Piattaforma di Ingegneria Tissutale
Description
La piattaforma di ingegneria dei tessuti è impegnata su due fronti integrati della ricerca traslazionale: la ricerca di base e la ricerca applicata, in particolare in ambito cardiovascolare. Questa piattaforma consente la caratterizzazione meccanica e strutturale dei tessuti nativi e bioingegnerizzati e lo studio in vitro ed in vivo dello sviluppo di tessuto de novo. Inoltre, offre modelli strutturali deterministici per la crescita e la rigenerazione di tessuto e software customizzati per la caratterizzazione strutturale dei tessuti e per lo studio quantitativo di sezioni istologiche. Da un punto di vista traslazionale, la piattaforma di ingegneria dei tessuti si focalizza sulle applicazioni cliniche nel contesto delle malattie cardiovascolari, ponendo maggiore enfasi sullo sviluppo di medical device, sul loro posizionamento e sullo studio di meccanismi minimamente invasivi di deployment. In particolare, la piattaforma è focalizzata sullo sviluppo di cardiac patch, valvole cardiache ingegnerizzate, vascular graft e chordae tendineae bioingegnerizzate. I nuovi laboratori di ingegneria tissutale sono dotati di sistemi di ultima generazione e consta-no di due macro unità: la prima di biofabbricazione, la cui strumentazione include una piattaforma di bioprinting basata su un braccio robotizzato a sei gradi di libertà, strumenti per elettrofilatura ed elettrodeposizione, ed una di caratterizzazione dei materiali e costrutti ingegnerizzati che include macchinari per le prove meccaniche, per la caratterizzazione istologica e della micro e macro struttura.
Expertise
- Sviluppo di dispositivi cardiovascolari come cardiac patch, vascular graft e valvole cardiache;
- Sintesi di polimeri con ampio grado di degradazione per lo sviluppo di dispositivi medici;
- Decellularizzazione di organi e tessuti;
- Caratterizzazione strutturale ed istologica di tessuti nativi ed ingegnerizzati;
- Sviluppo e prototipazione di sistemi per il posizionamento ed impianto in modalità minimamente invasiva dei dispositivi medici;
- Modellazione dei fenomeni che regolano la crescita e la rigenerazione del tessuto.
Facilities & Equipment
ATTREZZATURE TECNOLOGICHE
- Modelli numerici predittivi per la crescita e la rigenerazione del tessuto;
- Software per analisi quantitativa di sezioni istologiche;
- Software per la generazione di reti fibrose stocasticamente generate;
- Metodi innovativi di analisi morfologica di materiali micro e nano-strutturati;
- Sviluppo ed ottimizzazione di valvole cardiache ingegnerizzate tramite l’uso di un braccio robotico a sei gradi di libertà;
- Apparati per elettrodeposizione con e senza mandrino;
- Strumentazione per la caratterizzazione meccanica dei dispositivi ingegnerizzati in seno ai progetti TECP, TEHV e TEVG.
Contacts:
adamore@fondazionerimed.com
Collaboration:
- University of Pittsburgh (PITT), Pittsburgh, USA
- University of Pittsburgh Medical Center (UPMC), Pittsburgh (PA), USA
- Policlinico di Milano, Milano, Italy
- Advances Solutions Life Sciences (ASLS) Inc. – Louisville (KY), USA
- IRCCS ISMETT, Palermo, Italy
- ATeN Center, University of Palermo
- Telea Biotech – Tissue Engineering Biomedical Technologies, Italy
- JOMDD, Tokyo, Japan
- Columbia University Irving Medical Center (CUIMC), New York (NY), USA
Hardware
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Progetti attivi
Publications
Journal Paper
Photo-oxidation crosslinked, glutaraldehyde crosslinked, or enzyme and hydrostatic pressure processed decellularized biomaterials for cardiovascular repair do not affect host response in a rat right ventricular outflow flow tract reconstruction (RVOT) model
Parnaz Boodagh †, Laura Modica De Mohac, PhD , Yasurani Hayashi , Danila Vella, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Taro Fujii , Emily Gorge , Garrett Coyan , Laubrie Soto Joan Dario, PhD , Gaetano Burriesci, PhD , William R Wagner , Antonio D'Amore, Ph.D.
