Chiara Cipollina, PhD
Group Leader in Experimental Lung Research
ccipollina@fondazionerimed.com
Biographical Notes
In 2003 I was awarded MSc degree in Biotechnology at the University of Milano-Bicocca (Italy) where I also started my PhD studentship in Industrial Biotechnologies (2003-2006) with a project in collaboration with the Delft University of Technology (TU Delft, The Netherlands). Between 2006 and 2008 I continued my research activity as Postoctoral Researcher in the Department of Biotechnology at TU Delft focusing on the quantitative understanding of yeast metabolism and on the successful application of metabolic engineering approaches for the production of biofuel. My switch to biomedical research happened in 2008, when I was granted a two-year Ri.MED PostDoctoral Fellowship at the University of Pittsburgh (USA), Department of Pharmacology and Chemical Biology under the guidance of Prof. Bruce Freeman. At Pitt, between 2008 and 2010, my expertise on mass spectrometry-based quantitative analysis of cellular metabolism served to the study of inflammatory reactions and contributed to the discovery of novel endogenous mediators of inflammation resolution. In 2010 I moved to Palermo as Ri.MED Research Fellow at the Institute of Biomedical Research and Innovation (IRIB-CNR) joining the group of Experimental Pneumology led by Dr. Elisabetta Pace where I combined my expertise on inflammatory research with a new interest for chronic lung diseases. Since 2017 I have started my own research lab focusing on innate immunity and lung diseases.
Scientific Activities
We study the innate immune response, with a focus on lung diseases. Non-communicable chronic diseases are characterized by a complex inflammatory scenario, very often involving sterile inflammation, whose mechanisms are still not well understood. We think regulated cell death of myeloid cells in the lung may be a key trigger for chronic inflammation. In this respect, macrophages appear to play a common role in many lung diseases, including COPD, fibrosis and cancer. We aim at discovering key molecular players through which macrophages promote chronic inflammation in the lung.
I am currently directing the Screening Platform within the Drug Discovery Area.
ORCID: https://orcid.org/0000-0002-0712-8440
Scopus ID: 8417898300
Publications
Journal Paper
Multiplex on-chip immunosensor for advancing inflammation biomarkers monitoring
Nadia Moukri , Vuslat Juska , Bernardo Patella , Maria Rita Giuffrè , Elisabetta Pace , Chiara Cipollina, PhD , Alan O’Riordan , Rosalinda Inguanta
Sensors and Actuators: B. Chemical
https://doi.org/10.1016/j.snb.2025.138604Journal Paper
Caspase inhibition restores collagen Ia1 and fibronectin release in cigarette smoke extract-exposed human lung fibroblasts
Agnese La Mensa , Marco Buscetta, PhD , Roy R. Woldhuis , Maura Cimino , Maria Rita Giuffrè , Marta Cristaldi , Paola Dino , Luigi Fiore , Alberto Fucarino , Giovanna Lo Iacono , Alessandro Bertani , Corry-Anke Brandsma , Fabio Bucchieri , Chiara Cipollina, PhD
American Journal of Physiology: Lung Cellular and Molecular Physiology
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Mitochondria-targeted rosmarinic acid: Its role against oxidative damage
Antonella Girgenti , Pasquale Picone , Miriam Buttacavoli , Laura Palumbo , Flores Naselli , Elena Lo Presti , Desirèe Pecora , Chiara Cipollina, PhD , Francesca Annunziata , Andrea Pinto , Lucia Tamborini , Domenico Nuzzo
Biomedicine & Pharmacotherapy
https://doi.org/10.1016/j.biopha.2025.118114Journal Paper
Editorial: Cell death in innate immunity and inflammatory diseases
Malvina Pizzuto , Chiara Cipollina, PhD
Frontiers in Immunology
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Anti-Apoptotic and Anti-Inflammatory Properties of Grapefruit IntegroPectin on Human Microglial HMC3 Cell Line
Miriana Scordino , Giulia Urone , Monica Frinchi , Chiara Valenza , Angela Bonura , Chiara Cipollina, PhD , Rosaria Ciriminna , Francesco Meneguzzo , Mario Pagliaro , Giuseppa Mudò , Valentina Di Liberto
cells
