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Abstract
Air pollutants, including organic and inorganic molecules, have been associated with an increased risk of developing neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. Prolonged exposure to these pollutants can cause systemic inflammation and oxidative stress, which contribute to neuronal damage and the progression of these diseases.
Chemoinformatics offers powerful tools for research in this field, allowing to analyze and model large amounts of chemical and biological data. Through the use of molecular descriptors and fingerprints as input to machine learning algorithms and predictive models, the molecular informatics group is identifying novel correlations between pollutants and molecular mechanisms associated with neurodegenerative diseases, accelerating the discovery of potential biomarkers and therapeutic targets.
Pipeline
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CLINICAL
NEED -
DISEASES
ANALYSIS - DISCOVERY
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PRECLINICAL
VALIDATION -
PRECLINICAL
DEVELOPMENT -
CLINICAL
STUDIES
Principal Investigator
Contatto
Aree terapeutiche:
Prodotto:
Biomarcatori – Dispositivi biomedicali e Organi artificiali
Collaborazioni:
University College London (UCL), Londra, Regno Unito
Great Ormond Street Hospital (GOSH), Londra, Regno Unito
Università degli Studi di Palermo, Palermo, Italia
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