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(2):e35529, 2025.
https://doi.org/10.1002/jbm.b.35529Research project
Research group
Facilities
Journal Paper
In Vitro Evaluation of Biomaterials for Heart Valve Prosthesis: High Hydrostatic and Enzymatic Treatments as Alternative for Bio-Derived MaterialsDanila Vella, PhD †, Parnaz Boodagh , Laura Modica De Mohac, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Federica Scaglione , Sofia Dei Bardi , Giulia Polizzi , Garrett Coyan , William R. Wagner , Gaetano Burriesci, PhD , Antonio D'Amore, Ph.D. *
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(6): e35592, 2025.
https://doi.org/10.1002/jbm.b.35592Research project
Research group
Facilities
Journal Paper
Intervening to preserve function in ischemic cardiomyopathy with a porous hydrogel and extracellular matrix composite in a rat myocardial infarction model.Y. Hayashi , T. Fujii , S. Kim , T. Ozeki , S. Badylak , Antonio D'Amore, Ph.D. , M. Mutsuga , W.R. Wagner
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202402757Journal Paper
Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery bandingY. Hayashi , S. Kim , T. Fujii , D.D. Pedersen , T. Ozeki , H. Jiang , Antonio D'Amore, Ph.D. , W.R. Wagner
Frontiers in Bioengineering and Biotechnology
Journal Paper
Engineering a Human-Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune ModulationMattia Pasqua, PhD , Marianna Barbuto , M. Calligaris , Roberto di Gesù, PhD , D. Pagano , R. Busà , S. Grutadauria , Simone Dario Scilabra, PhD , Antonio D'Amore, Ph.D. , Maria Giovanna Francipane, Ph.D.
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202501660Journal Paper
Generation of Human 3D Airway Assembloids for Advanced ModelingIachini M.C. , A. Coglot , D. Tace , N. Elia , F. Rusconi , Federica Cosentino, PhD , G. Lopez , M. Crosti , T.D. Usal , E. Scarpa , Antonio D'Amore, Ph.D. , V. Miceli , L. Rosso , L. Lazzari
International Journal of Biological Sciences
https://doi.org/10.7150/ijbs.113920Journal Paper
Bioengineering an in situ ovary (ISO) for fertility preservationM. J. Buckenmeyer , M. Sukhwani , A. Iftikhar , A. L. Nolfi , Z. Xian , S. Dadi , Z. W. Case , S. R. Steimer , Antonio D'Amore, Ph.D. , K. E. Orwig , B. N. Brown.
Journal of Tissue Engineering
http://dx.doi.org/10.1177/20417314231197282Journal Paper
Tissue formation and remodeling of acellular elastomeric scaffold in ovine single pulmonary leaflet replacement model.Z. Machaidze , Antonio D'Amore, Ph.D. , R. Freitas , A. J. Joyce , A. Bayoumi , K. Rich , D.W. Brown , E. Aikawa , W. R. Wagner , B. Rego , J. E. Mayer
Journal of Biomedical Materials Research: Part A
https://doi.org/10.1002/jbm.a.37622Journal Paper
Influence of Polymer Stiffness and Geometric Design on Fluid Mechanics in Tissue Engineered Pulmonary Valve Scaffolds.D. Pedersen , S. Kim , Antonio D'Amore, Ph.D. , W. R. Wagner
Annals of Biomedical Engineering
https://doi.org/10.1007/s10439-023-03401-zJournal Paper
Open- source Image-based Tool to Experimentally Evaluate Blood Residence Time in Clinical DevicesG. Menallo , R. Miraglia , R. Gerasia , Federica Cosentino, PhD , Pietro Terranova, PhD , Marianna Barbuto , W. R. Wagner , Antonio D'Amore, Ph.D.
ASAIO
https://doi.org/10.1097/mat.0000000000002138Journal Paper
Redefining vascular repair: revealing cellular responses on PEUU—gelatin electrospun vascular grafts for endothelialization and immune responses on in vitro models M. A. Rodríguez Soto , A. Riverso-Cortes , I. Orjuela-Garzon , I Fernandez-Calderon , C. Rodriguez , N. Suarez Vargas , C. Ostos , C. Muñoz Camargo , J. C. Cruz, , S. Kim , Antonio D'Amore, Ph.D. , W. R. Wagner , J. C. Briceño ,
Frontiers in Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2024.1410863Journal Paper
A versatile 5-axis melt electrowriting platform for unprecedented design freedom of 3D fibrous scaffoldsPietro Terranova, PhD , K.M.A. Mueller , D. Biebl , Antonio D'Amore, Ph.D. , P. Mela ,
Additive Manufacturing
https://doi.org/10.1016/j.addma.2024.104431Journal Paper
Cardiac valve scaffold design: Implications of material properties and geometric configuration on performance and mechanicsDrake D. Pedersen, Ph.D. , Seungil Kim , Antonio D'Amore, Ph.D. , William R. Wagner
Journal of the Mechanical Behavior of Biomedical Materials
https://doi.org/10.1016/j.jmbbm.2023.106043Research project
Research group
Facilities
Dissemination
Engineering Anti-platelet polymers for regenerative cardiovascular applicationsM.A. Rodriguez-Soto , A.M. Aragón , N.A. Suarez , M. Ayala-Velásquez , G. Peralta-Peluffo , J.C. Cruz , C. Muñoz Camargo , S. Kim , Antonio D'Amore, Ph.D. , W.R.Wagner , J.C. Briceño