https://doi.org/10.3390/cells13040355Journal Paper
Brain biodistribution of myelin nanovesicles with targeting potential for multiple sclerosis
Pasquale Picone , Fabio Salvatore Palumbo , Francesco Cancilla , Antonella Girgenti , Patrizia Cancemi , Vera Muccilli , Antonella Di Francesco , Maura Cimino , Chiara Cipollina, PhD , Marzia Soligo , Luigi Manni , Gianluca Sferrazza , Luca Scalisi , Domenico Nuzzo
Acta Biomaterialia
https://doi.org/10.1016/j.actbio.2024.08.016Journal Paper
Gold nanowires-based sensor for quantification of H2O2 released by human airway epithelial cells
Bernardo Patella , Serena Di Vincenzo , Nadia Moukri , Francesco Bonafede , Maria Ferraro , Valentina Lazzara , Maria Rita Giuffrè , Sonia Carbone , Giuseppe Aiello , Michele Russo , Chiara Cipollina, PhD , Rosalinda Inguanta , Elisabetta Pace
Talanta
https://doi.org/10.1016/j.talanta.2024.125772Research project
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Release of IL-1β and IL-18 in human primary bronchial epithelial cells exposed to cigarette smoke is independent of NLRP3
Paola Dino , Maria Rita Giuffrè , Marco Buscetta, PhD , Serena Di Vincenzo , Agnese La Mensa , Marta Cristaldi , Fabio Bucchieri , Giovanna Lo Iacono , Alessandro Bertani , Elisabetta Pace , Chiara Cipollina, PhD
European Journal of Immunology
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Tyndallized bacteria prime bronchial epithelial cells to mount an effective innate immune response against infections
Serena Di Vincenzo , Caterina Di Sano , Claudia D’Anna , Maria Ferraro , Velia Malizia , Andreina Bruno , Marta Cristaldi , Chiara Cipollina, PhD , Valentina Lazzara , Paola Pinto , Stefania La Grutta , Elisabetta Pace
Human Cell
https://doi.org/10.1007/s13577-024-01080-zResearch project
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Wearable sensor for real-time monitoring of oxidative stress in simulated exhaled breath
M.G. Bruno , B. Patella , M. Ferraro , S. Di Vincenzo , P. Pinto , C. Torino , A. Vilasi , Maria Rita Giuffrè , V.B. Juska , A. O’Riordan , R. Inguanta , Chiara Cipollina, PhD , E. Pace , G. Aiello
Biosensors and Bioelectronics: X
https://doi.org/10.1016/j.biosx.2024.100476Research project
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Wearable Sensor for Real-Time Monitoring of Hydrogen Peroxide in Simulated Exhaled AirBruno, Maria G , Patella, Bernardo , Aiello, Giuseppe , Torino, Claudia , Vilasi, Antonio , Chiara Cipollina, PhD , Vincenzo, Serena Di , Pace, Elisabetta , Riordan, Alan , Inguanta, Rosalinda
Chemical Engineering Transactions, 2023, 100: 655-660
https://doi.org/10.3303/CET23100110Journal Paper
In‑silico guided chemical exploration of KDM4A fragments hits
Jessica Lombino , Rosario Vallone , Maura Cimino , Maria Rita Gulotta, PhD , Giada De Simone , Maria Agnese Morando , Raffaele Sabbatella , Simona Di Martino, Ph.D. , Mario Fogazza , Federica Sarno , Claudia Coronnello, PhD , Maria De Rosa, PhD , Chiara Cipollina, PhD , Lucia Altucci , Ugo Perricone, Ph.D. , Caterina Alfano, PhD
https://doi.org/10.1186/s13148-023-01613-7Research project
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In‑silico guided chemical exploration of KDM4A fragments hitsJessica Lombino , Rosario Vallone , Maura Cimino , Maria Rita Gulotta, PhD , Giada de Simone , Maria Agnese Morando, PhD , Raffaele Sabbatella , Simona Di Martino, Ph.D. , Mario Fogazza , Federica Sarno , Claudia Coronnello, PhD , Maria De Rosa, PhD , Chiara Cipollina, PhD , Lucia Altucci , Ugo Perricone, Ph.D. *, Caterina Alfano, PhD *
Clinical Epigenetics, 15(197):1-16, 2023
https://doi.org/10.1186/s13148-023-01613-7Research project
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Tyndallized Bacteria Preferentially Induce Human Macrophage M1 Polarization: An Effect Useful to Balance Allergic Immune Responses and to Control Infections
Serena Di Vincenzo , Simona Taverna , Velia Malizia , Marco Buscetta, PhD , Chiara Cipollina, PhD , Valentina Lazzara , Paola Pinto , M Bassano , Stefania La Grutta , Elisabetta Pace
Antibiotics 2023, 12(3), 571.
