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Mariangela Di Bella
Mariangela Di Bella
Senior Specialist in Cell Production
mbella@fondazionerimed.com

She graduated in March 1999 in biological sciences at the University of Palermo. She made postgraduate training course at the laboratory of Mycology and Chlamydia of Hygiene Department at the University of Palermo. From 2000 to 2006 she was voluntary researcher at the Laboratory of Immunopathology of the University of Palermo by participating in research and diagnostic activities; in particular the activity concerned the assessment of airway inflammation in asthma and COPD, allergies, diagnostic analysis and characterization of bronchoalveolar lavage cells and induced sputum. Between 2002 and 2006 she also collaborated with the Bone Hope Project for the “Registry of Pathology for lung and pleura cancer in Palermo”. From November 2006 until December 2008 she assumed the title of biologist at the Clinical and Microbiological Laboratory of ISMETT participating in research and diagnostic activities. Since January 2009, in collaboration with UPMC Italy and the Unit of Regenerative Medicine, she collaborated to develop clinical protocols for adoptive immunotherapy. According to GMP standards (Good Manufacturing Practice), she actively participated in selection and in vitro expansion of Cytomegalovirus and Epstein Barr Virus specific cytotoxic T lymphocytes. She also attended to isolation of islets of Langerhans from the pancreas of human cadaver donors and to isolation of human fetal hepatocytes. She also analyzed and characterized bronchoalveolar lavage cells in pigs for the preclinical research laboratory. Since July 2012 she has been working as an expert technologist in cell production for the Ri.MED Foundation at the Regenerative Medicine and Biomedical Technologies Unit, dealing with the implementation of the project “Adoptive cellular immunotherapy of post-transplant viral infections”, collaborating with the Control Quality in the drafting of method validations; collaborates in the study of the cell-mediated response via Elispot tests in patients with severe complications from COVID, in vaccinated transplant patients and in immunocompetent vaccinated subjects, also collaborating in the review of clinical trial data and in the drafting of scientific works; participates in the collection of biological samples, as part of the monitoring of HHV8 infection post-transplant, performed with the isolation and storage of PBMCs from blood and evaluation of the cell-mediated response via Elispot tests.

 

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