ASAIO Journal
https://doi.org/10.1097/01.mat.0000943416.83743.94Journal Paper
Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modificationsM.A. Rodriguez-Soto , A.M. Aragón , N.A. Suarez , M. Ayala-Velásquez , G. Peralta-Peluffo , J.C. Cruz , C. Muñoz Camargo , S. Kim , Antonio D'Amore, Ph.D. , W.R. Wagner , J.C. Briceño
Frontiers Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2023.1257778Journal Paper
Bioengineering an in situ ovary (ISO) for fertility preservationMichael J. Buckenmeyer , Meena Sukhwani , Aimon Iftikhar , Alexis L. Nolfi , Ziyu Xian , Srujan Dadi , Zachary W. Case , Sarah R. Steimer , Antonio D'Amore, Ph.D. , Kyle E. Orwig , Bryan N. Brown
Journal of Tissue Engineering
http://dx.doi.org/10.1177/20417314231197282Dissemination
Comparative Assessment of Prosthetic Biomaterials for Cardiac ApplicationsDanila Vella, PhD †, Parnaz Boodagh †, Laura Modica De Mohac, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Federica Scaglione , William Wagner , Antonio D'Amore, Ph.D. , Gaetano Burriesci, PhD
Proceedings of the 9th World Congress on Electrical Engineering and Computer Systems and Sciences (EECSS’23), ICBES 137, 2023. DOI: 10.11159/icbes23.137
https://avestia.com/EECSS2023_Proceedings/files/paper/ICBES/ICBES_137.pdfResearch project
Research group
Facilities
Journal Paper
Creating and Transferring an Innervated, Vascularized Muscle Flap Made from an Elastic, Cellularized Tissue Construct Developed In SituHideyoshi Sato , Keishi Kohyama , Takafumi Uchibori , Keisuke Takanari , Johnny Huard , Stephen F Badylak , Antonio D'Amore, Ph.D. , William R. Wagner
Advanced Healthcare Materials
https://doi.org/10.1002/adhm.202301335Journal Paper
Blood Vessel Detection Algorithm For Tissue Engineering And Quantitative HistologyArianna Adamo, PhD , Alessandro Bruno , Giorgio Menallo , Maria Giovanna Francipane, Ph.D. , Marco Fazzari , Roberto Pirrone , Edoardo Ardizzone , William R Wagner , Antonio D'Amore
Annals of Biomedical Engineering, 50(4):387-400, 2022
https://link.springer.com/article/10.1007/s10439-022-02923-2Research project
Research group
Facilities
Patent
Processing Method and Apparatus for Micro-Structured Rope-Like MaterialAntonio D'Amore, Ph.D. , Daniel McKeel , William R. Wagner
https://patents.google.com/patent/US20220259773A1/enJournal Paper
Blood Vessel Detection Algorithm for Tissue Engineering and Quantitative HistologyArianna Adamo, PhD , A. Bruno , G. Menallo , Maria Giovanna Francipane, Ph.D. , M. Fazzari , E. Ardizzone , W.R. Wagner , Antonio D'Amore, Ph.D.
Annals of Biomedical Engineering
https://doi.org/10.1007/s10439-022-02923-2Patent
Transatrial access for intracardiac therapyVinay Badhwar , Antonio D'Amore, Ph.D. , William R. Wagner
US patent issued in 06-29-2021, publication number: US-2021-11045218-A1.
https://patents.google.com/patent/US11045218B2/en?oq=11%2c045%2c218Journal Paper
A Cell-free Biodegradable Synthetic Artificial Ligament for the Reconstruction of Anterior Cruciate Ligament (ACL) in a Rat ModelY. Kawakami , K. Nonaka , N. Fukase , Antonio D'Amore, Ph.D. , Y. Murata , P. Quinn , S. Luketich , K. Takayama , T. Matsumoto , J. H. Cummins , M. Kurosaka , R. Kuroda , W. R. Wagner , F. H. Fu , J. Huard
Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2020.10.037Journal Paper
Photo-oxidation crosslinked, glutaraldehyde crosslinked, or enzyme and hydrostatic pressure processed decellularized biomaterials for cardiovascular repair do not affect host response in a rat right ventricular outflow flow tract reconstruction (RVOT) model
Parnaz Boodagh †, Laura Modica De Mohac, PhD , Yasurani Hayashi , Danila Vella, PhD , Sang-Ho Ye , Federica Cosentino, PhD , Taro Fujii , Emily Gorge , Garrett Coyan , Laubrie Soto Joan Dario, PhD , Gaetano Burriesci, PhD , William R. Wagner , Antonio D'Amore, Ph.D. *
Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 113(2):e35529 (2025)
https://doi.org/10.1002/jbm.b.35529Research project
Research group
Facilities
Journal Paper
Development of a semi-automated, bulk seeding device for large animal model implantation of tissue engineered vascular graftsE. M. Cunnane , K. L. Lorentz , L. Soletti , A. K. Ramaswamy , T. K. Chung , D. G. Haskett , S. K. Luketich , E. T. Tzeng , Antonio D'Amore, Ph.D. , W. R. Wagner , J. S. Weinbaum , D. A. Vorp
Frontiers in Bioengineering and Biotechnology
https://doi.org/10.3389/fbioe.2020.597847Journal Paper
In situ heart valve tissue engineering: Is scaffold structural biomimicry overrated?Petra Mela , Antonio D'Amore, Ph.D.
