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Contatti:

Via Ugo La Malfa 153

90146 Palermo
ccipollina@fondazionerimed.com

Facilities:

Screening

Collaborazioni:

  • IRCCS ISMETT, Palermo, Italia;
  • University Medical Center Groningen, Groningen, The Netherlands;
  • Istituto di Farmacologia Traslazionale (IFT)-CNR, Palermo, Italia;
  • Istituto per la Ricerca e l’Innovazione Biomedica (IRIB) – CNR, Palermo, Italia;
  • Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata, Università Degli Studi di Palermo, Palermo, Italia;
  • Dipartimento di Ingegneria Chimica dei Processi e dei Materiali, Università Degli Studi di Palermo, Palermo, Italia;
  • Azienda di Rilievo Nazionale ed Alta Specializzazione Ospedali (A.R.N.A.S) “Civico Di Cristina Benfratelli”, Palermo, Italia;
  • Università degli Studi di Messina, Messina, Italia;

Descrizione

We study the innate immune response in respiratory lung diseases, both in chronic conditions such as cigarette smoke (CS)-associated lung diseases as well as in acute settings such as infections. Under homeostatic conditions, alveolar macrophages are the most abundant myeloid cells in the alveolar space and play a key role in orchestrating first line host defenses. Our research focuses on macrophage-associated immune responses. We are particularly interested in studying how inflammasomes, caspases, and regulated cell death participate to inflammatory reactions in health and disease. We are also investigating the impact of the pore-forming proteins gasdermins (GSDMs) on the surrounding inflammatory milieu. Growing evidence suggests that monitoring and fine-tuning cell death may provide a tool for assess chronic inflammation and develop new therapies.

A key asset of our lab is the availability and the continuous set-up of new experimental models using human primary cells that we isolate from buffy coats and lung resections. These experimental models are also used as a tool for the development and validation of innovative biosensors for oxidative stress and inflammation within a consolidated collaboration with the Engineering Department at the University of Palermo.

Our Lab is currently hosted by the National Research Council of Palermo  and hosts the Screening Lab of the Fondazione Ri.MED Drug Discovery Unit.

Team

Luigi Fiore

PhD Student in Translational Molecular Medicine and Surgery, Università di Messina

Lara Di Leonardo

PhD Student Biomedicine, Neuroscience and Advanced Diagnostics, Università di Palermo

Publications

Journal Paper
Tyndallized Bacteria Preferentially Induce Human Macrophage M1 Polarization: An Effect Useful to Balance Allergic Immune Responses and to Control Infections
Serena Di Vincenzo , Simona Taverna , Velia Malizia , Marco Buscetta, PhD , Chiara Cipollina, PhD , Valentina Lazzara , Paola Pinto , M Bassano , Stefania La Grutta , Elisabetta Pace
Antibiotics 2023, 12(3), 571.
https://doi.org/10.3390/antibiotics12030571
Journal Paper
Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide
Marta Cristaldi , Marco Buscetta, PhD , Maura Cimino , Agnese La Mensa , Maria Rita Giuffrè , Luigi Fiore , Claudia Carcione , Fabio Bucchieri , Francesca Rappa , Claudia Coronnello, PhD , Nicolina Sciaraffa, PhD , Santina Amato , Tommaso Silvano Aronica , Giovanna Lo Iacono , Alessandro Bertani , Elisabetta Pace , Chiara Cipollina, PhD ,
Cell Death Dis, 2023 Nov 25;14(11):773.
https://doi.org/10.1038/s41419-023-06318-6
Journal Paper
Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
Chiara Cipollina, PhD , Bruno Andreina , Fasola Salvatore , Marta Cristaldi , Patella Bernardo , Inguanta Rosalinda , Vilasi Antonio , Aiello Giuseppe , La Grutta Stefania , Torino Claudia , Pace Elisabetta
International Journal of Molecular Sciences
https://doi.org/10.3390/ijms23031770
Journal Paper
Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation
Chiara Cipollina, PhD , Di Vincenzo, Serena , Gerbino, Stefania , Siena, Liboria , Gjomarkaj, Mark , Pace, Elisabetta
Biochimica et Biophysica Acta - General Subjects
https://doi.org/10.1016/j.bbagen.2014.02.024
Journal Paper
Comparative cytoprotective effects of carbocysteine and fluticasone propionate in cigarette smoke extract-stimulated bronchial epithelial cells
Pace, Elisabetta , Ferraro, Maria , Di Vincenzo, Serena , Chiara Cipollina, PhD , Gerbino, Stefania , Cigna, Diego , Caputo, Valentina , Balsamo, Rossella , Lanata, Luigi , Gjomarkaj, Mark
Cell Stress and Chaperones
https://doi.org/10.1007/s12192-013-0424-0
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