Ministry of University and Research. Sicilian Micronanotech Research And Innovation Center – SAMOTHRACE (Innovation Ecosystem - cascade call - National Recovery and Resilience Plan (NRRP). Objective: development of a prototype of a smart device for respiratory disease self-testing. The proposed device will provide support for disease monitoring through the measurement of hydrogen peroxide concentration in easily accessible biological fluids (saliva and exhaled breath condensate), using a nanostructured biosensor previously developed by the partnership. The device will also include data processing systems, as well as Internet of Things (IoT) communication functions to allow real-time transmission of data to healthcare personnel to facilitate disease monitoring.

Ministry of University and Research. Innovation Ecosystem “THE – Tuscany Health Ecosystem“. National Recovery and Resilience Plan (NRRP). Cascade call managed by CNR-INO as Spoke 1.  Objective: synthesis and radiobiological validation of natural-based polymeric nanoparticles and theranostic nanogel (NG) radiolabelled with Lutetium-177 (a beta radioisotope, suitable for both diagnosis and therapy scopes) in prostate cancer cell lines. The expected result is the development of innovative NPP/NG from the synthetic and biocompatibility, cytotoxicity and internalization point of view, as well as from a functional point of view (diagnosis and therapy for prostate cancer).

Ministry of University and Research. Innovation Ecosystem “THE – Tuscany Health Ecosystem“. National Recovery and Resilience Plan (NRRP). Cascade call managed by Università degli Studi di Firenze as Spoke 2, 3, 5. Objective: the PRISMA Project aims at developing a telemedicine platform based on machine learning to improve the stratification of thromboembolic risk in patients with atrial fibrillation. The system will integrate synthetic models of the left atrial appendage, anatomical-physiological and fluid-dynamic parameters. It will employ neural networks to provide a personalised risk assessment, supporting the selection of the optimal therapeutic approach and promoting precision medicine.

Ministry of Enterprises and Made in Italy - Innovation Agreement. Objective: the NABUCCO project aims to develop innovative approaches for the diagnosis, risk stratification, and treatment of colorectal cancer, integrating advanced biotechnology, bioinformatics, and pharmaceutical development. The goal is to identify new therapeutic targets, optimize existing drugs, and develop predictive biomarkers of response and resistance to treatments, thus improving the efficacy of personalized therapies to increase patients' survival and quality of life.

Italian Ministry of Health. National Plan for complementary investments to the NRRP – “Innovative Health Ecosystem” Program – Investment E.3. Objective: establishing and consolidating a nationwide open and sustainable Technology Transfer Office (TTO) Network, to make available world-class services in a synergistic valuable way at national and international level in the health sector.

National Recovery and Resilience Plan (NRRP) – Mission 6 (Health), Component 2 – Investment 2.1. Enhancement and strengthening of NHS biomedical research. (Proof Of Concept). Objective: to assess the technical and commercial feasibility of an innovative cell-free nanomedicine strategy based on extracellular vesicles (EV), human induced pluripotent stem cells, and a young cell source.

Italian Ministry of Health - National Recovery and Resilience Plan (NRRP) - Mission 6 - Component 2 - Investment 2.1. Strengthening and enhancing biomedical research in the NHS_CALL 2023 Objective: to validate the druggability of PCYOX1 and identify potential hit compounds directed against it for the future development of cardiovascular and anticancer drugs.

Ministry of University and Research. D34Health – Digital Driven Diagnostics, prognostics, and therapeutics for sustainable Healthcare – National Plan for Complementary Investments to the NRRP. Cascade call managed by Spoke 4 – “Biological and bioengineered in vitro models for care through Digital Twin approaches”, Politecnico di Torino. Objective: enhance the current Genomics/Transcriptomics laboratory with the necessary equipment for extracting genetic material from a single cell and install a dedicated server for processing and storing acquired data. Standardized experimental protocols will be developed for the creation and sequencing of DNA or RNA libraries for bulk and/or single-cell analysis, as well as computational protocols for appropriate bioinformatics analyses.

Italian Ministry of Health - National Recovery and Resilience Plan (NRRP) - Mission 6 - Component 2 - Investment 2.1. Strengthening and enhancing biomedical research in the NHS_CALL 2023. Objective: validating a medical device that can address clinical deficiencies in a non-pathological model, allowing for the assessment of the local mechanical, immunological, and histological effects of the esophageal graft under study.

European Research Council (ERC) - Proof Of Concept (ERC-2023-POC) Objective: to develop better Mitral Valve repair techniques that are simple, effective, and durable, further advancing and validating BioChord, the first ever polymeric bioengineered regenerative Chordae Tendinae, designed to first repair the MV by replacing the diseased CT.