeding device for large animal model implantation of tissue engineered vascular graftsE. M. Cunnane , K. L. Lorentz , L. Soletti , A. K. Ramaswamy , T. K. Chung , D. G. Haskett , S. K. Luketich , E. T. Tzeng , Antonio D'Amore, Ph.D. , W. R. Wagner , J. S. Weinbaum , D. A. Vorp
Frontiers in Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2020.597847Journal Paper
Photo-oxidation crosslinked, glutaraldehyde crosslinked, or enzyme and hydrostatic pressure processed decellularized biomaterials for cardiovascular repair do not affect host response in a rat right ventricular outflow flow tract reconstruction (RVOT) model
Parnaz Boodagh †, Laura Modica De Mohac, PhD , Yasurani Hayashi , Danila Vella, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Taro Fujii , Emily Gorge , Garrett Coyan , Laubrie Soto Joan Dario, PhD , Gaetano Burriesci, PhD , William R. Wagner , Antonio D'Amore, Ph.D. *
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(2):e35529 (2025)
https://doi.org/10.1002/jbm.b.35529Research project
Research group
Facilities
Dissemination
Biomimetic engineered chordae tendineae produced via novel mandrel-less electrospinningG. Spiaggia , Arianna Adamo, PhD , G. Coyan , W. R. Wagner , Antonio D'Amore, Ph.D.
Annual Scientific Meeting of the Heart Valve Society, April 11-13, 2019, Sitges, Spain. Structural Heart
https://doi.org/10.1080/24748706.2019.1589331Journal Paper
Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarctionYasumoto Matsumura , Yang Zhu , Hongbin Jiang , Antonio D'Amore, Ph.D. , Samuel K. Luketich , Verena Charwat , Tomo Yoshizumi , Hideyoshi Sato , Brenda Yang , Takafumi Uchibori , Kevin E. Healy , William R. Wagner
Biomaterials
Journal Paper
Evaluation of Microscopic Structure−Function Relationships of PEGylated Small Intestinal Submucosa Vascular Grafts for Arteriovenous ConnectionKaren T. Valencia-Rivero , Juan C. Cruz , Nicolle Wagner-Gutierrez , Antonio D'Amore, Ph.D. , Maria C. Miranda , Rocío López , Albert Guerrero , William Wagner , Néstor Sandoval , Juan C. Briceño
ACS Applied Bio Materials
https://doi.org/10.1021/acsabm.9b00158Dissemination
Tissue to Organ Level Evaluation of Heart Valve Scaffold Performance under Dynamic Loading ConditionsD. Pedersen , F. Madonia , C.Tompkins-Rhoades , Antonio D'Amore, Ph.D. , W. R. Wagne
American Heart Association (AHA) 2019 Annual meeting November 16–18, Philadelphia PA, USA. Circulation 140 (Suppl. 1), A16249-A16249
https://www.ahajournals.org/doi/abs/10.1161/circ.140.suppl_1.16249Journal Paper
Blending Polymer Labile Elements at Differing Scales to Affect Degradation Profiles in Heart Valve ScaffoldsAntonio D'Amore, Ph.D. , Samuel K. Luketich , Richard Hoff , Sang-Ho Ye , William R. Wagner
Biomacromolecules
https://doi.org/10.1021/acs.biomac.9b00189Journal Paper
In vivo functional assessment of a novel degradable metal and elastomeric scaffold-based tissue engineered heart valveGarrett N. Coyan , Antonio D'Amore, Ph.D. , Yasumoto Matsumura , Drake D. Pedersen , Samuel K. Luketich , Vesselin Shanov , William E. Katz , Tirone E. David , William R. Wagner , Vinay Badhwar
The Journal of Thoracic and Cardiovascular Surgery
Journal Paper
Cytocompatibility and mechanical properties of surgical sealants for cardiovascular applicationsMark H. Murdock , Jordan T. Chang , Samuel K. Luketich , Drake Pedersen , George S. Hussey , Antonio D'Amore, Ph.D. , Stephen F. Badylak
The Journal of Thoracic and Cardiovascular Surgery
Journal Paper
Hybrid scaffolds of Mg alloy mesh reinforced polymer/extracellular matrix composite for critical-sized calvarial defect reconstructionYingqi Chen , Sang-Ho Ye , Hideyoshi Sato , Yang Zhu , Vesselin Shanov , Tarannum Tiasha , Antonio D'Amore, Ph.D. , Samuel Luketich , Guojiang Wan , William R. Wagner
Journal of Tissue Engineering and Regenerative Medicine
https://doi.org/10.1002/term.2668Journal Paper
An exploratory study on the preparation and evaluation of a “same-day” adipose stem cell–based tissue-engineered vascular graftDarren G. Haskett , Kamiel S. Saleh , Katherine L. Lorentz , Alexander D. Josowitz , Samuel K. Luketich , Justin S. Weinbaum , Lauren E. Kokai , Antonio D'Amore, Ph.D. , Kacey G. Marra , J. Peter Rubin , William R. Wagner , David A. Vorp