Journal of American College of Cardiology Basic to Translational Science
https://doi.org/10.1016/j.jacbts.2020.11.009Journal Paper
Acute In Vivo Functional Assessment of a Biodegradable Stentless Elastomeric Tricuspid ValveGarrett N. Coyan , Lindemberg da Mota Silveira-Filho , Yasumoto Matsumura , Samuel K. Luketich , William Katz , Vinay Badhwar , William R. Wagner , Antonio D'Amore, Ph.D.
Journal of Cardiovascular Translational Research
https://doi.org/10.1007/s12265-020-09960-zDissemination
Biomimetic engineered chordae tendineae produced via novel mandrel-less electrospinningG. Spiaggia , Arianna Adamo, PhD , G. Coyan , W. R. Wagner , Antonio D'Amore, Ph.D.
Annual Scientific Meeting of the Heart Valve Society, April 11-13, 2019, Sitges, Spain. Structural Heart
https://doi.org/10.1080/24748706.2019.1589331Journal Paper
Cytocompatibility and mechanical properties of surgical sealants for cardiovascular applicationsMark H. Murdock , Jordan T. Chang , Samuel K. Luketich , Drake Pedersen , George S. Hussey , Antonio D'Amore, Ph.D. , Stephen F. Badylak
The Journal of Thoracic and Cardiovascular Surgery
Journal Paper
In vivo functional assessment of a novel degradable metal and elastomeric scaffold-based tissue engineered heart valveGarrett N. Coyan , Antonio D'Amore, Ph.D. , Yasumoto Matsumura , Drake D. Pedersen , Samuel K. Luketich , Vesselin Shanov , William E. Katz , Tirone E. David , William R. Wagner , Vinay Badhwar
The Journal of Thoracic and Cardiovascular Surgery
Journal Paper
Blending Polymer Labile Elements at Differing Scales to Affect Degradation Profiles in Heart Valve ScaffoldsAntonio D'Amore, Ph.D. , Samuel K. Luketich , Richard Hoff , Sang-Ho Ye , William R. Wagner
Biomacromolecules
https://doi.org/10.1021/acs.biomac.9b00189Journal Paper
Evaluation of Microscopic Structure−Function Relationships of PEGylated Small Intestinal Submucosa Vascular Grafts for Arteriovenous ConnectionKaren T. Valencia-Rivero , Juan C. Cruz , Nicolle Wagner-Gutierrez , Antonio D'Amore, Ph.D. , Maria C. Miranda , Rocío López , Albert Guerrero , William Wagner , Néstor Sandoval , Juan C. Briceño
ACS Applied Bio Materials
https://doi.org/10.1021/acsabm.9b00158Journal Paper
Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarctionYasumoto Matsumura , Yang Zhu , Hongbin Jiang , Antonio D'Amore, Ph.D. , Samuel K. Luketich , Verena Charwat , Tomo Yoshizumi , Hideyoshi Sato , Brenda Yang , Takafumi Uchibori , Kevin E. Healy , William R. Wagner
Biomaterials
Dissemination
Tissue to Organ Level Evaluation of Heart Valve Scaffold Performance under Dynamic Loading ConditionsD. Pedersen , F. Madonia , C.Tompkins-Rhoades , Antonio D'Amore, Ph.D. , W. R. Wagne
American Heart Association (AHA) 2019 Annual meeting November 16–18, Philadelphia PA, USA. Circulation 140 (Suppl. 1), A16249-A16249
https://www.ahajournals.org/doi/abs/10.1161/circ.140.suppl_1.16249Patent
A stentless biopolymer heart valve replacement capable of living tissue regenerationVinay Badhwar , Antonio D'Amore, Ph.D. , Yasumoto Matsumura , William R. Wagner
US Patent issued in 01-13-2026, publication number: US12521235
Licensed to Neoolife Inc. in 10-2020.