https://doi.org/10.3390/antibiotics12030571Research project
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Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharideMarta Cristaldi , Marco Buscetta, PhD , Maura Cimino , Agnese La Mensa , Maria Rita Giuffrè , Luigi Fiore , Claudia Carcione , Fabio Bucchieri , Francesca Rappa , Claudia Coronnello, PhD , Nicolina Sciaraffa, PhD , Santina Amato , Tommaso Silvano Aronica , Giovanna Lo Iacono , Alessandro Bertani , Elisabetta Pace , Chiara Cipollina, PhD ,
Cell Death Dis, 2023 Nov 25;14(11):773.
https://doi.org/10.1038/s41419-023-06318-6Research project
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Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke ExtractChiara Cipollina, PhD , Bruno Andreina , Fasola Salvatore , Marta Cristaldi , Patella Bernardo , Inguanta Rosalinda , Vilasi Antonio , Aiello Giuseppe , La Grutta Stefania , Torino Claudia , Pace Elisabetta
International Journal of Molecular Sciences
https://doi.org/10.3390/ijms23031770Research project
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Cigarette smoke promotes inflammasome-independent activation of caspase-1 and -4 leading to gasdermin D cleavage in human macrophagesMarco Buscetta, PhD , , , Agnese La Mensa , , Bucchieri, Fabio , Rappa, Francesca , Amato, Santina , Aronica, Tommaso Silvano , Pace, Elisabetta , Bertani, Alessandro , Chiara Cipollina, PhD
Faseb J
https://doi.org/10.1096/fj.202200837RResearch project
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Electrochemical Synthesis of Zinc Oxide Nanostructures on Flexible Substrate and Application as an Electrochemical Immunoglobulin-G ImmunosensorPatella Bernardo , Moukri, Nadia , Regalbuto Gaia , Chiara Cipollina, PhD , Pace Elisabetta , Di Vincenzo Serena , Aiello Giuseppe , O’riordan Alan , Inguanta Rosalinda
Materials
https://doi.org/10.3390/ma15030713Journal Paper
A novel healthcare 4.0 system for testing respiratory diseases based on nanostructured biosensors and fog networking
Islam Asem Salah Abusohyon , Giuseppe Aiello , Cinzia Muriana , Maria Giuseppina Bruno , Bernardo Patella , Maria Ferraro , Serena Di Vincenzo , Chiara Cipollina, PhD , Elisabetta Pace , Rosalinda Inguanta , Mo’men Abu Sahyoun
Computers & Industrial Engineering
https://doi.org/10.1016/j.cie.2024.110698Research project
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Journal Paper
Cigarette smoke upregulates Notch-1 signaling pathway and promotes lung adenocarcinoma progression
Chiappara, Giuseppina , Di Vincenzo, Serena , Sangiorgi, Claudia , Di Sano, Caterina , D'Anna, Claudia , Zito, Giovanni , Chiara Cipollina, PhD , Vitulo, Patrizio , Bertani, Alessandro , Pace, Elisabetta
Toxicology Letters
https://doi.org/10.1016/j.toxlet.2021.11.002Research project
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Electrochemical Quantification of H2O2 Released by Airway Cells Growing in Different Culture Media.Bernardo Patella , Serena Di Vincenzo , Claudio Zanca , Luciano Bollaci , Maria Ferraro , Maria Rita Giuffrè , Chiara Cipollina, PhD , Maria Giuseppina Bruno , Giuseppe Aiello , Michele Russo , Rosalinda Inguanta , Elisabetta Pace
https://doi.org/10.3390/mi13101762Research project
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Electrochemical sensor based on rGO/Au nanoparticles for monitoring H2O2 released by human macrophages
Patella, Bernardo , Marco Buscetta, PhD , Di Vincenzo, Serena , Ferraro, Maria , Aiello, Giuseppe , Sunseri, Carmelo , Pace, Elisabetta , Inguanta, Rosalinda , Chiara Cipollina, PhD
Sensors and Actuators, B: Chemical
https://doi.org/10.1016/j.snb.2020.128901Journal Paper
Cigarette Smoke Impairs Airway Epithelial Wound Repair: Role of Modulation of Epithelial-Mesenchymal Transition Processes and Notch-1 Signaling
Serena Di Vincenzo , Dennis K Ninaber , Chiara Cipollina, PhD , Maria Ferraro , Pieter S Hiemstra , Elisabetta Pace ,
