The MusculoSkeletal Tissue Engineering (MSTE) group is dedicated to pursuing as a main objective the advancement of groundbreaking strategies for the treatment of various pathologies that affect ligaments, tendons, cartilage, bone, and muscles.
In order to achieve this goal, the MSTE group employs a wide range of innovative approaches relying on tissue engineering technologies. These approaches are based on the most advanced techniques of biofabrication, including but not limited to 3D printing, electric-field induced biofabrication, and bioprinting.
The primary focus of the MSTE group is to fabricate bioactive scaffolds able to provide pro-regenerative cues for cells that are either seeded onto or embedded within these kinds of 3D supports. Following this approach, we aim to support reconstructive surgery after tendons/ligaments injuries promoting the regeneration of functional tissue in the mid-term. Analogously, our activity aims to restore the functionality of joints affected by focal chondral defects developing functional scaffolds stimuli-responsive, with a vision toward a clinical translation in the near future. In addition, the MSTE group is leading several projects aimed to the development of highly realistic ex vivo models of pathologies affecting the musculoskeletal system. Such an activity is supported by the employment of a proprietary technology based on macro-fluidic bioreactors for the culturing of biphasic tissues in native-like conditions.
The MSTE group is actively involved in numerous collaborations with international partners, which allow the design and management of different interdisciplinary projects.  These collaborations serve as a fertile ground for the exchange of knowledge, expertise, and resources, enabling the MSTE group to push forward the boundaries of innovation. In this direction, we are developing engineered models of muscle tissue with a specific focus on fill the gap in the knowledge of the intricate interplay between the pathologies affecting the nervous system and the musculoskeletal apparatus. This groundbreaking research provides a deeper insight into the mechanisms underlying various neuromuscular disorders and facilitates the exploration of innovative therapeutic approaches.

Team