https://patents.google.com/patent/US12521235B2/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Patent
Expandable percutaneous cannulaVinay Badhwar , Antonio D'Amore, Ph.D. , Daniel McKeel , William R. Wagner
EU Issued patent 3579896, 06-02-2022, 02-14-2022
US Patent issued in 05-22-2025, publication number: US12280195B2
https://patents.google.com/patent/EP3579896B1/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22&page=1Patent
Mandrel-less Electrospinning Processing Method and System, and Uses ThereforAntonio D'Amore, Ph.D. , William R. Wagner
US Patent issued in 06-20-2023, publication number: US 11,680,341 B2
EU Issued patent 187721865, 12-30-2025
Licensed to Neoolife Inc. in 7-2025
https://patents.google.com/patent/US20200010979A1/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Journal Paper
Meso-scale topological cues influence extracellular matrix production in a large deformation, elastomeric scaffold modelAntonio D'Amore, Ph.D. , Gabriele Nasello , Samuel K. Luketich , Dima Denisenko , Daniel L. Jacobs , Richard Hoff , Gregory Gibson , Alessandro Bruno , Manuela T. Raimondi , William R. Wagner
Soft Matter
https://doi.org/10.1039/C8SM01352GDissemination
Decreased platelet deposition in SIS-based vascular grafts via covalent conjugation of RAFT polymersT. K. Valencia-Rivero , J. C. Cruz , J. C. Briceño , Antonio D'Amore, Ph.D. , S-H Ye , J. Vande Geest , W. R Wagner
2018 IX International Seminar of Biomedical Engineering (SIB)
https://doi.org/10.1109/SIB.2018.8467727Journal Paper
Adipose derived stem cells enhance cardiac function preservation of a biodegradable cardiac patch and increase vascularization in rats with subacute myocardial infarctionN. Kashiyama , R. L Kormos , Y. Matsumura , S. Higuchi , L. M Silveira-Filho , G. Coyan , J. Hong Bin , Antonio D'Amore, Ph.D. , W. R. Wagner
Circulation
Journal Paper
Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structureAntonio D'Amore, Ph.D. , Samuel K Luketich , Giuseppe M Raffa , Salim Olia , Giorgio Menallo , Antonino Mazzola , Flavio D'Accardi , Tamir Grunberg , Xinzhu Gu , Michele Pilato , Marina V Kameneva , Vinay Badhwar , William R Wagner
Biomaterials
https://doi.org/10.1016/j.biomaterials.2017.10.011Journal Paper
An exploratory study on the preparation and evaluation of a “same-day” adipose stem cell–based tissue-engineered vascular graftDarren G. Haskett , Kamiel S. Saleh , Katherine L. Lorentz , Alexander D. Josowitz , Samuel K. Luketich , Justin S. Weinbaum , Lauren E. Kokai , Antonio D'Amore, Ph.D. , Kacey G. Marra , J. Peter Rubin , William R. Wagner , David A. Vorp
The Journal of Thoracic and Cardiovascular Surgery
Journal Paper
Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structureAntonio D'Amore, Ph.D. , Samuel K. Luketich , Giuseppe M. Raffa , Salim Olia , Giorgio Menallo , Antonino Mazzola , Flavio D'Accardi , Tamir Grunberg , Xinzhu Gu , Michele Pilato , Marina V. Kameneva , Vinay Badhwar , William R. Wagner
Biomaterials
Journal Paper
Nitro-Oleic Acid (NO2-OA) Release Enhances Regional Angiogenesis in a Rat Abdominal Wall Defect ModelAntonio D'Amore, Ph.D. , Marco Fazzari , Hong-Bin Jiang , Samuel K. Luketich , Michael E. Luketich , Richard Hoff , Daniel L. Jacobs , Xinzhu Gu , Stephen F. Badylak , Bruce A. Freeman , William R. Wagner
Tissue Engineering Part A
https://doi.org/10.1089/ten.tea.2017.0349Journal Paper
Hybrid scaffolds of Mg alloy mesh reinforced polymer/extracellular matrix composite for critical-sized calvarial defect reconstructionYingqi Chen , Sang-Ho Ye , Hideyoshi Sato , Yang Zhu , Vesselin Shanov , Tarannum Tiasha , Antonio D'Amore, Ph.D. , Samuel Luketich , Guojiang Wan , William R. Wagner
Journal of Tissue Engineering and Regenerative Medicine
https://doi.org/10.1002/term.2668Journal Paper
Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graft
Jeffrey T. Krawiec , Hans-Tsung Liao , LaiYee Lily Kwan , Antonio D'Amore, Ph.D. , Justin S. Weinbaum , J Peter Rubin , William R Wagner , David A Vorp
https://doi.org/10.1016/j.jvs.2016.09.034Patent