The Journal of Thoracic and Cardiovascular Surgery
Journal Paper
Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structureAntonio D'Amore, Ph.D. , Samuel K. Luketich , Giuseppe M. Raffa , Salim Olia , Giorgio Menallo , Antonino Mazzola , Flavio D'Accardi , Tamir Grunberg , Xinzhu Gu , Michele Pilato , Marina V. Kameneva , Vinay Badhwar , William R. Wagner
Biomaterials
Journal Paper
Nitro-Oleic Acid (NO2-OA) Release Enhances Regional Angiogenesis in a Rat Abdominal Wall Defect ModelAntonio D'Amore, Ph.D. , Marco Fazzari , Hong-Bin Jiang , Samuel K. Luketich , Michael E. Luketich , Richard Hoff , Daniel L. Jacobs , Xinzhu Gu , Stephen F. Badylak , Bruce A. Freeman , William R. Wagner
Tissue Engineering Part A
https://doi.org/10.1089/ten.tea.2017.0349Journal Paper
Meso-scale topological cues influence extracellular matrix production in a large deformation, elastomeric scaffold modelAntonio D'Amore, Ph.D. , Gabriele Nasello , Samuel K. Luketich , Dima Denisenko , Daniel L. Jacobs , Richard Hoff , Gregory Gibson , Alessandro Bruno , Manuela T. Raimondi , William R. Wagner
Soft Matter
https://doi.org/10.1039/C8SM01352GJournal Paper
Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structureAntonio D'Amore, Ph.D. , Samuel K Luketich , Giuseppe M Raffa , Salim Olia , Giorgio Menallo , Antonino Mazzola , Flavio D'Accardi , Tamir Grunberg , Xinzhu Gu , Michele Pilato , Marina V Kameneva , Vinay Badhwar , William R Wagner
Biomaterials
https://doi.org/10.1016/j.biomaterials.2017.10.011Patent
A stentless biopolymer heart valve replacement capable of living tissue regenerationVinay Badhwar , Antonio D'Amore, Ph.D. , Yasumoto Matsumura , William R. Wagner
US Patent issued in 01-13-2026, publication number: US12521235
Licensed to Neoolife Inc. in 10-2020.
https://patents.google.com/patent/US12521235B2/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Patent
Expandable percutaneous cannulaVinay Badhwar , Antonio D'Amore, Ph.D. , Daniel McKeel , William R. Wagner
EU Issued patent 3579896, 06-02-2022, 02-14-2022
US Patent issued in 05-22-2025, publication number: US12280195B2
https://patents.google.com/patent/EP3579896B1/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22&page=1Patent
Mandrel-less Electrospinning Processing Method and System, and Uses ThereforAntonio D'Amore, Ph.D. , William R. Wagner
US Patent issued in 06-20-2023, publication number: US 11,680,341 B2
EU Issued patent 187721865, 12-30-2025
Licensed to Neoolife Inc. in 7-2025
https://patents.google.com/patent/US20200010979A1/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Dissemination
Decreased platelet deposition in SIS-based vascular grafts via covalent conjugation of RAFT polymersT. K. Valencia-Rivero , J. C. Cruz , J. C. Briceño , Antonio D'Amore, Ph.D. , S-H Ye , J. Vande Geest , W. R Wagner
2018 IX International Seminar of Biomedical Engineering (SIB)
https://doi.org/10.1109/SIB.2018.8467727Journal Paper
Adipose derived stem cells enhance cardiac function preservation of a biodegradable cardiac patch and increase vascularization in rats with subacute myocardial infarctionN. Kashiyama , R. L Kormos , Y. Matsumura , S. Higuchi , L. M Silveira-Filho , G. Coyan , J. Hong Bin , Antonio D'Amore, Ph.D. , W. R. Wagner
Circulation
Patent
Bi-layer polyurethane - extra cellular matrix scaffolds for improved ischemic ventricular wall remodeling
EU Issued patent 3347063, 30-10-2025
Journal Paper
Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graft
Jeffrey T. Krawiec , Hans-Tsung Liao , LaiYee Lily Kwan , Antonio D'Amore, Ph.D. , Justin S. Weinbaum , J Peter Rubin , William R Wagner , David A Vorp
https://doi.org/10.1016/j.jvs.2016.09.034Journal Paper
Mechanical and microstructural analysis of a radially expandable vascular conduit for neonatal and pediatric cardiovascular surgeryAbigail E. Loneker , Samuel K. Luketich , Doug Bernstein , Arush Kalra , Alan W. Nugent , Antonio D'Amore, Ph.D. , Denver M. Faulk
