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Method and System for the Evaluation of the Risk of Aortic Rupture or Dissection in an Individual with an Ascending Thoracic Aortic Aneurysm



A method for calculating the risk of aortic rupture or dissection of an individual with an ascending thoracic aortic aneurysm, ATAA, comprising the steps of obtaining (10) a first data set (12) linked to the clinical and/or demographic characteristics of the individual, obtaining (20) a second data set (22) linked to the biochemical characteristics of a biological sample of the individual, obtaining (30) a third data set (32) linked to the morphological and functional characteristics of the aorta and processing said third data set (32) to obtain (40) a fourth data set (42) by computational modelling, integrating the first data set (12), the second data set (22), the third data set (32) and the fourth data set (42) in a predictive model to obtain a risk index (i) of aortic rupture or dissection, wherein the second data set (22) comprises expression values of at least one biomarker.


Salvatore Pasta, Cesare Scardulla

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