Antioxidants
https://doi.org/10.3390/antiox11102018Research project
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Journal Paper
Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancerSerena Di Vincenzo , Claudia Sangiorgi , Maria Ferraro , Marco Buscetta, PhD , Chiara Cipollina, PhD , Elisabetta Pace
Toxicology
https://doi.org/10.1016/j.tox.2021.152751Research project
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miR-1207-5p Can Contribute to Dysregulation of Inflammatory Response in COVID-19 via Targeting SARS-CoV-2 RNABertolazzi, Giorgio , Chiara Cipollina, PhD , Benos, Panayiotis V , Tumminello, Michele , Claudia Coronnello, PhD
Frontiers in Cellular and Infection Microbiology, 10:586592, 2020
https://doi.org/10.3389/fcimb.2020.586592Research project
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Cigarette smoke inhibits the NLRP3 inflammasome and leads to caspase-1 activation via the TLR4-TRIF-caspase-8 axis in human macrophages
Marco Buscetta, PhD , Di Vincenzo, Serena , Monica Miele, PhD , Ester Badami, PhD , Pace, Elisabetta , Chiara Cipollina, PhD
FASEB Journal
https://doi.org/10.1096/fj.201901239RResearch project
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In silico insights towards the identification of NLRP3 druggable hot spots
, Maria De Rosa, PhD , Chiara Cipollina, PhD , Maria Rita Gulotta, PhD , Giada de Simone , Lombino, Jessica , Padova, Alessandro , Ugo Perricone, Ph.D.
International Journal of Molecular Sciences
https://doi.org/10.3390/ijms20204974Journal Paper
Cellular models and assays to study NLRP3 inflammasome biology
International Journal of Molecular Sciences
https://doi.org/10.3390/ijms21124294Research project
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Journal Paper
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke
Ferraro M. , Di Vincenzo S. , , Bucchieri S , Chiara Cipollina, PhD , Gjomarkaj M , Pace E
Experimental Gerontology
https://doi.org/10.1016/j.exger.2019.01.016Research project
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SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells
Di Vincenzo, Serena , Heijink, Irene H , Noordhoek, Jacobien A , Chiara Cipollina, PhD , Siena, Liboria , Bruno, Andreina , Ferraro, Maria , Postma, Dirkje S , Gjomarkaj, Mark , Pace, Elisabetta
Journal of Cellular and Molecular Medicine
https://doi.org/10.1111/jcmm.13509Research project
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Electrophilic derivatives of omega-3 fatty acids counteract lung cancer cell growth
Siena, Liboria , Chiara Cipollina, PhD , Di Vincenzo, Serena , Ferraro, Maria , Bruno, Andreina , Gjomarkaj, Mark , Pace, Elisabetta
Cancer Chemotherapy and Pharmacology
https://doi.org/10.1007/s00280-018-3538-3Journal Paper
Ceftaroline modulates the innate immune and host defense responses of immunocompetent cells exposed to cigarette smoke
Bruno A. , Chiara Cipollina, PhD , Di Vincenzo S. , Siena L. , , Di Gaudio F , Gjomarkaj M , Pace E
Toxicology Letters
https://doi.org/10.1016/j.toxlet.2017.07.878Research project
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17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the NLRP3 inflammasome
Chiara Cipollina, PhD , Di Vincenzo, Serena , Siena, Liboria , Di Sano, Caterina , Gjomarkaj, Mark , Pace, Elisabetta
Scientific Reports
https://doi.org/10.1038/srep37625Research project
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Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives
BioMed Research International
https://doi.org/10.1155/2015/501792Research project
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Book/Book Chapter
Electrophilic Derivatives of Omega-3 Fatty Acids for the Cure and Prevention of Neurodegenerative Disorders
Chiara Cipollina, PhD , Schopfer, Francisco J. ,
Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy
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Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives
Chiara Cipollina, PhD , Salvatore, Sonia R , Muldoon, Matthew F , Freeman, Bruce A , Schopfer, Francisco J
PLoS ONE
https://doi.org/10.1371/journal.pone.0094836Research project
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TLR4 Up-regulation and reduced Foxp3 expression in mechanically ventilated smokers with obstructive chronic bronchitis
Pace, Elisabetta , Ferraro, Maria , Giarratano, Antonino , Chiara Cipollina, PhD , Gjomarkaj, Mark
COPD: Journal of Chronic Obstructive Pulmonary Disease
https://doi.org/10.3109/15412555.2012.730565Research project
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Comparative cytoprotective effects of carbocysteine and fluticasone propionate in cigarette smoke extract-stimulated bronchial epithelial cells
Pace, Elisabetta , Ferraro, Maria , Di Vincenzo, Serena , Chiara Cipollina, PhD , Gerbino, Stefania , Cigna, Diego , Caputo, Valentina , Balsamo, Rossella , Lanata, Luigi , Gjomarkaj, Mark
Cell Stress and Chaperones
https://doi.org/10.1007/s12192-013-0424-0Research project
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Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation
Chiara Cipollina, PhD , Di Vincenzo, Serena , Gerbino, Stefania , Siena, Liboria , Gjomarkaj, Mark , Pace, Elisabetta
Biochimica et Biophysica Acta - General Subjects
https://doi.org/10.1016/j.bbagen.2014.02.024Research project
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Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids
Groeger, Alison L , Chiara Cipollina, PhD , Cole, Marsha P , Woodcock, Steven R , Bonacci, Gustavo , Rudolph, Tanja K , Rudolph, Volker , Freeman, Bruce A , Schopfer, Francisco J
Nature Chemical Biology
https://doi.org/10.1038/nchembio.367Research project
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Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae
Wisselink, H. Wouter , Chiara Cipollina, PhD , Oud, Bart , Crimi, Barbara , Heijnen, Joseph J. , Pronk, Jack T , van Maris, Antonius J.A
Metabolic Engineering
https://doi.org/10.1016/j.ymben.2010.08.003Research project
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A comprehensive method for the quantification of the non-oxidative pentose phosphate pathway intermediates in Saccharomyces cerevisiae by GC-IDMS
Chiara Cipollina, PhD , ten Pierick, Angela , Canelas, André B , Seifar, Reza M , van Maris, Antonius J.A. , van Dam, Jan C , Heijnen, Joseph J
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
https://doi.org/10.1016/j.jchromb.2009.07.019Research project
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Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: A chemostat study
Chiara Cipollina, PhD , van den Brink, Joost , Daran-Lapujade, Pascale , Pronk, Jack T , Vai, Marina , de Winde, Johannes H
Microbiology
https://doi.org/10.1099/mic.0.2007/011767-0Research project
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Saccharomyces cerevisiae SFP1: At the crossroads of central metabolism and ribosome biogenesis
Chiara Cipollina, PhD , van den Brink, Joost , Daran-Lapujade, Pascale , Pronk, Jack T , Porro, Danilo , de Winde, Johannes H.
Microbiology
https://doi.org/10.1099/mic.0.2008/017392-0Research project
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Towards understanding of the complex structure of growing yeast populations
Chiara Cipollina, PhD , Vai, Marina , Porro, Danilo , Hatzis, Christos
Journal of Biotechnology
https://doi.org/10.1016/j.jbiotec.2006.10.012Research project
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SFPI is involved in cell size modulation in respiro-fermentative growth conditions
Chiara Cipollina, PhD , Alberghina, Lilia , Porro, Danilo , Vai, Marina
Yeast
https://doi.org/10.1002/yea.1218Research project
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