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Abstract

Air pollutants, including organic and inorganic molecules, have been associated with an increased risk of developing neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. Prolonged exposure to these pollutants can cause systemic inflammation and oxidative stress, which contribute to neuronal damage and the progression of these diseases.

Chemoinformatics offers powerful tools for research in this field, allowing to analyze and model large amounts of chemical and biological data. Through the use of molecular descriptors and fingerprints as input to machine learning algorithms and predictive models, the molecular informatics group is identifying novel correlations between pollutants and molecular mechanisms associated with neurodegenerative diseases, accelerating the discovery of potential biomarkers and therapeutic targets.

Pipeline

  • CLINICAL
    NEED
  • DISEASES
    ANALYSIS
  • DISCOVERY
  • PRECLINICAL
    VALIDATION
  • PRECLINICAL
    DEVELOPMENT
  • CLINICAL
    STUDIES

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Principal Investigator

Contatto

uperricone@fondazionerimed.com

Aree terapeutiche:

Prodotto:
Biomarcatori – Dispositivi biomedicali e Organi artificiali

 

Collaborazioni:
University College London (UCL), Londra, Regno Unito
Great Ormond Street Hospital (GOSH), Londra, Regno Unito
Università degli Studi di Palermo, Palermo, Italia

 

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