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Cinzia Maria Chinnici
Cinzia Chinnici, PhD
Principal Investigator in Cell Therapy
cchinnici@fondazionerimed.com

BIOSKETCH

Cinzia initiated her scientific career with the completion of a Ph.D in Animal Biology from the University of Palermo, in 2003. In the same year, she moved to Philadelphia (USA), where she spent three years as a Postdoctoral Researcher at the University of Pennsylvania. In 2006, she returned to Italy as an Associate Researcher at IRCCS ISMETT. Her appointment with Fondazione Ri.MED began in 2008, initially as an Associate Researcher and subsequently as a Senior Scientist. Meanwhile, her research focus was centered around the establishment of cellular therapies aimed at restoring organ function, and she became responsible for the production of human fetal liver cells to be transplanted to cirrhotic patients. More recently, her scientific interest has shifted towards the development of a cell-free therapy based on secretome and extracellular vesicles from human mesenchymal stromal cells. Since 2022, she is Principal Investigator leading the Cell Therapy group.

SCIENTIFIC ACTIVITY

The Cell Therapy group is primarily dedicated in optimizing the cell-free therapy through the utilization of polymer-based delivery systems. Particularly, Cinzia has developed a biomedical device consisting of a hydrogel sponge integrated with secretome of mesenchymal stromal cells for the treatment for chronic skin wounds. The device has shown promising results in a murine model of diabetic foot ulcer (proof-of-concept of efficacy), and is now advancing to the validation phase. Recently, she is also working to develop extracellular vesicle/microRNA-based treatments for chronic liver diseases, such as non-alcoholic steatohepatitis (NASH) (HALIFIB project).

Publications

Journal Paper
Topical application of a hyaluronic acid-based hydrogel integrated with secretome of human mesenchymal stromal cells for diabetic ulcer repair
Fabio S Palumbo , Matteo Calligaris , Laura Calzà , Calogero Fiorica , Vito A Baldassarro , Anna Paola Carreca , Luca Lorenzini , Claudia Carcione , Nicola Cuscino , Giovanna Pitarresi , Simone Dario Scilabra, PhD , Pier Giulio Conaldi , Cinzia Chinnici, Ph.D *
Regen Ther. 2024 Jul 27;26:520-532
https://pubmed.ncbi.nlm.nih.gov/39156755/
Journal Paper
Proteomic analysis and functional validation reveal distinct therapeutic capabilities related to priming of mesenchymal stromal/stem cells with IFN-γ and hypoxia: potential implications for their clinical use
Matteo Calligaris , Giovanni Zito , Rosalia Busà , Matteo Bulati , Gioacchin Iannolo , Alessia Gallo , Anna Paola Carreca , Nicola Cuscino , Salvatore Castelbuono , Claudia Carcione , Claudio Centi , Giandomenico Amico, PhD , Alessandro Bertani , Cinzia Chinnici, Ph.D , Pier Giulio Conaldi , Simone Dario Scilabra, PhD , Vitale Miceli
https://doi.org/10.3389/fcell.2024.1385712
Journal Paper
miRNA expression analysis in the human heart: Undifferentiated progenitors vs. bioptic tissues—Implications for proliferation and ageing
Gioacchin Iannolo , Maria Rita Sciuto , Nicola Cuscino , Claudia Carcione , Claudia Coronnello, PhD , Cinzia Chinnici, Ph.D , Giuseppe Maria Raffa , Michele Pilato , Pier Giulio Conaldi
Journal of Cellular and Molecular Medicine25(18):8687-8700, 2021
https://doi.org/10.1111/jcmm.16824
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