Bi-layer polyurethane - extra cellular matrix scaffolds for improved ischemic ventricular wall remodeling
EU Issued patent 3347063, 30-10-2025
Journal Paper
Mechanical and microstructural analysis of a radially expandable vascular conduit for neonatal and pediatric cardiovascular surgeryAbigail E. Loneker , Samuel K. Luketich , Doug Bernstein , Arush Kalra , Alan W. Nugent , Antonio D'Amore, Ph.D. , Denver M. Faulk
Journal of Biomedical Materials Research Part A
https://doi.org/10.1002/jbm.b.33874Journal Paper
Evaluation of the stromal vascular fraction of adipose tissue as the basis for a stem cell-based tissue-engineered vascular graftJeffrey T. Krawiec , Han-Tsung Liao , LaiYee (Lily) Kwan , Antonio D'Amore, Ph.D. , Justin S. Weinbaum , J. Peter Rubin , William R. Wagner , David A. Vorp
Journal of Vascular Surgery
Journal Paper
Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversionKristen M. Stearns-Reider , Antonio D'Amore, Ph.D. , Kevin Beezhold , Benjamin Rothrauff , Loredana Cavalli , William R. Wagner , David A. Vorp , Alkiviadis Tsamis , Sunita Shinde , Changqing Zhang , Aaron Barchowsky , Thomas A. Rando , Rocky S. Tuan , Fabrisia Ambrosio
Aging Cells
https://doi.org/10.1111/acel.12578Journal Paper
Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat modelAntonio D'Amore, Ph.D. , Tomo Yoshizumi , Samuel K. Luketich , Matthew T. Wolf , Xinzhu Gu , Marcello Cammarata , Richard Hoff , Stephen F. Badylak , William R. Wagner
Biomaterials
Patent
Retrievable self-expanding non- thrombogenic low-profile percutaneous atrioventricular valve prosthesisVinay Badhwar , Young Jae Chun , Antonio D'Amore, Ph.D. , David S. Schwartzman , William R. Wagner
US patent issued in 03-03-2026, publication number: US 12,564,492.
Licensed to Neoolife Inc. in 10-2020.
https://patents.google.com/patent/US10583004B2/en?inventor=%22Antonio%2bd%27Amore%22&oq=%22Antonio%2bd%27Amore%22Journal Paper
Large strain stimulation promotes extracellular matrix production and stiffness in an elastomeric scaffold modelAntonio D'Amore, Ph.D. , Joao S. Soares , John A. Stella , Will Zhang , Nicholas J. Amoroso , John E. Mayer , William R. Wagner , Michael S. Sacks
Journal of the Mechanical Behavior of Biomedical Materials
Journal Paper
In Vivo Functional Evaluation of Tissue-Engineered Vascular Grafts Fabricated Using Human Adipose-Derived Stem Cells from High Cardiovascular Risk PopulationsJeffrey T. Krawiec , Justin S. Weinbaum , Han-Tsung Liao , Aneesh K. Ramaswamy , Dominic J. Pezzone , Alexander D. Josowitz , Antonio D'Amore, Ph.D. , J. Peter Rubin , William R. Wagner , David A. Vorp
Tissue Engineering Part A
https://doi.org/10.1089/ten.tea.2015.0379Journal Paper
Extracellular matrix fiber microarchitecture is region-specific in bicuspid aortic valve-associated ascending aortopathyAlkiviadis Tsamis , Julie A. Phillippi , Ryan G. Koch , Patrick G. Chan , Jeffrey T. Krawiec , Antonio D'Amore, Ph.D. , Simon C. Watkins , William R. Wagner , David A. Vorp , Thomas G. Gleason
The Journal of Thoracic and Cardiovascular Surgery
Journal Paper
Arsenic Promotes NF‐Κb‐Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell FunctionChangqing Zhang , Ricardo Ferrari , Kevin Beezhold , Kristen Stearns-Reider , Antonio D'Amore, Ph.D. , Martin Haschak , Donna Stolz , Paul D. Robbins , Aaron Barchowsky , Fabrisia Ambrosio
Stem Cells
https://doi.org/10.1002/stem.2232Journal Paper
Geometric characterization and simulation of planar layered elastomeric fibrous biomaterials
James B. Carleton , Antonio D'Amore, Ph.D. , Kristen R. Feaver , Gregory J. Rodin , Michael S. Sacks
Acta Biomaterialia
Journal Paper
Fabrication of elastomeric scaffolds with curvilinear fibrous structures for heart valve leaflet engineeringChristopher M. Hobson , Nicholas J. Amoroso , Rouzbeh Amini , Ethan Ungchusri , Yi Hong , Antonio D'Amore, Ph.D. , Michael S. Sacks , William R. Wagner
Journal of Biomedical Materials Research Part A
https://doi.org/10.1002/jbm.a.35450Journal Paper
