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IMG_6355
Chiara Cipollina, PhD
Group Leader in Experimental Lung Research
ccipollina@fondazionerimed.com

Biographical Notes

In 2003 I was awarded MSc degree in Biotechnology at the University of Milano-Bicocca (Italy) where I also started my PhD studentship in Industrial Biotechnologies (2003-2006) with a project in collaboration with the Delft University of Technology (TU Delft, The Netherlands). Between 2006 and 2008 I continued my research activity as Postoctoral Researcher in the Department of Biotechnology at TU Delft focusing on the quantitative understanding of yeast metabolism and on the successful application of metabolic engineering approaches for the production of biofuel.  My switch to biomedical research happened in 2008, when I was granted a two-year Ri.MED PostDoctoral Fellowship at the University of Pittsburgh (USA), Department of Pharmacology and Chemical Biology under the guidance of Prof. Bruce Freeman. At Pitt, between 2008 and 2010, my expertise on mass spectrometry-based quantitative analysis of cellular metabolism served to the study of inflammatory reactions and contributed to the discovery of novel endogenous mediators of inflammation resolution. In 2010 I moved to Palermo as Ri.MED Research Fellow at the Institute of Biomedical Research and Innovation (IRIB-CNR) joining the group of Experimental Pneumology led by Dr. Elisabetta Pace where I combined my expertise on inflammatory research with a new interest for chronic lung diseases. Since 2017 I have started my own research lab focusing on innate immunity and lung diseases.

Scientific Activities

We study the innate immune response, with a focus on lung diseases. Non-communicable chronic diseases are characterized by a complex inflammatory scenario, very often involving sterile inflammation, whose mechanisms are still not well understood. We think regulated cell death of myeloid cells in the lung may be a key trigger for chronic inflammation. In this respect, macrophages appear to play a common role in many lung diseases, including COPD, fibrosis and cancer. We aim at discovering key molecular players through which macrophages promote chronic inflammation in the lung.

I am currently directing the Screening Platform within the Drug Discovery Area.

ORCID: https://orcid.org/0000-0002-0712-8440

Scopus ID:  8417898300

LinkedIn: www.linkedin.com/in/chiara-cipollina-727ab711

Publications

Journal Paper
Tyndallized Bacteria Preferentially Induce Human Macrophage M1 Polarization: An Effect Useful to Balance Allergic Immune Responses and to Control Infections
Serena Di Vincenzo , Simona Taverna , Velia Malizia , Marco Buscetta, PhD , Chiara Cipollina, PhD , Valentina Lazzara , Paola Pinto , M Bassano , Stefania La Grutta , Elisabetta Pace
Antibiotics 2023, 12(3), 571.
https://doi.org/10.3390/antibiotics12030571
Journal Paper
Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide
Marta Cristaldi , Marco Buscetta, PhD , Maura Cimino , Agnese La Mensa , Maria Rita Giuffrè , Luigi Fiore , Claudia Carcione , Fabio Bucchieri , Francesca Rappa , Claudia Coronnello, PhD , Nicolina Sciaraffa, PhD , Santina Amato , Tommaso Silvano Aronica , Giovanna Lo Iacono , Alessandro Bertani , Elisabetta Pace , Chiara Cipollina, PhD ,
Cell Death Dis, 2023 Nov 25;14(11):773.
https://doi.org/10.1038/s41419-023-06318-6
Journal Paper
Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
Chiara Cipollina, PhD , Bruno Andreina , Fasola Salvatore , Marta Cristaldi , Patella Bernardo , Inguanta Rosalinda , Vilasi Antonio , Aiello Giuseppe , La Grutta Stefania , Torino Claudia , Pace Elisabetta
International Journal of Molecular Sciences
https://doi.org/10.3390/ijms23031770
Book/Book Chapter
Electrophilic Derivatives of Omega-3 Fatty Acids for the Cure and Prevention of Neurodegenerative Disorders
Chiara Cipollina, PhD , Schopfer, Francisco J. ,
Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy
Journal Paper
Comparative cytoprotective effects of carbocysteine and fluticasone propionate in cigarette smoke extract-stimulated bronchial epithelial cells
Pace, Elisabetta , Ferraro, Maria , Di Vincenzo, Serena , Chiara Cipollina, PhD , Gerbino, Stefania , Cigna, Diego , Caputo, Valentina , Balsamo, Rossella , Lanata, Luigi , Gjomarkaj, Mark
Cell Stress and Chaperones
https://doi.org/10.1007/s12192-013-0424-0
Journal Paper
Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation
Chiara Cipollina, PhD , Di Vincenzo, Serena , Gerbino, Stefania , Siena, Liboria , Gjomarkaj, Mark , Pace, Elisabetta
Biochimica et Biophysica Acta - General Subjects
https://doi.org/10.1016/j.bbagen.2014.02.024
Journal Paper
Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae
Wisselink, H. Wouter , Chiara Cipollina, PhD , Oud, Bart , Crimi, Barbara , Heijnen, Joseph J. , Pronk, Jack T , van Maris, Antonius J.A
Metabolic Engineering
https://doi.org/10.1016/j.ymben.2010.08.003
Journal Paper
Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids
Groeger, Alison L , Chiara Cipollina, PhD , Cole, Marsha P , Woodcock, Steven R , Bonacci, Gustavo , Rudolph, Tanja K , Rudolph, Volker , Freeman, Bruce A , Schopfer, Francisco J
Nature Chemical Biology
https://doi.org/10.1038/nchembio.367
Journal Paper
A comprehensive method for the quantification of the non-oxidative pentose phosphate pathway intermediates in Saccharomyces cerevisiae by GC-IDMS
Chiara Cipollina, PhD , ten Pierick, Angela , Canelas, André B , Seifar, Reza M , van Maris, Antonius J.A. , van Dam, Jan C , Heijnen, Joseph J
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
https://doi.org/10.1016/j.jchromb.2009.07.019
Journal Paper
Saccharomyces cerevisiae SFP1: At the crossroads of central metabolism and ribosome biogenesis
Chiara Cipollina, PhD , van den Brink, Joost , Daran-Lapujade, Pascale , Pronk, Jack T , Porro, Danilo , de Winde, Johannes H.
Microbiology
https://doi.org/10.1099/mic.0.2008/017392-0
Journal Paper
Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: A chemostat study
Chiara Cipollina, PhD , van den Brink, Joost , Daran-Lapujade, Pascale , Pronk, Jack T , Vai, Marina , de Winde, Johannes H
Microbiology
https://doi.org/10.1099/mic.0.2007/011767-0
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