Journal of Biomedical Materials Research Part A
https://doi.org/10.1002/jbm.b.33874Journal Paper
Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graftJeffrey T. Krawiec , Han-Tsung Liao , LaiYee (Lily) Kwan , Antonio D'Amore, Ph.D. , Justin S. Weinbaum , J. Peter Rubin , William R. Wagner , David A. Vorp
Journal of Vascular Surgery
Journal Paper
Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversionKristen M. Stearns-Reider , Antonio D'Amore, Ph.D. , Kevin Beezhold , Benjamin Rothrauff , Loredana Cavalli , William R. Wagner , David A. Vorp , Alkiviadis Tsamis , Sunita Shinde , Changqing Zhang , Aaron Barchowsky , Thomas A. Rando , Rocky S. Tuan , Fabrisia Ambrosio
Aging Cells
https://doi.org/10.1111/acel.12578Patent
Retrievable self-expanding non- thrombogenic low-profile percutaneous atrioventricular valve prosthesisVinay Badhwar , Young Jae Chun , Antonio D'Amore, Ph.D. , David S. Schwartzman , William R. Wagner
US patent issued in 03-03-2026, publication number: US 12,564,492.
Licensed to Neoolife Inc. in 10-2020.
https://patents.google.com/patent/US10583004B2/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Journal Paper
Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat modelAntonio D'Amore, Ph.D. , Tomo Yoshizumi , Samuel K. Luketich , Matthew T. Wolf , Xinzhu Gu , Marcello Cammarata , Richard Hoff , Stephen F. Badylak , William R. Wagner
Biomaterials
Journal Paper
Large strain stimulation promotes extracellular matrix production and stiffness in an elastomeric scaffold modelAntonio D'Amore, Ph.D. , Joao S. Soares , John A. Stella , Will Zhang , Nicholas J. Amoroso , John E. Mayer , William R. Wagner , Michael S. Sacks
Journal of the Mechanical Behavior of Biomedical Materials
Journal Paper
In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk PopulationsJeffrey T. Krawiec , Justin S. Weinbaum , Han-Tsung Liao , Aneesh K. Ramaswamy , Dominic J. Pezzone , Alexander D. Josowitz , Antonio D'Amore, Ph.D. , J. Peter Rubin , William R. Wagner , David A. Vorp
Tissue Engineering Part A
https://doi.org/10.1089/ten.tea.2015.0379Journal Paper
Extracellular matrix fiber microarchitecture is region-specific in bicuspid aortic valve-associated ascending aortopathyAlkiviadis Tsamis , Julie A. Phillippi , Ryan G. Koch , Patrick G. Chan , Jeffrey T. Krawiec , Antonio D'Amore, Ph.D. , Simon C. Watkins , William R. Wagner , David A. Vorp , Thomas G. Gleason
The Journal of Thoracic and Cardiovascular Surgery
Journal Paper
Arsenic Promotes NF‐Κb‐Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell FunctionChangqing Zhang , Ricardo Ferrari , Kevin Beezhold , Kristen Stearns-Reider , Antonio D'Amore, Ph.D. , Martin Haschak , Donna Stolz , Paul D. Robbins , Aaron Barchowsky , Fabrisia Ambrosio
Stem Cells
https://doi.org/10.1002/stem.2232Journal Paper
Geometric characterization and simulation of planar layered elastomeric fibrous biomaterials
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Evaluating cells from liposuction aspirates for vascular tissue engineering
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Collagen fiber architecture in the longitudinal-radial plane of ascending aorta is distinctly different among bicuspid aortic valve and tricuspid aortic valve patients with ascending aortic aneurysm
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Fiber distribution of ascending thoracic aortic aneurysms associated with valve morphologyS. Pasta , J. Philippi , Antonio D'Amore, Ph.D. , W. R. Wagner , S. Watkins , T. Gleason , D. Vorp
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Extracellular Matrix Hydrogels Prepared from Porcine Dermis and Urinary Bladder: Structure, Mechanics and In Vivo Remodeling
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Unseeded Engineered Valve Leaflets Retain Function and Remodel After Implant in Sheep Right Pulmonary Outflow TractA. S Bayoumi , Antonio D'Amore, Ph.D. , E. Aikawa , N. Amoroso , S. E New , A. Cubberley , P. Chen , K. Shapero , R.F Padera , F. J Schoen , W. R Wagner , M. S Sacks , J. E Mayer
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