Correlations between transmural mechanical and morphological properties in porcine thoracic descending aortaAli Hemmasizadeh , Alkiviadis Tsamis , Rabee Cheheltani , Soroush Assari , Antonio D'Amore, Ph.D. , Michael Autieri , Mohammad F. Kiani , Nancy Pleshko , William R. Wagner , Simon C. Watkins , David Vorp , Kurosh Darvish
Journal of the Mechanical Behavior of Biomedical Materials
Journal Paper
Positive effects of an extracellular matrix hydrogel on rat anterior cruciate ligament fibroblast proliferation and collagen mRNA expressionRui Liang , Guoguang Yang , Kwang E. Kim , Antonio D'Amore, Ph.D. , Aimee N. Pickering , Cuiling Zhang , Savio L-Y. Woo
Journal of Orthopaedic Translation
Journal Paper
Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parametersSalvatore Pasta , Julie A. Phillippi , Alkiviadis Tsamis , Antonio D'Amore, Ph.D. , Giuseppe M. Raffa , Michele Pilato , Cesare Scardulla , Simon C. Watkins , William R. Wagner , Thomas G. Gleason , David A. Vorp
Medical Engineering & Physics
https://doi.org/10.1016/j.medengphy.2015.11.001Journal Paper
Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarctionTomo Yoshizumi , Yang Zhu , Hongbin Jiang , Antonio D'Amore, Ph.D. , Hirokazu Sakaguchi , Jason Tchao , Kimimasa Tobita , William R. Wagner
Biomaterials
Journal Paper
Solubilized liver extracellular matrix maintains primary rat hepatocyte phenotype in-vitroAbigail E. Loneker , Denver M. Faulk , George S. Hussey , Antonio D'Amore, Ph.D. , Stephen F. Badylak
Journal of Biomedical Material Research Part A
https://doi.org/10.1002/jbm.a.35636Journal Paper
Systems level approach reveals the correlation of endoderm differentiation of mouse embryonic stem cells with specific microstructural cues of fibrin gelsKeith Task , Antonio D'Amore, Ph.D. , Satish Singh , Joe Candiello , Maria Jaramillo , William R. Wagner , Prashant Kumta , Ipsita Banerjee
Journal of the Royal Society Interface
https://doi.org/10.1098/rsif.2014.0009Dissemination
Evaluating cells from liposuction aspirates for vascular tissue engineering
J. T. Krawiec , K. Bruce , A. Josowitz , L. Kokai , Antonio D'Amore, Ph.D. , J. Weinbaum , W. Wagner , P. Rubin , D. Vorp
Angiogenesis
Journal Paper
A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopyRyan G. Koch , Alkiviadis Tsamis , Antonio D'Amore, Ph.D. , William R. Wagner , Simon C. Watkins , Thomas G. Gleason , David A. Vorp
Journal of Biomechanics
Journal Paper
A mechanistic model on the role of “radially-running” collagen fibers on dissection properties of human ascending thoracic aortaSiladitya Pal , Alkiviadis Tsamis , Salvatore Pasta , Antonio D'Amore, Ph.D. , Thomas G. Gleason , David A. Vorp , Spandan Maiti
Journal of Biomechanics
Journal Paper
The effect of detergents on the basement membrane complex of a biologic scaffold materialD.M. Faulk , C.A. Carruthers , H.J. Warner , C.R. Kramer , J.E. Reing , L. Zhang , Antonio D'Amore, Ph.D. , S.F. Badylak
Acta Biomaterialia
Journal Paper
Nonthrombogenic, Biodegradable Elastomeric Polyurethanes with Variable Sulfobetaine ContentSang-Ho Ye , Yi Hong , Venkat Shankarraman , Samuel K. Luketich , Antonio D'Amore, Ph.D. , William R. Wagner
ACS Applied Materials & Interfaces
https://doi.org/10.1021/am506998sJournal Paper
From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterialsAntonio D'Amore, Ph.D. , Nicholas Amoroso , Riccardo Gottardi, PhD , Christopher Hobson , Christopher Carruthers , Simon Watkins , William R. Wagner , Michael S. Sacks
Journal of the Mechanical Behavior of Biomedical Materials
Journal Paper
Preparation and characterization of a biologic scaffold from esophageal mucosaTimothy J. Keane , Ricardo Londono , Ryan M. Carey , Christopher A. Carruthers , Janet E. Reing , Christopher L. Dearth , Antonio D'Amore, Ph.D. , Christopher J. Medberry , Stephen F. Badylak
Biomaterials
Journal Paper
Abdominal wall reconstruction by a regionally distinct biocomposite of extracellular matrix digest and a biodegradable elastomerKeisuke Takanari , Yi Hong , Ryotaro Hashizume , Alexander Huber , Nicholas J. Amoroso , Antonio D'Amore, Ph.D. , Stephen F. Badylak , William R. Wagner
Journal of Tissue Engineering and Regenerative Medicine
https://doi.org/10.1002/term.1834Dissemination
Collagen fiber architecture in the longitudinal-radial plane of ascending aorta is distinctly different among bicuspid aortic valve and tricuspid aortic valve patients with ascending aortic aneurysm
A. Tsamis , J.A. Phillippi , S. Pasta , Antonio D'Amore, Ph.D. , S. Watkins , W. Wagner , D. Vorp , T. Gleason
Cardiovascular Pathology
Journal Paper
Fiber micro-architecture in the longitudinal-radial and circumferential-radial planes of ascending thoracic aortic aneurysm mediaAlkiviadis Tsamis , Julie A. Phillippi , Ryan G. Koch , Salvatore Pasta , Antonio D'Amore, Ph.D. , Simon C. Watkins , William R. Wagner , Thomas G. Gleason , David A. Vorp
Journal of Biomechanics
Book/Book Chapter
Biomechanics and Finite Element Analysis
Michael Sacks , Antonio D'Amore, Ph.D. , Hobson Chistopher
Biomaterials Science: An Introduction to Materials in Medicine, 3rd ed., Chapter I.1.4 "Biomechanics and Finite Element Analysis." Eds. Ratner, Hoffman, Schoen & Lemons. Elsevier Publisher, 2012. ISBN 9780123746269
Dissemination
Fiber distribution of ascending thoracic aortic aneurysms associated with valve morphologyS. Pasta , J. Philippi , Antonio D'Amore, Ph.D. , W. R. Wagner , S. Watkins , T. Gleason , D. Vorp
Journal of Biomechanics
https://dx.doi.org/http://dx.doi.org/10.1016/S0021-9290(12)70125-2Dissemination
Controlling micro-structure to enhance de novo extracellular matrix deposition in elastomeric scaffolds for cardiac tissue regeneration
Antonio D'Amore, Ph.D. , J. Stella , R. Hoff , N. Amoroso , M. Sacks , W. R. Wagner
Journal of Tissue Engineering and Regenerative Medicine
Dissemination
Extracellular Matrix Hydrogels Prepared from Porcine Dermis and Urinary Bladder: Structure, Mechanics and In Vivo Remodeling
M. Wolf , K. Daly , E. Brennan-Pierce , S. Johnson , C. Carruthers , Antonio D'Amore, Ph.D. , S. Nagarkar , S. Velankar , S. Badylak
Glycobiology
Journal Paper
Microstructural manipulation of electrospun scaffolds for specific bending stiffness for heart valve tissue engineeringNicholas J. Amoroso , Antonio D'Amore, Ph.D. , Yi Hong , Christian P. Rivera , Michael S. Sacks , William R. Wagner
Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2012.08.002Journal Paper
Effects of fabrication on the mechanics, microstructure and micromechanical environment of small intestinal submucosa scaffolds for vascular tissue engineeringDiana M. Sánchez-Palencia , Antonio D'Amore, Ph.D. , Andrés González-Mancera , William R. Wagner , Juan C. Briceño
Journal of Biomechanics
Dissemination
Unseeded Engineered Valve Leaflets Retain Function and Remodel After Implant in Sheep Right Pulmonary Outflow TractA. S Bayoumi , Antonio D'Amore, Ph.D. , E. Aikawa , N. Amoroso , S. E New , A. Cubberley , P. Chen , K. Shapero , R.F Padera , F. J Schoen , W. R Wagner , M. S Sacks , J. E Mayer
CIRCULATION
https://dx.doi.org/http://circ.ahajournals.org/cgi/content/meeting_abstract/126/21_MeetingAbstracts/A19201Journal Paper
Elastomeric Electrospun Polyurethane Scaffolds: The Interrelationship Between Fabrication Conditions, Fiber Topology, and Mechanical PropertiesNicholas J. Amoroso , Antonio D'Amore, Ph.D. , Yi Hong , William R. Wagner , Michael S. Sacks
Advanced materials
https://doi.org/10.1002/adma.201003210Book/Book Chapter
The mechanics of native and engineered cardiac soft tissues
Michael S. Sacks , S. Wognum , J. Stella , E. Joyce , Antonio D'Amore, Ph.D. ,
Comprehensive Biomaterials, Page 27 of 42 Chapter 94 “The Mechanics of Native and Engineered Cardiac Soft Tissue”. Volume 3, 113-132. Elsevier Publisher, 2011. ISBN: 9780080553023
Journal Paper
A hydrogel derived from decellularized dermal extracellular matrixMatthew T. Wolf , Kerry A. Daly , Ellen P. Brennan-Pierce , Scott A. Johnson , Christopher A. Carruthers , Antonio D'Amore, Ph.D. , Shailesh P. Nagarkar , Sachin S. Velankar , Stephen F. Badylak
Biomaterials
